Population Genetics: A Concise Guide

This concise introduction offers students and researchers an overview of the discipline that connects genetics and evolution. Addressing the theories behind population genetics and relevant empirical evidence, John Gillespie discusses genetic drift, natural selection, nonrandom mating, quantitative genetics, and the evolutionary advantage of sex. First published to wide acclaim in 1998, this brilliant primer has been updated to include new sections on molecular evolution, genetic drift, genetic load, the stationary distribution, and two-locus dynamics. This book is indispensable for students working in a laboratory setting or studying free-ranging populations.

John H. Gillespie is a professor of evolution at the University of California, Davis.

List of Figures

ix

Preface

xi

1 Genetic Variation

1

(20)

1.1 DNA variation in Drosophila

2

(4)

1.2 Loci and alleles

6

(4)

1.3 Genotype and allele frequencies

10

(2)

1.4 The Hardy-Weinberg law

12

(6)

1.5 Answers to problems

18

(3)

2 Genetic Drift

21

(38)

2.1 A first look at genetic drift

22

(3)

2.2 The decay of heterozygosity

25

(4)

2.3 Mutation and drift

29

(3)

2.4 Molecular evolution

32

(4)

2.5 The neutral theory

36

(4)

2.6 The coalescent

40

(7)

2.7 The effective size of a population

47

(2)

2.8 Another model of genetic drift

49

(4)

2.9 The stationary distribution

53

(2)

2.10 Is genetic drift important in evolution?

55

(1)

2.11 Answers to problems

56

(3)

3 Natural Selection

59

(42)

3.1 The fundamental model

61

(1)

3.2 Relative fitness

62

(2)

3.3 Three kinds of selection

64

(6)

3.4 Mutation-selection balance

70

(1)

3.5 Genetic load

71

(5)

3.6 The heterozygous effects of alleles

76

(9)

3.7 Changing environments

85

(5)

3.8 The stationary distribution

90

(1)

3.9 Selection and drift

91

(4)

3.10 Molecular evolution

95

(3)

3.11 Answers to problems

98

(3)

4 Two-Locus Dynamics

101

(18)

4.1 Linkage disequilibrium

101

(4)

4.2 Two-locus selection

105

(6)

4.3 Genetic draft

111

(5)

4.4 Answers to problems

116

(3)

5 Nonrandom Mating

119

(20)

5.1 Generalized Hardy-Weinberg

120

(1)

5.2 Identity by descent

121

(2)

5.3 Inbreeding

123

(4)

5.4 The evolution of selfing

127

(4)

5.5 Subdivision

131

(5)

5.6 Answers to problems

136

(3)

6 Quantitative Genetics

139

(30)

6.1 Correlation between relatives

139

(11)

6.2 Response to selection

150

(4)

6.3 Evolutionary quantitative genetics

154

(6)

6.4 Dominance

160

(6)

6.5 The intensity of selection

166

(2)

6.6 Answers to problems

168

(1)

7 The Evolutionary Advantage of Sex

169

(16)

7.1 Genetic segregation

170

(3)

7.2 Crossing-over

173

(1)

7.3 Muller's ratchet

174

(5)

7.4 Kondrashov's hatchet

179

(4)

7.5 Answers to problems

183

(2)

Appendix A Mathematical Necessities

185

(4)

Appendix B Probability

189

(18)

Bibliography

207

(4)

Index

211

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Population Genetics: A Concise Guide

Summary

Author Biography

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Population Genetics: A Concise Guide

Summary

Author Biography

Table of Contents

Supplemental Materials

Digital License