Pathogenesis of Bacterial Infections in Animals

, by Gyles, Carlton L.; Prescott, John F.; Songer, J. Glenn; Thoen, Charles O.

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ISBN: 9780813812373 | 0813812372
Cover: Hardcover
Copyright: 6/29/2010

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Pathogenesis of Bacterial Infections in Animals, Fourth Edition captures the rapid developments in understanding the mechanisms of virulence of the major bacterial pathogens of animals. Now including a color plate section, the book presents an overview of pathogenesis, including relevant events that occur in the herd or flock and its environment, and activities that take place at the cellular and molecular levels. With contributions from 64 experts in the field, this book serves as a great reference for graduate students in veterinary medicine and animal science, microbiologists, virologists and pathologists.

Preface
Contributors
Themes in Bacterial Pathogenic Mechanisms
Introduction
Basic Steps in Pathogenesis Continue to Provide a Sound Foundation
Concepts of Virulence are Being Refined
Host-Bacteria Communication is Critical
Pathogenesis in the Post-Genomic Era
Evolution of Pathogens-The Path Traveled May Provide Insights into the Road Ahead
Subversion of the Immune Response by Bacterial Pathogens
Introduction
Subversion of Innate Immune Responses
Subversion of Adaptive Immunity
Conclusion
Evolution of Bacterial Virulence
What are Pathogens and How do They Emerge?
Bacterial Fitness and Virulence
Sources of Genetic Diversity, Population Structure, and Genome Plasticity
Pathogenicity Islands
Bacteriophages and Their Role in Pathogen Evolution and Virulence
Illustrations of Virulence Evolution
Conclusion
Streptococcus
Introduction
Streptococcus agalactiae
Streptococcus dysgalactiae
Streptococcus uberis
Streptococcus equi
Streptococcus zooepidemicus
Streptococcus canis
Streptococcus porcinus
Streptococcus suis
Streptococcus pneumoniae
Gaps in Knowledge and Anticipated Developments
Staphylococcus
Introduction
Characteristics of the Organism
Pathogenic Staphylococcus Species
Sources of the Bacterium
Bacterial Virulence Factors
Pathogenesis
Types of Disease and Pathologic Changes
Interactions between the Bacterium and Host Defenses
Immunity and Its Impact on Pathogenesis
Conclusions: New Developments
Bacillus anthracis
Introduction
Etiology, Ecology, and Epidemiology
Symptomatology and Diagnosis
Bacteriology
Pathogenesis
Immunology
Control
Future Directions
Mycobacterium
Introduction
Characteristics and Sources of the Organisms
Bacterial Virulence Factors
Pathogenesis
Immunity
Gaps in Knowledge and Anticipated Developments
Corynebacterium and Arcanobacterium
Corynebacterium
Corynebacterium pseudotuberculosis
Other Corynebacteria
Arcanobacterium
Arcanobacterium pyogenes
Future Directions
Rhodococcus
Introduction
Characteristics and Sources of the Organism
Bacterial Virulence Factors
Pathogenesis
Gaps in Knowledge and Anticipated Developments
Listeria
Introduction
Characteristics
Sources of Infection
Virulence Factors
Pathogenesis
Host-Pathogen Interactions in Listeriosis
Prevention and Treatment
Conclusion
Neurotoxigenic Clostridia
Introduction
Clostridium tetani and Clostridium botulinum
Toxins
Tetanus
Botulism
Control and Prevention
BoNT as Therapeutics
Conclusions
Histotoxic Clostridia
Introduction
Virulence Factors and Pathogenesis
Clostridium perfringens
Clostridium septicum
Clostridium chauvoei
Clostridium novyi
Clostridium sordellii
Conclusion
Enteric Clostridia
Introduction
Clostridium perfringens
Clostridium difficile
Clostridium septicum
