Polymeric Drugs and Drug Delivery Systems

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ISBN: 9781566769563 | 1566769566
Cover: Hardcover
Copyright: 12/31/2000

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Polymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume consists of twenty-two recent research-based reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports were prepared by top scientists in the field and are based on current research conducted at leading laboratories in the U.S.A., Europe, and Asia.These 22 chapters report the latest information in the application of polymers to biological systems.

Preface

xiii

Semitelechelic Poly[N-(2-Hydroxypropyl)-Methacrylamide) For Biomedical Applications

(14)

Zheng-Rong Lu

Pavla Kopeckova

Jindrich Kopecek

Introduction

(1)

Synthesis of Semitelechelic HPMA Polymers

(4)

Characterization of Semitelechelic HPMA Polymers

(2)

Modification of Proteins with Semitelechelic HPMA Polymers

(3)

Modification of Biomedical Surfaces with Semitelechelic HPMA Polymers

(1)

Conjugation with Hydrophobic Anticancer Drugs

(1)

Conclusions

(1)

References

(2)

Thermoresponsive Polymeric Micelles for Double Targeted Drug Delivery

(24)

J. E. Chung

Teruo Okano

Introduction

(5)

Preparation of Thermoresponsive Polymeric Micelles (Scheme 3)

(10)

On--Off Switchable Drug Release from Thermoresponsive Polymeric Micelles

(2)

Cytotoxicity of Polymeric Micelles Modulated by Temperature Changes

(4)

References

(3)

pH/Temperature-Sensitive Polymers for Controlled Drug Delivery

(18)

Soon Hong Yuk

Sun Hang Cho

Sang Hoon Lee

Jung Ki Seo

Jin Ho Lee

Introduction

(1)

Experimental Section

(3)

Results and Discussion

(10)

Conclusions

(1)

References

(3)

Design of Polymeric Systems for Targeted Administration of Peptide and Protein Drugs

(12)

Emo Chiellini

Elisabetta E. Chiellini

Federica Chiellini

Roberto Solaro

Introduction

(1)

Experimental

(2)

Results and Discussion

(6)

Conclusions

(1)

References

(3)

Drug Release from Ionic Drugs from Water-Insoluble Drug-Polyion Complex Tablets

(18)

Nandini Konar

Cherng-Ju Kim

Introduction

(1)

Experimental

(2)

Results and Discussion

(11)

Conclusions

(1)

References

(3)

Polychelating Amphiphilic Polymers (PAP) As Key Components of Microparticulate Diagnostic Agents

(14)

Vladimir P. Torchilin

Imaging Principles and Modalities

(2)

Loading of Liposomes and Micelles with Contrast Agents

(1)

Diagnostic Liposomes and Micelles with PAPs

(6)

Experimental Visualization with PAP-Containing Microparticular Contrast Agents

(4)

References

(2)

Bioconjugation of Biodegradable Poly (Lactic/Glycolic Acid) To Protein, Peptide, and Anti-Cancer Drug: An Alternative Pathway for Achieving Controlled Release from Micro- and Nanoparticles

101

(14)

Tae Gwan Park

Introduction

101

(1)

Controlled Release from PLGA Microspheres

102

(1)

Conjugation of PLGA to Drugs

103

(1)

Conjugation of PLGA to Lysozyme

104

(2)

Conjugation of PLGA to an Amino Acid Derivative

106

(3)

Conjugation of PLGA to Doxorubicin

109

(4)

Conclusions

113

(1)

References

113

(2)

Elastin-Mimetic Protein Networks Derived from Chemically Crosslinked Synthetic Polypeptides

115

(16)

R. Andrew McMillan

Vincent P. Conticello

Introduction

115

(2)

Results and Discussion

117

(8)

Conclusions

125

(3)

References

128

(3)

Genetically Engineered Protein Domains as Hydrogel Crosslinks

131

(14)

Chun Wang

Russell J. Stewart

Jindrich Kopecek

Introduction

131

(1)

Hydrogels as Biomaterials

132

(1)

Genetically Engineered Biomaterials

132

(1)

Coiled Coils

133

(1)

Designs of Hybrid Hydrogels

134

(6)

Conclusions and Future Perspectives

140

(2)

References

142

(3)

Superporous Hydrogel Composites: A New Generation of Hydrogels with Fast Swelling Kinetics, High Swelling Ratio and High Mechanical Strength

145

(12)

Kinam Park

Jun Chen

Haesun Park

Introduction

145

(1)

Swelling Kinetics of Hydrogels

146

(1)

Hydrogels, Microporous Hydrogels, and Macroporous Hydrogels

147

(2)

Superporous Hydrogels (SPHs)

149

(1)

