Phototherapy and Photochemotherapy for Skin Disease, Third Edition

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ISBN: 9781574448801 | 1574448803
Cover: Hardcover
Copyright: 7/18/2005

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Johns Hopkins Univ., Baltimore, MD. Text provides data on ultraviolet (UV) therapy and discusses UV treatments in terms of their biological effects. Offers methods for patient selection and considers the use of PUVA therapy to treat pigmented purpuras and psoriasis. For practitioners. Previous edition: c1991.

Series Introduction

Preface

vii

Acknowledgment

Part 1: Basic Principles of Photobiology

(44)

1. Electromagnetic Radiation

(10)

Introduction

(1)

Wavebands

(2)

Energy of Photons

(2)

Units of Measurement

(1)

Interactions of Photons and Matter

(6)

2. Sources of Nonionizing Radiation

(8)

Introduction

(2)

The Sun

(1)

Fluorescent Lamps

(2)

High-Pressure Mercury Vapor Lamp

(1)

Metal Halide Lamps

(1)

Wood's Lamp

(1)

Optical Filters

(2)

3. Nonionizing Radiation and the Skin

(12)

Skin Optics

(4)

Morphologic Responses to Radiation

(5)

Definitions

(3)

4. Nonionizing Radiation and Other Organs

(6)

Introduction

(1)

The Eye

(3)

The Immune System

(1)

The Neuroendocrine System

(2)

5. Phototesting

(6)

Introduction

(1)

Indications for Phototesting

(1)

Equipment

(1)

Methods

(3)

Part 2: Management of Psoriasis Vulgaris

(116)

6. Evaluation of the Patient

(6)

Introduction

(1)

The Patient

(1)

The Disease

(2)

Previous Treatment for Psoriasis

(1)

Past and Concurrent Conditions

(1)

Social and Economic Factors

(1)

Physical Examination

(1)

Laboratory Investigations

(1)

Ophthalmologic Examination

(1)

Bibliography

(1)

7. The Therapies Available

(6)

Introduction

(1)

Topical Agents

(1)

UV Radiation

(1)

Systemic Therapy

(1)

Other Aspects of Treatment

(2)

Bibliography

(1)

8. Which Therapy to Use?

(6)

Introduction

(1)

Indications for UV Therapy

(1)

Contraindications to UV Therapy

(1)

PUVA Therapy or UVB Phototherapy?

(4)

9. Oral PUVA Therapy

(46)

Introduction

(1)

Psoralens

(3)

UVA Radiation

(3)

Cutaneous Responses

(2)

Cellular Responses

(1)

Treatment Schedules

(7)

Response to PUVA Therapy

(2)

Maintenance Therapy

(2)

Precautions

(2)

Education of Patients

(1)

Short-Term Side Effects

(7)

Long-Term Side Effects

(3)

Guidelines for use of PUVA Therapy

(1)

Other Forms of Oral PUVA Therapy

(2)

Bibliography

101

(10)

10. Topical PUVA Therapy

111

(12)

Introduction

111

(1)

Pharmacology

111

(2)

Photobiology

113

(1)

Patient Selection

113

(1)

Treatment Schedules

113

(2)

Precautions

115

(1)

Side Effects

116

(1)

Advantages/Disadvantages of Topical PUVA Therapy

116

(2)

Other Forms of Topical Therapy

118

(1)

Bibliography

118

(5)

11. UVB Phototherapy

123

(16)

Introduction

123

(1)

The Treatments

123

(5)

Adjunctive Treatment

128

(1)

Response to Therapy

128

(1)

Maintenance Therapy

129

(1)

Precautions

130

(1)

Adverse Effects

130

(5)

Bibliography

135

(4)

12. Other Forms of Phototherapy

139

(10)

Introduction

139

(1)

Goeckerman Regimen

139

(3)

Tar Photosensitization

142

(1)

Home Phototherapy

143

(1)

Climatotherapy

144

(2)

Tanning Parlor Phototherapy

146

(1)

Bibliography

147

(2)

13. Combination Therapy

149

(12)

Introduction

149

(1)

PUVA/Broadband UVB Therapy

150

(2)

Acitretin

152

(1)

Methotrexate

153

(1)

Cyclosporin

154

(1)

Topical Agents

154

(1)

Biologic Therapies

155

(1)

Why is Combination Therapy not Routine?