Clostridium spiroforme
Clostridium piliforme
Gaps in Knowledge and Anticipated Developments
Salmonella
Introduction
Salmonella Infections of Cattle
Salmonella Infections of Sheep
Salmonella Infections of Pigs
Infections of Domestic Fowl and Other Avian Species
Colonization of the Intestine
Salmonella Invasion and Enteropathogenesis
Systemic Disease
Genome Structure with Reference to Virulence
Immunity to Infection and Its Manipulation by Salmonella
Conclusion-Problems and Opportunities
Color Plate Section
Escherichia coli
Introduction
Types of Escherichia coli Implicated in Disease
ETEC
Pathogenesis of ETEC
STEC
EPEC
ExPEC
Immunity
Conclusions
Yersinia
Introduction
Classifi cation of Yersinia Species
Sources of Yersinia Species
Virulence Factors
Pathogenesis
Vaccines
Future Directions
Pasteurella
Introduction
Characteristics and Sources of the Organisms
Diseases Caused by Pasteurella multocida
Pasteurella multocida: Bacterial Virulence Factors
Pathogenesis
Immunity in Pasteurella multocida Infections
Gaps in Knowledge and Anticipated Developments
Acknowledgment
Mannheimia
Introduction
Characteristics and Sources of Mannheimia
Bacterial Virulence Factors
Pathogenesis and Disease
Gaps in Knowledge and Anticipated Developments
Acknowledgments
Actinobacillus
Actinobacillus pleuropneumoniae
Actinobacillus lignieresii
Actinobacillus equuli
Actinobacillus suis
Future Prospects
Haemophilus
Introduction
Characteristics
Habitat and Transmission
Histophilus somni
Haemophilus parasuis
Avibacterium paragallinarum
Conclusions
Bordetella
Introduction
Characteristics of the Genus
Sources of the Bacteria
Virulence Factors
Pathogenesis
Conclusion
Brucella
Introduction
Characteristics and Sources of the Organisms
Bacterial Virulence Factors
Pathogenesis
Disease Control and Epidemiology
Gaps in Knowledge and Anticipated Developments
Pseudomonas
Introduction
Overview of Pathogenesis
Virulence Factors of Pseudomonas aeruginosa
Antibiotic Resistance
Impact of Whole Genome Sequences
Vaccines
Conclusions and Future Prospects
Moraxella
Introduction
Infectious Bovine Keratoconjunctivitis
Pathogenesis of Moraxella bovis
Conclusions
Campylobacter and Helicobacter
Campylobacter
Helicobacter
Gastric Helicobacters
Enterohepatic Helicobacters
Pathogenesis and Virulence Factors
Conclusions
Lawsonia intracellularis
Characteristics of Lawsonia intracellularis
Sources of Lawsonia intracellularis
Virulence Factors
Pathogenesis
Conclusion
Gram-negative Anaerobes
Introduction
General Bacterial Virulence Factors
Fusobacterium
Bacteroides
Prevotella and Porphyromonas
Dichelobacter
Treponema
Brachyspira
Gaps in Knowledge and Anticipated Developments
Leptospira
Leptospira-The Basics
Leptospirosis-The Disease
Genomics, Proteomics, and Molecular Biology
Pathogenesis of Leptospirosis
Mechanisms of Immunity in Leptospirosis
Diagnosis of Leptospirosis and The Typing of Isolates
Gaps in Knowledge and Anticipated Developments
Acknowledgments
Mycoplasma
Introduction
Characteristics of the Organism
Sources of the Bacterium
Bacterial Virulence Factors
Pathogenesis
Interactions
Protective Immunity
Conclusions
Chlamydia
Introduction
Classifi cation
Host-Parasite Relationship: Clinical Disease and Pathogenesis
Life Cycle
Aberrant Development Cycle
Host Response
Prevention and Control
Future Directions
Rickettsiales
Introduction
Family Anaplasmataceae
Family Rickettsiaceae
Index
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Pathogenesis of Bacterial Infections in Animals

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Table of Contents

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