Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions.

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease.

Visit the companion site to access supplementary materials including videos, editorial team details, downloadable figures, and more.

Clifford Rosen, M.D. is Director of the Center for Clinical and Translational Research at the Maine Medical Center Research Institute. Dr. Rosen is a former President of the American Society of Bone and Mineral Research. He serves as an Associate Editor on the Journal of Bone and Mineral Research and is former Editor of The Journal of Clinical Densitometry.

Section I: Molecular Cellular and Genetic Determinants of Bone Structure and Formation
Section Editor Karen Lyons
1 Skeletal Morphogenesis and Embryonic Development
Yingzi Yang
2 Signal Transduction Cascades Controlling Osteoblast Differentiation
David J.J. de Gorter and Peter ten Dijke
3 Osteoclast Biology and Bone Resorption
F. Patrick Ross
4 Osteocytes
Lynda F. Bonewald
5 Connective Tissue Pathways That Regulate Growth Factors
Gerhard Sengle and Lynn Y. Sakai
6 The Composition of Bone
Adele L. Boskey and Pamela Gehron Robey
7 Assessment of Bone Mass and Microarchitecture in Rodents
Blaine A. Christiansen
8 Animal Models: Genetic Manipulation
Karen Lyons
9 Animal Models: Allelic Determinants for BMD
Robert Blank
10 Neuronal Regulation of Bone Remodeling
Florent Elefteriou and Gerard Karsenty
11 Skeletal Healing
Michael J. Zuscik
12 Biomechanics of Fracture Healing
Elise F. Morgan and Thomas A. Einhorn
13 Human Genome-Wide Association (GWA) Studies
Douglas P. Kiel
14 Circulating Osteogenic Cells
Robert J. Pignolo and Moustapha Kassem

Section II: Skeletal Physiology
Section Editor Ego Seeman
15 Human Fetal and Neonatal Bone Development
Tao Yang, Monica Grover, Kyu Sang Joeng, and Brendan Lee
16 Skeletal Growth and Peak Bone Strength
Qingju Wang and Ego Seeman
17 Ethnic Differences in Bone Acquisition
SA Norris, LK Micklesfield, and JM Pettifor
18 Calcium and Other Nutrients During Growth
Tania Winzenberg and Graeme Jones
19 Growing a Healthy Skeleton: The Importance of Mechanical Loading
Mark R. Forwood
20 Pregnancy and Lactation
Christopher S. Kovacs and Henry M. Kronenberg
21 Menopause
Ian R. Reid

Section III: Mineral Homeostasis
Section Editor Ego Seeman
22 Regulation of Calcium and Magnesium
Murray J. Favus and David Goltzman
23 Fetal Calcium Metabolism
Christopher S. Kovacs
24 Fibroblast Growth Factor-23 (FGF23)
Kenneth E. White and Michael J. Econs
25 Gonadal Steroids
Stavros C. Manolagas, Maria Almeida, and Robert L. Jilka
26 Parathyroid Hormone
Robert A. Nissenson and Harald Jüppner
27 Parathyroid Hormone-Related Protein
John J. Wysolmerski
28 Ca2+-Sensing Receptor
Edward M. Brown
29 Vitamin D: Production, Metabolism, Mechanism of Action, and Clinical Requirements
Daniel Bikle, John Adams, and Sylvia Christakos

Section IV: Investigation of Metabolic Bone Diseases
Section Editor Doug Bauer
30 DXA in Adults and Children
Glen Blake, Judith Adams, and Nick Bishop
31 Quantitative Computed Tomography in Children and Adults
C.C. Glüer
32 Magnetic Resonance Imaging of Bone
Sharmila Majumdar
33 Radionuclide Scintigraphy in Metabolic Bone Disease
Gary J.R. Cook, Gopinath Gnanasegaran, and Ignac Fogelman
34 FRAX®: Assessment of Fracture Risk
John A Kanis
35 Biochemical Markers of Bone Turnover in Osteoporosis
Pawel Szulc, Douglas C Bauer, and Richard Eastell
36 Bone Biopsy and Histomorphometry in Clinical Practice
Robert R. Recker
37 Diagnosis and Classification of Vertebral Fracture
James F. Griffith, Judith E. Adams, and Harry K. Genant
38 Approaches to Genetic Testing
Christina Jacobsen, Yiping Shen, and Ingrid A. Holm

