Principles of Biochemistry

Principles of Biochemistryprovides a concise introduction to fundamental concepts of biochemistry, striking the right balance of rigor and detail between the encyclopedic volumes and the cursory overview texts available today. Widely praised for accuracy, currency, and clarity of exposition, the Fifth Editionoffers a new student-friendly design, an enhanced visual program, new Application Boxes, contemporary research integrated throughout, and updated end-of-chapter problems.

Laurence A. Moran
After earning his Ph.D from Princeton University in 1974, Professor Moran spent four years at the Université dè Geneve in Switzerland. He has been a member of the Department of Biochemistry at the University of Toronto since 1978, specializing in molecular biology and molecular evolution. His research findings on heat-shock genes have been published in many scholarly journals.

H. Robert Horton
Dr. Horton, who received his Ph.D from the University of Missouri in 1962, is William Neal Reynolds Professor Emeritus and Alumni Distinguished Professor Emeritus in the Department of Biochemistry at North Carolina State University, where he served on the faculty for over 30 years. Most of Professor Horton’s research was in protein and enzyme mechanisms.

K. Gray Scrimgeour
Professor Scrimgeour received his doctorate from the University of Washington in 1961 and has been a faculty member at the University of Toronto since 1967. He is the author of The Chemistry and Control of Enzymatic Reactions (1977, Academic Press), and his work on enzymatic systems has been published in more than 50 professional journal articles during the past 40 years. From 1984—1992, he was editor of the journal Biochemistry and Cell Biology.

Marc D. Perry
After earning his Ph.D. from the University of Toronto in 1988, Dr. Perry trained at the University of Colorado, where he studied sex determination in the nematode C. elegans. In 1994 he returned to the University of Toronto as a faculty member in the department of Molecular and Medical Genetics. His research has focused on developmental genetics, meiosis and bioinformatics. In 2004 he joined the Heart & Stroke / Richard Lewar Centre of Excellence in Cardiovascular Research in the University of Toronto’s Faculty of Medicine.

(NOTE: Each chapter concludes with Summary, Problems, and Selected Reading.)

Part One: Introduction
1 Introduction to Biochemistry
2 Water

Part Two: Structure and Function
3 Amino Acids and the Primary Structures of Proteins
4 Proteins: Three-Dimensional Structure and Function
5 Properties of Enzymes
6 Mechanisms of Enzymes
7 Coenzymes and Vitamins
8 Carbohydrates
9 Lipids and Membranes

Part Three: Metabolism and Bioenergetics 
10 Introduction to Metabolism
11 Glycolysis
12 Gluconeogenesis, The Pentose Phosphate Pathway, and Glycogen Metabolism
13 The Citric Acid Cycle
14 Electron Transport and ATP Synthesis
15 Photosynthesis
16 Lipid Metabolism
17 Amino Acid Metabolism
18 Nucleotide Metabolism

Part Four: Biological Information Flow
19 Nucleic Acids
20 DNA Replication, Repair, and Recombination
21 Transcription and RNA Processing
22 Protein Synthesis