Psychopharmacology of Antipsychotics

Another distinctive handbook, this covers all the classes of antipsychotics currently available and clearly explains the complex pharmacological mechanisms involved in the actions of the different classes.

Introduction

Four Key Neurotransmitter Systems: Mediators of antipsychotic psychopharmacology

Dopamine

Serotonin

Serotonin-dopamine interactions

Acetylcholine

Dopamine-acetylcholine interactions

Glutamate

Symptoms and Pathophysiology of Schizophrenia

Positive symptoms

Dopamine hypothesis of positive symptoms

Negative symptoms

Cognitive symptoms

Aggressive symptoms

Mood and anxiety symptoms

Neurodevelopmental hypotheses

Neurodegenerative hypotheses

Conventional Antipsychotics: the classical neuroleptics

Nonselective D2

Antihistamine, anticholinergic, α1-antagonist

Dopamine-acetylcholine imbalance

Tardive dyskinesia

Phenothiazines

Thioxanthines

Butyrophenones

Heterocyclics

Atypical Antipsychotics and Serotonin-Dopamine Antagonism

List of agents, new and old

Properties: improved EPS (extrapyramidal symptoms), lower prolactin, improved negative symptoms

Serotonin-dopamine antagonism in the striatum

PET (positron emission tomography) scans

Serotonin-dopamine antagonism in the pituitary

Serotonin-dopamine antagonism in the cortex

Beyond the SDA (serotonin-dopamine antagonism) Concept: how individual atypical antipsychotics differ

Clozapine

Risperidone

Olanzapine

Quetiapine

Sertindole

Ziprasidone

Loxapine

Zotepine

Differential pharmacologies

Clinical pearls

Dosage tips

The Cytochrome P450 (CYP) System and Pharmacokinetic Considerations for Atypical Antipsychotics

Preventing unwanted pharmacokinetic interactions

Role of 1A2

Role of CYP 2D6

Role of CYP 2C

Role of CYP 3A4

Pharmacokinetic pearls

Antipsychotic summary

Treatment of positive symptoms

Treatment of negative symptoms

Treatment of cognition, hostility, aggression and mood

Clinical trials vs. clinical practice

Managing inadequate treatment responses

References

Index

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Psychopharmacology of Antipsychotics

Summary

Table of Contents

Supplemental Materials