Section V: Osteoporosis
Section Editors Paul Miller and Socrates E. Papapoulos
39 Osteoporosis Overview
Michael Kleerekoper
40 The Epidemiology of Osteoporotic Fractures
Nicholas Harvey, Elaine Dennison, and Cyrus Cooper
41 Overview of Pathogenesis
Ian R. Reid
42 Nutrition and Osteoporosis
Connie M. Weaver and Robert P. Heaney
43 The Role of Sex Steroids in the Pathogenesis of Osteoporosis
Matthew T. Drake and Sundeep Khosla
44 Translational Genetics of Osteoporosis: From Population Association to Individualized Prognosis
Bich H. Tran, Jacqueline R. Center, and Tuan V. Nguyen
45 Prevention of Falls
Heike A Bischoff-Ferrari
46 Exercise and the Prevention of Osteoporosis
Clinton Rubin, Janet Rubin, and Stefan Judex
47 Calcium and Vitamin D
Bess Dawson-Hughes
48 Estrogens, Estrogen Agonist/Antagonists (Serms), and Calcitonin
Nelson B. Watts
49 Bisphosphonates for Postmenopausal Osteoporosis
Socrates E. Papapoulos
50 Denosumab
Michael R. McClung
51 Parathyroid Hormone Treatment for Osteoporosis
Felicia Cosman and Susan Greenspan
52 Strontium Ranelate in the Prevention of Osteoporotic Fractures
René Rizzoli
53 Combination Anabolic and Antiresorptive Therapy for Osteoporosis
John P. Bilezikian and Natalie E. Cusano
54 Compliance and Persistence with Osteoporosis Medications
Deborah T. Gold
55 Cost-Effectiveness of Osteoporosis Treatment
Anna N. A. Tosteson
56 Future Therapies of Osteoporosis
Kong Wah Ng and T. John Martin
57 Juvenile Osteoporosis
Nick Bishop and Francis Glorieux
58 Glucocorticoid-Induced Bone Disease
Robert S. Weinstein
59 Inflammation-Induced Bone Loss in the Rheumatic Diseases
Steven R. Goldring
60 Secondary Osteoporosis: Other Causes
Neveen A.T. Hamdy
61 Transplantation Osteoporosis
Peter R. Ebeling
62 Osteoporosis in Men
Eric S. Orwoll
63 Premenopausal Osteoporosis
Adi Cohen and Elizabeth Shane
64 Skeletal Effects of Drugs
Juliet Compston
65 Orthopedic Surgical Principles of Fracture Management
Manoj Ramachandran and David G. Little
66 Abnormalities in Bone and Calcium Metabolism After Burns
Gordon L. Klein

Section VI: Disorders of Mineral Homeostasis
Section Editor Marie Demay and Suzanne Jan de Beur
67 Approach to Parathyroid Disorders
John P. Bilezikian
68 Primary Hyperparathyroidism
Shonni J. Silverberg
69 Familial Primary Hyperparathyroidism (Including MEN, FHH, and HPT-JT)
Andrew Arnold and Stephen J. Marx
70 Non-Parathyroid Hypercalcemia
Mara J. Horwitz, Steven P. Hodak, and Andrew F. Stewart
71 Hypocalcemia: Definition, Etiology, Pathogenesis, Diagnosis, and Management
Anne Schafer and Dolores Shoback
72 Hypoparathyroidism and Pseudohypoparathyroidism
Mishaela R. Rubin and Michael A. Levine
73 Pseudohypoparathyroidism
Harald Jüppner and Murat Bastepe
74 Disorders of Phosphate Homeostasis
Mary D. Ruppe and Suzanne M. Jan de Beur
75 Vitamin D-Related Disorders
Paul V. Lips, Natasja M. van Schoor, and Nathalie Bravenboer
76 Vitamin D Insufficiency and Deficiency
J. Christopher Gallagher
77 Pathophysiology of Chronic Kidney Disease Mineral Bone Disorder (CKD–MBD)
Keith A. Hruska and Michael Seifert
78 Treatment of Chronic Kidney Disease Mineral Bone Disorder (CKD–MBD)
Hala M. Alshayeb, L. Darryl Quarles, and Hala M. Alshayeb
79 Disorders of Mineral Metabolism in Childhood
Thomas O. Carpenter
80 Paget’s Disease of Bone
Ethel S. Siris and G. David Roodman

