Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine

Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine provides a primer to understand the interface between pharmacogenetics (the study of genetic factors that influence how a drug works) and pharmacokinetics (how the body handles a drug) and pharmacodynamics (and the affect(s) of a drug on the body ) and how this can allow for optimal individual patient care, that is, "personalized medicine." Reviewing these parameters, students will learn how the genetic constitution of an individual may lead to the need for an altered dose or in some cases alternative drug therapy. This contemporary text presents a number of drugs, describing specific relationships between genetics and drug action and how the body handles the particular drug as well as specific case examples of genetics related to adverse drug reactions, altered metabolism, and drug efficacy. This text also addresses issues, including ethics related to pharmacogenomics, and study designs, among other topics.

SectionI
Chapter1 Introduction to Personalized Medicine
SectionII
Chapter2 Pharmacogenetics and Pharmacokinetics
Chapter3 Pharmacogenetics and Pharmacodynamics
SectionIII
Chapter4 Abacavir
Chapter5 Carbamazepine
Chapter6 Clopidogrel
Chapter7 5-Fluorouracil
Chapter8 Irinotecan
Chapter9 6-Mercaptopurine
Chapter10 Warfarin
SectionIV
Chapter11 The Breadth of Personalized Medicine