Quality in Laboratory Hemostasis and Thrombosis

Dr Steve Kitchen, Clinical Scientist, Sheffield Hemophila and Thromobosis Centre, Royal Hallamshire Hospital and Scientific Director, UK National External Quality Assessment Scheme (FQAS) for Blood Coagulation, Scientific Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK.

John D Olson, Professor and Vice Chair for Clinical Affairs, Department of Pathology, University of Texas Health Sciences Centre, San Antonio, Texas, USA.

F. Eric Preston, Emeritus Professsor of Hematology, University of Sheffield and Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulations, Sheffield, UK.

Contributors

Foreword by Frits R. Rosendaal

Preface

Part 1: General Quality Program

1 General Quality Planning in the Hemostasis Laboratory
John D. Olson

2 Hemostasis Test Validation, Performance and Reference Intervals: International Recommendations and Guidelines
Richard A. Marlar

3 Causes of Errors in Medical Laboratories
Giuseppi Lippi, Emmanuel J. Favaloro

4 International Standards in Hemostasis
Trevor W. Barrowcliffe, Anthony R. Hubbard

5 Sample Integrity and Pre-analytical Variables
Dorothy (Adcock) Funk

6 Internal Quality Control in the Hemostasis Laboratory
Steve Kitchen, F. Eric Preston, John D. Olson

7 External Quality Assessment in Hemostasis: Its Importance and Significance
F. Eric Preston, Steve Kitchen, Alok Srivastava

8 The Unique Challenges of Hemostatic Testing in Children
M. Patricia Massicotte, Mary E. Bauman, Vanessa Chan, Anthony K.C. Chan

Part 2: Quality in Coagulation Testing

9 Initial Evaluation of Hemostasis: Reagent and Method Selection
Wayne L. Chandler

10 Assay of Factor VIII and Other Clotting Factors
Steve Kitchen, F. Eric Preston

11 Application of Molecular Genetics to the Investigation of Inherited Bleeding Disorders
Stefan Lethagen, Morten Dunø, Lars Bo Nielsen

12 Detecting and Quantifying Acquired Functional Inhibitors in Haemostasis
Bert Verbruggen, Myriam Dardikh, Britta Laros-van Gorkom

13 Standardisation of D-dimer Testing
Guido Reber, Philippe de Moerloose

14 Point-of-Care Testing in Hemostasis
Chris Gardiner, Dianne Kitchen, Samuel Machin, and Ian Mackie

Part 3: Quality in Testing for Platelet Function and von Willebrand Disease

15 Diagnostic Assessment of Platelet Function
Paquita Nurden, Alan Nurden, Martine Jandrot-Perrus

16 Laboratory Evaluation of Heparin-Induced Thrombocytopenia
Theodore (Ted) E. Warkentin, Jane C. Moore

17 Laboratory Evaluation of von Willebrand Disease: Phenotypic Analysis
Emmanuel J. Favaloro

18 Laboratory Analysis of von Willebrand Disease: Molecular Analysis
Anne C. Goodeve, Ian R. Peake

Part 4: Quality in Thrombophilia Testing and Monitoring Anticoagulation

19 Quality Issues in Heritable Thrombophilia Testing
Isobel D. Walker, Ian Jennings

20 Evaluation of Antiphospholipid Antibodies
Michael Greaves

21 Monitoring Heparin Therapy
Marilyn Johnston

22 Monitoring Oral Anticoagulant Therapy with Vitamin K Antagonists
Armando Tripodi

23 Monitoring New Anticoagulants
Elaine Gray, Steve Kitchen

Index

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