Practical Microwave Synthesis for Organic Chemists Strategies, Instruments, and Protocols

With the novice user in mind, this beginner's guide explains the basics behind microwave technology, evaluates available instruments and reaction modes, and provides practical hints for every eventuality. Includes 27 detailed protocols for often-used reactions. From the contents: 1 Microwave Synthesis ? An Introduction 2 Microwave Theory 3 Equipment Review 4 Microwave Processing Techniques 5 Starting With Microwave Chemistry 6 Experimental Protocols 6.1 General Small-Scale Sealed-Vessel Microwave Processing 6.2 Reaction Optimization 6.3 Library Generation 6.4 Reaction Scale-Up 6.5 Special Processing Techniques

C. Oliver Kappe is Professor of Organic Chemistry and director of the Doppler Laboratory for Microwave Chemistry at the University of Graz, Austria. He holds a doctoral degree in organic chemistry from the University of Graz, where he became part of the faculty after periods of postdoctoral research work with Curt Wentrup at the University of Queensland (Australia), and with Albert Padwa at Emory University, Atlanta (USA).

Doris Dallinger studied chemistry at the University of Graz, Austria and in 2005 obtained a Ph.D. degree in the group of C. Oliver Kappe in microwave chemistry and high-throughput synthesis. She is currently investigating specific microwave effects and scale-up of microwave-assisted reactions.

Shaun Murphree is Professor of Chemistry at Allegheny College in Meadville (USA). He received his doctorate in organic chemistry at Emory University in Atlanta with Albert Padwa, followed by post-doctoral study in the laboratory of Peter Jacobi at Wesleyan University. After seven years in research and development at Bayer Corporation, he returned to academia in 1999, becoming a faculty member at Allegheny College.

1 Microwave Synthesis ? An Introduction 1 2 Microwave Theory 11 3 Equipment Review 45 4 Microwave Processing Techniques 87 5 Starting With Microwave Chemistry 163 6 Experimental Protocols 205 6.1 General Small-Scale Sealed-Vessel Microwave Processing 207 6.2 Reaction Optimization 234 6.3 Library Generation 239 6.4 Reaction Scale-Up 251 6.5 Special Processing Techniques