Quinones and Quinone Enzymes, Part B

Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers the role of quinines enzymes in cellular signalling and modulation of gene expression.

CONTRIBUTORS TO VOLUME 382

xi

PREFACE

xv

VOLUMES IN SERIES

xvii

Section I. Mitochondrial Ubiquinone and Reductases

1. Mitochondrial Quinone Reductases: Complex I

GIORGIO LENAZ, ROMANA FATO, ALESSANDRA BARACCA, AND MARIA LUISA GENOVA

3

(18)

2. Q-cycle Bypass Reactions at the Q0 Site of the Cytochrome bc1 (and Related) Complexes

DAVID M. KRAMER, ARTHUR G. ROBERTS, FLORIAN MULLER, JONATHAN CAPE, AND MICHAEL K. BOWMAN

21

(24)

3. Targeting Coenzyme Q Derivatives to Mitochondria

ROBIN A. J. SMITH, GEOFFREY F. KELSO, ANDREW M. JAMES, AND MICHAEL P. MURPHY

45

(22)

4. The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia

CONSTANZA L. LISDERO, MARIA CECILIA CARRERAS, ALAIN MEULEMANS, MARIANA MELANI, MICHEL AUBIER, JORGE BOCZKOWSKI, AND JUAN JOSE PODEROSO

67

(14)

5. Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency

PIERRE RUSTIN, ARNOLD MUNNICH, AND AGNES RÖTIG

81

(8)

6. Coenzyme Q Cytoprotective Mechanisms

TOM S. CHAN, JOHN X. WILSON, AND PETER J. O'BRIEN

89

(16)

7. Dietary Coenzyme Q10 and Mitochondrial Status

CHING KUANG CHOW

105

(10)

Section II. Anticancer Quinones and Quinone Oxidoreductases

8. NAD(P)H: Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics

DAVID ROSS AND DAVID SIEGEL

115

(29)

9. Structure and Mechanism of NAD[P]H: Quinone Acceptor Oxidoreductases (NQO)

MARIO A. BIANCHET,MARGARITA FAIG, AND L. MARIO AMZEL

144

(30)

10. Diaziridinylbenzoquinones

ANGELA DI FRANCESCO, TIMOTHY H. WARD, AND JOHN BUTLER

174

(20)

11. Quinone Reductase-Mediated Nitro-Reduction: Clinical Applications

RICHARD J. KNOX AND SHIUAN CHEN

194

(27)

12. Bioactivation and Resistance to Mitomycin C

HELEN A. SEOW, PHILIP G. PENKETH, RAYMOND P. BAUMANN, AND ALAN C. SARTORELLI

221

(13)

13. NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells

ROSARIO I. BELLO, CONSUELO GOMEZ-DIAZ, PLÁCIDO NAVAS, AND JOSÈ M. VILLALBA

234

(9)

14. The "Prochaska" Microtiter Plate Bioassay for Inducers of NQO1

JED W. FAHEY, ALBENA T. DINKOVA-KOSTOVA, KATHERINE K. STEPHENSON, AND PAUL TALALAY

243

(15)

15. Structure-Activity Relationships in Two-Electron Reduction of Quinones

NARIMANTAS CENAS, ZILVINAS ANUSEVICIUS, HENRIKAS NIVINSKAS, LINA MISEVICIENE, AND JONAS SARLAUSKAS

258

(20)

16. p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 1

GAD ASHER, JOSEPH LOTEM, LEO SACHS, AND YOSEF SHAUL

278

(15)

17. The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerative Diseases

ERCOLE CAVALIERI, ELEANOR ROGAN, AND DHRUBAJYOTI CHAKRAVARTI

293

(27)

18. Induction of NQO1 in Cancer Cells

ASHER BEGLEITER AND JEANNE FOURIE

320

(35)

Section III. Quinone Reductases: Chemoprevention and Nutrition

19. Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection Against Toxicity of Electrophiles and Reactive Oxygen Intermediates

PAUL TALALAY AND ALBENA T. DINKOVA-KOSTOVA

355

(9)

20. Activation and Detoxification of Naphthoquinones by NAD(P)H:Quinone Oxidoreductase

REX MUNDAV

364

(16)

21. Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens

YOUNG-HWA KANG AND JOHN M. PEZZUTO

380

(34)

22. Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 Enzymes

MI-KYOUNG KWAK, MINERVA RAMOS-GOMEZ, NOBUNAO WAKABAYASHI, AND THOMAS W. KENSLER

414

(9)

23. Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)

ALBENA T.KINKOVA-KOSTOVA, JED W. FAHAEY, AND PAUL TALALAY

423

(26)

24. Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An Overview

REX MUNDAY AND CHRISTINE M. MUNDAY

449

(8)

25. Upregulation of Quinone Reductase by Glucosinolate Hydrolysis Products from Dietary Broccoli

ELIZABETH H. JEFFERY AND KRISTIN E. STEWART

457

(16)

Section IV. Quinones and Age-Related Diseases

26. Therapeutic Effects of Coenzyme Q10 in Neurodegenerative Diseases

M. FLINT BEAL

473

(15)

27. Neuroprotective Actions of Coenzyme Q10 in Parkinson's Disease

S. SHARMA, M. KHERADPEZHOU, S. SHAVALI, H. EL REFAEY, J. EKEN, C. HAGEN, AND M. EBADI

488

(23)

AUTHOR INDEX

511

(50)

SUBJECT INDEX

561

What is included with this book?

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Quinones and Quinone Enzymes, Part B

Summary

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Quinones and Quinone Enzymes, Part B

Summary

Table of Contents

Supplemental Materials

Digital License