Progress in Nucleic Acid Research and Molecular Biology

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

ISBN: 9780125400718 | 0125400713
Cover: Hardcover
Copyright: 6/25/2002

Buy New

Print on Demand: 2-4 Weeks. This item cannot be cancelled or returned.

$187.91
eBook

Available Instantly

Online: 1825 Days

Downloadable: Lifetime Access

*To support the delivery of the digital material to you, a digital delivery fee of $3.99 will be charged on each digital item.

$210.00*

Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes.

Some Articles Planned for Future Volumes

DNA Modifications by Antitumor Platinum and Ruthenium Compounds: Their Recognition and Repair

(68)

Viktor Brabec

Introduction

(1)

Current State of Knowledge on DNA Interactions of ``Classical'' Antitumor Cisplatin and Its Clinically Ineffective trans Isomer

(22)

DNA Interactions of Cisplatin Analogs

(13)

Activation of trans Geometry

(4)

Polynuclear Platinum Antitumor Drugs

(7)

Antitumor Ruthenium Compounds

(5)

Concluding Remarks

(15)

References

(15)

AMP- and Stress-Activated Protein Kinases: Key Regulators of Glucose-Dependent Gene Transcription in Mammalian Cells?

(22)

Isabelle Leclerc

Gabriela da Silva Xavier

Guy A. Rutter

AMP-Activated Protein Kinase

(1)

SNF1 and Glucose Repression in Yeast

(1)

AMPK and Regulation of Gene Transcription in Mammals

(6)

Downstream Targets of AMPK and Gene Transcription

(1)

Mitogen- and Stress-Activated Protein Kinases

(4)

Conclusions

(9)

References

(9)

Molecular Basis of Fidelity of DNA Synthesis and Nucleotide Specificity of Retroviral Reverse Transcriptases

(58)

Luis Menendez-Arias

Introduction

(1)

The Role of Reverse Transcriptase in Retroviral Mutagenesis

(1)

Retroviral Reverse Transcriptases

(3)

Fidelity of Retroviral Reverse Transctiptases

(11)

Control of Fidelity at Initiation of Reverse Transcription

108

(1)

Fidelity of Strand Transfer: Implications for Retroviral Recombination

109

(1)

Contribution of Accessory Proteins to Fidelity of Reverse Transcription

110

(2)

Mutational Analysis of HIV-1 Reverse Transcriptase: The Effects of Mutations on Fidelity of DNA Synthesis

112

(17)

Biological Consequences of Increasing or Decreasing Fidelity

129

(2)

Conclusions and Future Perspectives

131

(18)

References

132

(17)

Muc4/Sialomucin Complex, the Intramembrane ErbB2 Ligand, in Cancer and Epithelia: To Protect and To Survive

149

(38)

Kermit L. Carraway

Aymee Perez

Nebila Idris

Scott Jepson

Maria Arango

Masanobu Komatsu

Bushra Haq

Shari A. Price-Schiavi

Jin Zhang

Coralie A. Carothers Carraway

Membrane Mucins

150

(3)

Muc4/SMC Structure and Functions

153

(7)

Muc4/SMC Contributions to Tumor Progression

160

(3)

Muc4/SMC in Simple Epithelia

163

(7)

Muc4/SMC in Glandular Secretory Epithelia

170

(7)

Muc4/SMC in Stratified Epithelia

177

(2)

Conclusions and Future Directions

179

(8)

References

180

(7)

Functions of Alphavirus Nonstructural Proteins in RNA Replication

187

(36)

Leevi Kaariainen

Tero Ahola

Introduction

187

(1)

Replication Cycle of Alphaviruses

188

(2)

Alphavirus-Like Superfamily

190

(2)

Replication of Alphavirus RNAs

192

(5)

Processing of Alphavirus Nonstructural Polyprotein P1234

197

(1)

nsP1: A Unique RNA-Capping Enzyme and Membrane Anchor

198

(6)

nsP2: A Multifunctional Enzyme and Regulatory Protein

204

(4)

nsP3: An Ancient Conserved Protein and Phosphoprotein

208

(2)

nsP4: A Catalytic RNA Polymerase Subunit

210

(1)

The Replication Complex

211

(12)

References

214

(9)

The Unique Biochemistry of Methanogenesis

223

(62)

Uwe Deppenmeier

Introduction

224

(1)