Methods of Preparing Porous Hydrogels

150

(2)

Superporous Hydrogel Composites (SPHs)

152

(1)

Applications

153

(1)

Future of SPHs and SPH Composites

154

(1)

References

155

(2)

Structure and Solute Size Exclusion of Poly(Methacrylic Acid)/Poly(N-Isopropyl Acrylamide) Interpenetrating Polymeric Networks

157

(12)

Jing Zhang

Nicholas A. Peppas

Introduction

157

(1)

Experimental

158

(2)

Results and Discussion

160

(7)

Conclusion

167

(1)

References

167

(2)

Thermodynamics of Water Sorption in Hyaluronic Acid and Its Derivatives

169

(12)

P. A. Netti

L. Ambrosio

L. Nicolais

Introduction

169

(1)

Materials

170

(2)

Results

172

(6)

Discussion

178

(1)

Conclusions

179

(1)

References

180

(1)

Photocrosslinked Polyanhydrides with Controlled Hydrolytic Degradation

181

(16)

Amy K. Burkoth

Kristi S. Anseth

Introduction

181

(2)

Experimental

183

(2)

Results

185

(8)

Conclusions

193

(1)

References

194

(3)

Novel Cytokine-Inducing Macromolecular Glycolipids From Gram-Positive Bacteria

197

(14)

Masahito Hashimoto

Yasuo Suda

Yoshimasa Imamura

Jun-Ichi Yasuoka

Kazue Aoyama

Toshihide Tamura

Shozo Kotani

Shoichi Kusumoto

Introduction

197

(1)

Material and Methods

198

(2)

Results and Discussion

200

(9)

References

209

(2)

Hydrophobe Modified Cationic Polysaccharides for Topical Microbicide Delivery

211

(20)

George L. Brode

Gustavo F. Doncel

John E. Kemnitzer

Introduction

211

(2)

Rationale for Design

213

(3)

Chemistry of Vehicles

216

(2)

DCE Vehicle Characterization

218

(2)

Anti-Viral Design Parameters

220

(2)

Contraceptive Design Parameters

222

(2)

Vehicle Bioadhesion

224

(1)

Summary

225

(1)

Future Considerations

225

(2)

References

227

(4)

Novel Antimicrobial N-Halamine Polymer Coatings

231

(8)

S. D. Worley

M. Eknoian

J. Bickert

J. F. Williams

Introduction

231

(2)

Experimental

233

(2)

Results and Discussion

235

(3)

Conclusion

238

(1)

References

238

(1)

Design of Macromolecular Prodrug of Cisplatin Attached to Dextran Through Coordinate Bond

239

(12)

Tatsuro Ouchi

Mitsuo Matsumoto

Tatsunori Masunaga

Yichi Ohya

Katsurou Ichinose

Mikirou Nakashima

Masataka Ichikawa

Takashi Kanematsu

Introduction

239

(1)

Experimental

240

(4)

Results and Discussion

244

(6)

References

250

(1)

Synthesis of Linear and Hyperbranched Stereoregular Aminopolysaccharides by Oxazoline Glycosylation

251

(14)

Jun-Ichi Kadokawa

Hideyuki Tagaya

Koji Chiba

Introduction

251

(2)

Experimental

253

(1)

Results and Discussion

254

(8)

Conclusions

262

(1)

References

263

(2)

Diameter and Diameter Distributions of Poly(l-Lactide) Microspheres by Ring-Opening Polymerization of l-Lactide and From Earlier Synthesized Polymers

265

(14)

Stanley Slomkowski

Stanley Sosnowski

Introduction

265

(1)

Experimental Part

266

(2)

Results and Discussion

268

(9)

Conclusions

277

(1)

References

277

(2)

Examination of Fluorescent Molecules as in Situ Probes of Polymerization Reactions

279

(10)

Francis W. Wang

Deborah G. Sauder

Introduction

279

(1)

Experimental

280

(1)

Results

281

(6)

Conclusions

287

(1)

References

287

(2)

Self-Etching, Polymerization-Initiating Primers for Dental Adhesion

289

(12)

Chetan A. Khatri

Joseph M. Antonucci

Gary E. Schumacher

Introduction

289

(3)

Experimental

292

(3)

Results and Discussion

295

(5)

References

300

(1)

Bioactive Polymeric Composites Based on Hybrid Amorphous Calcium Phosphates

301

(10)

Joseph M. Antonucci

Drago Skrtic

Arthur W. Hailer

Edward D. Eanes

Introduction

301

(1)

Experimental

302

(4)

Results and Discussion

306

(4)

Conclusion

310

(1)

References

310

(1)

Index

311

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Polymeric Drugs and Drug Delivery Systems

Summary

Table of Contents

Supplemental Materials