155

(1)

Bibliography

155

(6)

Part 3: Treatment of Other Diseases

161

(78)

14. Psoriasis Variants

163

(10)

Introduction

163

(1)

Generalized Pustular Psoriasis

163

(2)

Erythrodermic Psoriasis

165

(1)

Guttate Psoriasis

166

(2)

Psoriasis of the Palms and Soles

168

(2)

Psoriasis of the Nails

170

(1)

Bibliography

170

(3)

15. Eczema

173

(12)

Introduction

173

(1)

Indications for Therapy

173

(1)

Atopic Eczema

174

(2)

Hand Eczema

176

(1)

Other Eczemas

177

(2)

Adjunctive Treatment

179

(1)

Combination Therapy

179

(1)

Problems of Therapy

180

(2)

Bibliography

182

(3)

16. Mycosis Fungoides

185

(10)

Introduction

185

(1)

Indications for UV Therapy

185

(1)

Diagnosis, Evaluation, and Staging of Disease

186

(1)

PUVA Therapy

186

(2)

Narrowband UVB Phototherapy

188

(1)

Broadband UVB Phototherapy

188

(1)

Combination Therapy

189

(1)

Photosensitivity

190

(1)

Bibliography

191

(4)

17. Vitiligo

195

(10)

Introduction

195

(1)

Treatment Options

196

(2)

Selection of Patients for UV Therapy

198

(1)

Investigations

199

(1)

UV Therapy

200

(2)

Other Disorders of Pigmentation

202

(1)

Bibliography

203

(2)

18. Photodermatoses

205

(10)

Introduction

205

(1)

Polymorphous Light Eruption

206

(2)

Solar Urticaria

208

(1)

Chronic Photosensitive Eczema

209

(2)

Erythropoietic Protoporphyria

211

(1)

Bibliography

211

(4)

19. Miscellaneous Diseases

215

(24)

Introduction

215

(1)

Alopecia Areata

215

(2)

Amyloidosis

217

(1)

Darier's Disease

218

(1)

Dermatitis Herpetiformis

218

(1)

Eosinophilic Cellulitis (Wells' Syndrome)

218

(1)

Eosinophilic Fasciitis

218

(1)

Eosinophilic Pustular Folliculitis

218

(1)

Erythema Multiforme

219

(1)

Erythrokeratoderma: Symmetrical and Progressive

219

(1)

Flegel's Disease

219

(1)

Graft-Versus-Host Disease

219

(1)

Granuloma Annulare

220

(1)

Granuloma Faciale

220

(1)

Histiocytosis X

220

(1)

Hypereosinophilic Syndrome

220

(1)

Ichtyosis Linearis Circumflexa

220

(1)

Keratosis Lichenoides Chronica

221

(1)

Lichen Planus

221

(1)

Lymphomatoid Papulosis

221

(1)

Mastocytosis

221

(1)

Necrobiosis Lipoidica Diabeticorum

221

(1)

Papuloerythroderma

222

(1)

Perforating Dermatosis

222

(1)

Pigmented Purpuric Dermatoses

222

(1)

Pityriasis Lichenoides

222

(1)

Pityriasis Rosea

223

(1)

Pityriasis Rubra Pilaris

223

(1)

Pruritus

223

(1)

Sclerosing Skin Diseases

224

(2)

Subacute Prurigo

226

(1)

Subcorneal Pustular Dermatosis

226

(1)

Transient Acantholytic Dermatosis

226

(1)

Urticaria

226

(1)

Vasculitis

227

(1)

Bibliography

228

(11)

Part 4: Special Situations

239

(22)

20. Problem Cases

241

(16)

Introduction

241

(1)

The Nonresponder

241

(6)

Development of a new Rash

247

(2)

Photosensitive Psoriasis

249

(1)

Unusual Erythemal Responses

250

(1)

Alterations in Pigmentation

251

(1)

HIV Infection

252

(1)

Bibliography

253

(4)

21. Treatment of Children

257

(4)

Introduction

257

(1)

Selection of Patients

257

(1)

Introduction to the Treatment

258

(1)

Choice of Treatment

258

(1)

Mechanics of the Treatment

259

(1)

Conclusions

260

(1)

Bibliography

260

(1)

Part 5: New Therapies

261

(22)

22. Targeted Phototherapy with Lasers and Other High-Intensity Sources

263

(8)

Introduction

263

(1)

The Excimer Laser

264

(2)

Other High-Intensity Sources

266

(2)

Bibliography

268

(3)

23. UVA-1 Phototherapy

271

(8)

Introduction

271

(1)

Indications

272

(1)

Adverse Effects

273

(1)

Mechanism of Action

274

(1)

Equipment

274

(1)

Conclusions

275

(1)

Bibliography

275

(4)

24. Phototherapy of Acne Vulgaris

279

(4)

Introduction

279

(1)

Treatments

280

(1)

Conclusions

281

(1)

Bibliography

281

(2)

Part 6: Practicing Photomedicine

283

(36)

25. Creating a Facility

285

(18)

Introduction

285

(1)

Space

285

(1)

Equipment

286

(15)

Bibliography

301

(2)

26. Operating a Facility

303

(16)

Introduction

303

(1)

Physician Training

303

(1)

Staff

304

(1)

Scheduling of Patients

305

(1)

Records

305

(4)

Supplies

309

(2)

Newsletter

311

(1)

Support Groups

312

(1)

Economic Considerations

312

(5)

Regulations

317

(2)

Index

319

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Phototherapy and Photochemotherapy for Skin Disease, Third Edition

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