Pharmacokinetic Principles of Dosing Adjustments: Understanding the Basics

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ISBN: 9781566768993 | 1566768993
Cover: Nonspecific Binding
Copyright: 11/30/2000

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Provides the concepts used to formulate approaches but is not intended to be a clinical guide to dosing adjustments. For students and practitioners who practice in a setting that requires careful consideration to dosing parameters and with patients requiring constant monitoring of therapeutic outcomes, including dosing adjustments. Softcover.

Preface	p. xi
Basic Concepts
Pharmacokinetic Processes	p. 3
Introduction	p. 3
Overview of Pharmacokinetic Processes	p. 3
Study Guide for Chapter 1	p. 14
Kinetic Processes Applied to the Whole Body	p. 17
Introduction	p. 17
Classical Pharmacokinetic Models	p. 21
Justification for Application of a One-Compartment Model	p. 25
Study Guide for Chapter 2	p. 27
Disposition Parameters of the One-Compartment Model	p. 29
Introduction	p. 29
Elimination Rate Constant	p. 30
Half-Life	p. 34
Volume of Distribution	p. 36
Area Under the Plasma Concentration-Time Curve	p. 41
Systemic Clearance	p. 44
Study Guide for Chapter 3	p. 46
Parameters Used in Adjusting Doses	p. 49
Therapeutic Drug Monitoring and the Retrospective Approach	p. 49
Prospective Approach	p. 51
Urine Measurements of Drugs and Renal Clearance	p. 56
Dosage Adjustment in Renal Failure	p. 60
Hepatic Elimination and Dosing Adjustments	p. 67
Study Guide for Chapter 4	p. 68
Parenteral Dosing Adjustments
Infusion	p. 73
Introduction	p. 73
Basic Infusion Principles	p. 74
Bolus Dose Plus Constant Rate Infusion	p. 79
Rapid Infusion Followed by Slow Infusion	p. 82
Intermittent Infusion	p. 84
Study Guide for Chapter 5	p. 90
Oral Dosing
Important Parameters	p. 95
Introduction	p. 95
Fraction Absorbed (F)	p. 98
Absorption Rate Constant	p. 100
Factors Affecting the Absorption of Drugs	p. 103
Study Guide for Chapter 6	p. 120
Bioavailability/Bioequivalence	p. 123
Introduction	p. 123
Definitions	p. 124
Bioavailability Measurements	p. 125
Bioequivalence	p. 127
Generic Substitution	p. 131
Study Guide for Chapter 7	p. 134
Multiple Dosing Regimens	p. 137
Introduction	p. 137
Superposition Principle and Multiple Dosing	p. 138
Multiple Dosing Factor	p. 138
Multiple Dosing Equations	p. 143
Accumulation	p. 145
Missed Dose	p. 154
Study Guide for Chapter 8	p. 157
Advanced Considerations
Two-Compartment Model	p. 163
Introduction	p. 163
Volumes of Distribution	p. 171
IV Infusion: Two-Compartment Model	p. 175
Dosing Strategies	p. 180
Advanced Considerations	p. 187
Study Guide for Chapter 9	p. 191
An Introduction to Nonlinear Pharmacokinetics	p. 193
Introduction	p. 193
Application to Phenytoin Dosing Regimens	p. 197
Single-Point Method	p. 201
Bayesian Approach	p. 203
Study Guide for Chapter 10	p. 205
Study Guide Solutions	p. 207
Index	p. 255
Table of Contents provided by Syndetics. All Rights Reserved.

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