Methanogens: A Unique Group of Microorganisms

225

(3)

Biochemistry of Methanogenesis

228

(12)

Mechanism of ATP Synthesis in Methanogenic Archaea

240

(2)

Energy-Conserving Systems in Methanosarcina Strains

242

(28)

Energy Conservation in Obligate Hydrogenotrophic Methanogens

270

(15)

References

274

(11)

A History of Poly A Sequences: From Formation to Factors to Fuction

285

(106)

Mary Edmonds

Introduction

287

(3)

From Polymerases to Poly A(+) mRNA

290

(1)

Sequences Required for Polyadenylation

291

(5)

The Biochemistry of Polyadenylation

296

(10)

Cleavage/Polyadenylation Proteins

306

(7)

The Core Components of Cleavage/Polyadenylation

313

(7)

Cloning, Sequencing, and Expressing the Core Proteins

320

(15)

Regulation of Polyadenylation

335

(16)

Polyadenylation in Yeast

351

(13)

Polyadenylation in E. coli

364

(11)

Polyadenylation in Vaccinia Virus

375

(16)

References

381

(10)

A Growing Family of Guanine Nucleotide Exchange Factors Is Responsible for Activation of Ras-Family GTPases

391

(54)

Lawrence A. Quilliam

John F. Rebhun

Ariel F. Castro

Introduction

392

(2)

Regulation of in Vivo Ras-GTP Levels by Inhibition of GTPase-Activating Proteins

394

(1)

Early Identification of Ras-Family GEFs

395

(3)

GEF Structure and the Nucleotide Exchange Reaction

398

(6)

Dominant Inhibitory Ras Proteins Target GEFs

404

(2)

Biological Assays for GEF Activity

406

(1)

Ras-Family GEFs

407

(20)

GEFs and Disease

427

(1)

Are There More GEFs in Our Future?

428

(17)

References

428

(17)

Practical Approaches to Long Oligonucleotide-Based DNA Microarray: Lessons from Herpesviruses

445

(48)

Edward K. Wagner

J. J. Garcia Ramirez

S. W. Stingley

S. A. Aguilar

L. Buehler

G. B. Devi-Rao

Peter Ghazal

A Rationale for Developing DNA Microarrays for Herpesviruses

446

(1)

Herpes Simplex and Cytomegaloviruses---Two Herpesviruses That Share Features of Productive Infection but Differ Markedly in Patterns of Latency and Reactivation

447

(4)

Design Criteria for Herpesvirus DNA Microarrays

451

(4)

The Construction and Validation of an Oligonucleotide-Based Hsv-1 DNA Microarray on Glass Slides

455

(17)

Exemplary Applications

472

(14)

Conclusions

486

(7)

References

487

(6)

Sphingosine Kinases: A Novel Family of Lipid Kinases

493

(20)

Hong Liu

Debyani Chakravarty

Michael Maceyka

Sheldon Milstien

Sarah Spiegel

Pleiotropic Functions of Sphingosine-1-Phosphate

494

(1)

Sphingosine Kinase and Sphingosine-1-Phosphate in Yeast and Plants

495

(2)

Cellular Functions of Sphingosine Kinase in Mammalian Cells

497

(1)

How Is Sphingosine Kinase Activated?

498

(2)

Cloning of Mammalian Sphingosine Kinases

500

(4)

Sphingosine Kinase Family

504

(1)

Five Conserved Domains of the SPHK Superfamily

505

(3)

Phylogenetic Analysis of Sphingosine Kinases

508

(1)

Concluding Remarks

508

(5)

References

509

(4)

Mechanisms of EF-Tu, a Pioneer GTPase

513

(40)

Ivo M. Krab

Andrea Parmeggiani

Introduction

514

(10)

Structure-Function Relationships

524

(5)

EF-Ts as a Steric Chaperone for EF-Tu Folding

529

(2)

EF-Tu as Target of Antibiotics

531

(7)

Specific Aspects of EF-Tu GTPase Activity

538

(4)

Conclusions and Perspectives

542

(11)

References

543

(10)

Index

553

Please wait while the item is added to your bag...

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Progress in Nucleic Acid Research and Molecular Biology

Summary

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Progress in Nucleic Acid Research and Molecular Biology

Summary

Table of Contents

Supplemental Materials

Digital License