Section VII: Cancer and Bone
Section Editor Theresa Guise
81 Overview of Mechanisms in Cancer Metastases to Bone
Gregory A. Clines
82 Clinical and Preclinical Imaging in Osseous Metastatic Disease
Geertje van der Horst and Gabri van der Pluijm
83 Metastatic Solid Tumors to Bone
Rachelle W. Johnson and Julie A. Sterling
84 Hematologic Malignancies and Bone
Rebecca Silbermann and G. David Roodman
85 Osteogenic Osteosarcoma
Jianning Tao, Yangjin Bae, Lisa L. Wang, and Brendan Lee
86 Skeletal Complications of Breast and Prostate Cancer Therapies
Catherine Van Poznak and Pamela Taxel
87 Bone Cancer and Pain
Patrick W. O’Donnell and Denis R. Clohisy
88 Radiation Therapy-Induced Osteoporosis
Jeffrey S. Willey, Shane A.J. Lloyd, and Ted A. Bateman
89 Skeletal Complications of Childhood Cancer
Ingrid A. Holm
90 Treatment and Prevention of Bone Metastases and Myeloma Bone Disease
Jean-Jacques Body
91 Radiotherapy of Skeletal Metastases
Edward Chow, Luluel M. Khan, and Øyvind S. Bruland
92 Concepts and Surgical Treatment of Metastatic Bone Disease
Kristy Weber and Scott Kominsky

Section VIII: Sclerosing and Dysplastic Bone Diseases
Section Editor Richard Keen
93 Sclerosing Bone Disorders
Michael P. Whyte
94 Fibrous Dysplasia
Michael T. Collins, Mara Riminucci, and Paolo Bianco
95 Osteochondrodysplasias
Yasemin Alanay and David L. Rimoin
96 Ischemic and Infiltrative Disorders
Richard W. Keen
97 Tumoral Calcinosis—Dermatomyositis
Nicholas Shaw
98 Fibrodysplasia Ossificans Progressiva
Frederick S. Kaplan, Robert J. Pignolo, and Eileen M. Shore
99 Osteogenesis Imperfecta
Joan C. Marini
100 Skeletal Manifestations in Marfan Syndrome and Related Disorders of the Connective Tissue
Emilio Arteaga-Solis and Francesco Ramirez
101 Enzyme Defects and the Skeleton
Michael P. Whyte

Section IX: Approach to Nephrolithiasis
Section Editor Rajesh Thakker
102 Renal Tubular Physiology of Calcium Excretion
Peter Friedman and David A. Bushinsky
103 Epidemiology of Nephrolithiasis
Murray J. Favus
104 Diagnosis and Evaluation of Nephrolithiasis
Stephen J. Knohl and Steven J. Scheinman
105 Kidney Stones in the Pediatric Patient
Amy E. Bobrowski and Craig B. Langman
106 Treatment of Renal Stones
John R. Asplin
107 Genetic Basis of Renal Stones
Rajesh V. Thakker

Section X: Oral and Maxillofacial Biology and Pathology
Section Editor Laurie McCauley
108 Development of the Craniofacial Skeleton
Maiko Matsui and John Klingensmith
109 Development and Structure of Teeth and Periodontal Tissues
Petros Papagerakis and Thimios Mitsiadis
110 Craniofacial Disorders Affecting the Dentition: Genetic
Yong-Hee P. Chun, Paul H. Krebsbach, and James P. Simmer
111 Pathology of the Hard Tissues of the Jaws
Paul C. Edwards
112 Bisphosphonate-Associated Osteonecrosis of the Jaws
Hani H. Mawardi, Nathaniel S. Treister, and Sook-Bin Woo
113 Periodontal Diseases and Oral Bone Loss
Mary K. Gray and Keith L. Kirkwood
114 Oral Manifestations of Metabolic Bone Diseases
Roberto Civitelli and Charles Hildebolt

Section XI: The Skeleton and Its Integration with Other Tissues
Section Editor Mone Zaidi
115 Central Neuronal Control of Bone Remodeling
Shu Takeda and Paul Baldock
116 The Pituitary–Bone Connection
Mone Zaidi, Li Sun, Terry F. Davies, Alberta Zallone, and Harry C. Blair
117 Skeletal Muscle Effects on the Skeleton
William J. Evans
118 Glucose Control and Integration by the Skeleton
Patricia Ducy and Gerard Karsenty
119 Obesity and Skeletal Mass
Sue Shapses and Deeptha Sukumar
120 Neuropsychiatric Disorders and the Skeleton
Itai Bab and Raz Yirmiya
121 Vascular Disease and the Skeleton
Dwight A. Towler
122 Spinal Cord Injury: Pathophysiology and Clinical Issues
William A. Bauman and Christopher P. Cardozo
123 Hematopoiesis and Bone
Benjamin J. Frisch and Laura M. Calvi
124 Bone and Immune Cell Interactions
Brendan F. Boyce