Quantitative Modeling in Toxicology

, by Krishnan, Kannan; Andersen, Melvin E.

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ISBN: 9780470998090 | 0470998091
Cover: Hardcover
Copyright: 5/3/2010

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Governments around the world are passing laws requiring industry to assess the toxicity of the chemicals/products they produce. To meet these requirements, experimental toxicologists and risk assessors are adopting quantitative approaches and computer simulations to study the biological fate and effects of chemicals and drugs. Written by leading experts in the field who contribute their own models, codes and examples, Quantitative Modeling in Toxicology outlines the current state of knowledge on the modeling of dose, tissue interactions and tissue responses. A Web site containing computer modeling codes, templates and examples that can be used by toxicologists accompanies the book.

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Preface	p. ix
About the Editors	p. xi
About the Book	p. xiii
List of Contributors	p. xv
Introduction
Quantitative Modeling in Toxicology: An Introduction	p. 3
Physiologically-Based Toxicokinetic and Pharmacokinetic(PBPK)Modeling
PBPK Modeling: A Primer	p. 21
Pharmacokintic Modeling of Manganese - An Essential Element	p. 59
Physiologically Based Modeling of Pharmacokinetic Interactions in Chemical Mixtures	p. 83
Physiological Parameters and Database for PBPK Modeling	p. 107
Modeling Toxicant-Target Interactions
Modeling Cholinesterase Inhibition	p. 137
Modeling of Protein Induction and Dose-Dependent Hepatic Sequestration	p. 167
Bistable signaling Motifs and Cell Fate Decisions	p. 181
Ultrasensitive Response Motifs in Biochemical Networks	p. 199
Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks	p. 219
Modeling Liver and Kidney Cytotoxicity	p. 235
Modeling Tissue and Organism Responses
Computational Model for Iodide Economy and the HPT Axis in the Adult Rat	p. 253
Two Stage Clonal Growth Modeling of Cancer	p. 269
Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures	p. 283
(Q)SAR Models of Adverse Responses Acute Systemic Toxicity	p. 299
Model Application and Evaluation
Modeling Exposures to Chemicals From Multiple Sources and Routes	p. 317
Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data	p. 353
Quantitative Modeling in Noncancer Risk Assessment	p. 371
Application of Physiologically Based Pharmacokinetic Modeling in Health Risk Assessment	p. 399
Uncertainity, Variability, and Sensitivity Analyses in Simulation Models	p. 429
Evaluation of Quantitative Models in Toxicology: Progress and Challenges	p. 459
Index	p. 477
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Quantitative Modeling in Toxicology

Summary

Author Biography

Table of Contents

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Quantitative Modeling in Toxicology

Summary

Author Biography

Table of Contents

Supplemental Materials

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