Practical Transfusion Medicine

• A succinct and user-friendly resource of transfusion medicine for clinicians, scientists and trainees with key points, charts and algorithms
• Discusses practice in blood centres and hospitals including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context
• Coverage of cellular and tissue therapies and organ transplantation including stem cell collection and haematopoietic stem cell processing and storage
• Review of the development of the evidence-base for transfusion medicine
• Content on the clinical practice for transfusion and alternatives to transfusion

MICHAEL F. MURPHY, Professor of Blood Transfusion Medicine, University of Oxford, UK

DAVID J. ROBERTS, Professor of Haematology, University of Oxford, UK

MARK H. YAZER, Professor of Pathology, University of Pittsburgh, USA; Adjunct Professor of Clinical Immunology, University of Southern Denmark, Denmark

List of Contributors ix

Preface xv

1 Introduction: Two Centuries of Progress in Transfusion Medicine 1
Walter H. (Sunny) Dzik and Michael F. Murphy

Part I Basic Principles of Immunohaematology 11

2 Essential Immunology for Transfusion Medicine 11
Jaap Jan Zwaginga and S. Marieke van Ham

3 Human Blood Group Systems 20
Geoff Daniels

4 Human Leucocyte Antigens 29
Cristina V. Navarrete and Colin J. Brown

5 Platelet and Neutrophil Antigens 43
Brian R. Curtis

6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion 58
Mark H. Yazer and Meghan Delaney

Part II Complications of Transfusions 69

7 Investigation of Acute Transfusion Reactions 69
Kathryn E. Webert and Nancy M. Heddle

8 Haemolytic Transfusion Reactions 81
Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman

9 Febrile and Allergic Transfusion Reactions 97
Mark K. Fung and Nancy M. Heddle

10 Lung Injury and Pulmonary Oedema After Transfusion 108
Steven H. Kleinman and Daryl J. Kor

11 Purported Adverse Effects of ‘Old Blood’ 118
Lirong Qu and Darrell J. Triulzi

12 Transfusion�]Induced Immunomodulation 125
Amy E. Schmidt, Majed A. Refaai, Joanna M. Heal and Neil Blumberg

13 Transfusion�]Associated Graft�]Versus�]Host Disease and Microchimerism 136
Beth H. Shaz, Richard O. Francis and Christopher D. Hillyer

14 Posttransfusion Purpura 147
Michael F. Murphy

15 Transfusion�]Transmitted Infections 153
Roger Y. Dodd and Susan L. Stramer

16 Bacterial Contamination 168
Sandra Ramírez�]Arcos and Mindy Goldman

17 Emerging Infections and Transfusion Safety 176
Roger Y. Dodd

Part III Practice in Blood Centres and Hospitals 184

18 Regulatory Aspects of Blood Transfusion 184
William G. Murphy, Louis M. Katz and Peter Flanagan

19 The Role of Haemovigilance in Transfusion Safety 193
Katharine A. Downes and Barbee I. Whitaker

20 Donors and Blood Collection 203
Marc Germain, Ellen McSweeney and William G. Murphy

21 Blood Donation Testing and the Safety of the Blood Supply 215
Mindy Goldman

22 Production and Storage of Blood Components 222
Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo

23 Blood Transfusion in Hospitals 233
Erica M. Wood, Mark H. Yazer and Michael F. Murphy

24 Blood Transfusion in a Global Context 254
David J. Roberts, Alan D. Kitchen, Stephen P. Field, Imelda Bates, Jean Pierre Allain and Meghan Delaney

Part IV Clinical Transfusion Practice 264

25 Inherited and Acquired Coagulation Disorders 264
Irina Chibisov and Franklin Bontempo

26 Massive Blood Loss 279
John R. Hess

27 Blood Management in Acute Haemorrhage and Critical Care 287
Gavin J. Murphy, Nicola Curry, Nishith N. Patel and Timothy S. Walsh

28 Point�]of�]Care Testing in Transfusion Medicine 302
Matthew D. Neal and Louis H. Alarcon

29 Haematological Disease 312
Lise J. Estcourt, Simon J. Stanworth and Michael F. Murphy

30 Blood Transfusion in the Management of Patients with Haemoglobinopathies 330
Enrico M. Novelli

31 Heparin�]Induced Thrombocytopenia 341
Andreas Greinacher and Theodore E. Warkentin

32 Immunodeficiency and Immunoglobulin Therapy 357
Siraj A. Misbah

33 Transfusing Neonates and Infants 371
Ronald G. Strauss

Part V Patient Blood Management 383

34 Development of a Patient Blood Management Programme 383
Jonathan H. Waters

35 Perioperative Patient Blood Management 393
Martin Rooms, Ravishankar Rao Baikady and Toby Richards

36 Restrictive Transfusion Practice and How to Implement It 405
Lawrence Tim Goodnough and Neil Shah

37 Using Data to Support Patient Blood Management 416
Steven M. Frank and Jack O. Wasey

Part VI Cellular and Tissue Therapy and Organ Transplantation 429

38 Regulation and Accreditation in Cellular Therapy 429
Zbigniew (Ziggy) M. Szczepiorkowski and Daniel Hollyman

39 Stem Cell Collection and Therapeutic Apheresis 442
Khaled El�]Ghariani and Zbigniew (Ziggy) M. Szczepiorkowski

40 Haemopoietic Stem Cell Processing and Storage 455
Hira Mian, Ronan Foley and Pamela O’Hoski

41 Haematopoietic Stem Cell Transplantation 466
Robert D. Danby, Rachel Protheroe and David J. Roberts

42 Cord Blood Transplantation 477
Rachael Hough and Robert D. Danby

43 Recent Advances in Clinical Cellular Immunotherapy 490
Mark W. Lowdell and Emma Morris

44 Tissue Banking 500
Akila Chandrasekar, Paul Rooney and John N. Kearney

Part VII Development of the Evidence Base for Transfusion 508

45 Observational and Interventional Trials in Transfusion Medicine 508
Alan T. Tinmouth, Dean Fergusson and Paul C. Hébert

46 Getting the Most Out of the Evidence for Transfusion Medicine 520
Simon J. Stanworth, Susan J. Brunskill, Carolyn Dorée and Sally Hopewell

47 A Primer on Biostatistics 533
Andrew W. Shih and Nancy M. Heddle

48 A Primer on Health Economics 549
Seema Kacker and Aaron A. R. Tobian

49 Scanning the Future of Transfusion Medicine 560
Jay E. Menitove, Paul M. Ness and Edward L. Snyder

Index 572

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