Pharmaceutical Isothermal Calorimetry

Pharmaceutical Isothermal Calorimetry discusses the application of isothermal calorimetric techniques to challenges encountered during the rational design and development of novel drugs and drug delivery systems. Providing a comprehensive review of recent research and trends, this book contains an expert discussion of research and applications to pharmaceutical characterization and formulation.

Simon Gaisford is Lecturer in Pharmaceutics at The School of Pharmacy, University of London, United Kingdom Michael A. A. O'Neill is a Teaching Fellow at the Department of Pharmacy and Pharmacology, University of Bath, United Kingdom

Dedication

iii

Preface

v

1. Principles of Calorimetry

1

(54)

Introduction

1

(3)

Brief History of Calorimetry

4

(2)

Heat as an Indicator of Change

6

(2)

Introduction to Thermodynamics

8

(5)

Classification of Calorimeters

13

(3)

Operating Principles

16

(17)

Instrumentation

33

(15)

Summary

48

(1)

Resources

49

(1)

References

50

(5)

2. Good Experimental Practice

55

(50)

Introduction

55

(1)

Good Experimental Practice

56

(3)

Calibration and Validation

59

(4)

Good Practice for Ampoule/Batch Calorimetry

63

(2)

Good Practice for Titration Calorimetry

65

(4)

Good Practice for Solution Calorimetry

69

(3)

Good Practice for Perfusion Calorimetry

72

(2)

Good Practice for Flow Calorimetry

74

(2)

Applications of Test and Reference Reactions

76

(9)

Experimental Design

85

(3)

Special Considerations for Flow Calorimeters

88

(12)

Summary

100

(1)

References

101

(4)

3. Quantitative Data Analysis

105

(72)

Introduction

105

(1)

Empirical Fitting

106

(1)

Kinetic Modeling

107

(43)

Calculation vs. Iteration

150

(1)

Calculation Techniques

151

(12)

Solid-State Systems

163

(4)

Complex Reaction Systems

167

(7)

Summary

174

(1)

References

174

(3)

4. Role of Calorimetry in Preformulation Studies

177

(40)

Introduction

177

(1)

Use of Differential Scanning Calorimetry in Preformulation

178

(16)

Use of Isothermal Calorimetry in Preformulation

194

(15)

Summary

209

(1)

References

210

(7)

5. Lead Compound Optimization

217

(32)

Introduction

217

(1)

Application of Isothermal Titration Calorimetry to Rational Drug Design

218

(13)

Lead Optimization Using Isothermal Flow Calorimetry

231

(13)

Summary

244

(1)

References

245

(4)

6. Investigation of the Amorphous State

249

(40)

Introduction

249

(1)

Amorphous Material

250

(5)

Aging of Amorphous Material

255

(4)

Quantification of Amorphous Content

259

(25)

Summary

284

(1)

References

285

(4)

7. Stability Assessment

289

(46)

Introduction

289

(1)

Current Methods for Stability Assessment

290

(5)

Calorimetry for Stability Assessment

295

(34)

Summary

329

(1)

References

329

(6)

8. Future Developments and Areas of Application

335

(18)

Introduction

335

(1)

Whole System Measurements

335

(11)

Applications to Process Scale-Up and Process

Analytical Technology

346

(2)

High-Throughput Screening Methodologies

348

(2)

Summary

350

(1)

References

351

(2)

Index

353

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Pharmaceutical Isothermal Calorimetry

Summary

Author Biography

Table of Contents

Supplemental Materials

FREE SHIPPING

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5% off 1 book, 7% off 2 books, 10% off 3+ books

Pharmaceutical Isothermal Calorimetry

Summary

Author Biography

Table of Contents

Supplemental Materials

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