Pathway Analysis for Drug Discovery

This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.

ANTON YURYEV, PHD, is the Senior Director of Application Science at Ariadne Genomics Inc. His department studies the topological and evolutionary properties of biological networks and develops algorithms for pathway reconstruction and analysis of high-throughput data. Dr. Yuryev has published more than thirty scientific publications and is the author of several algorithms for primer design and pathway analysis.

Preface	p. vii
Contributors	p. ix
Introduction to Pathway Analysis	p. 1
Software Infrastructure and Data Model for Pathway Analysis	p. 27
Automatic Pathway Inference in Heterogeneous Biological Association Networks	p. 47
Algorithmic Basis for Pathway Visualization	p. 67
Pathway Analysis of High-Throughput Experimental Data	p. 103
Integrative Pathway Analysis of Disease Molecular Data	p. 121
Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways, Potential Targets, and Noise	p. 149
Mammalian Proteome and Toxicant Network Analysis	p. 165
Unraveling Mechanisms of Toxicity with the Power of Pathways: ToxWiz Tool as an Illustrative Example	p. 195
Impact of Chemistry Information on Pathway Analysis	p. 219
Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks	p. 237
An Adaptive System Model of the Yeast Glucose Sensor System	p. 263
Present and Future of Pathway Analysis in Drug Discovery	p. 285
Index	p. 297
Table of Contents provided by Ingram. All Rights Reserved.

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Pathway Analysis for Drug Discovery Computational Infrastructure and Applications

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