RADIOIMMUNOTHERAPY OF CANCER

Reflecting the past 20 years of intense research in radioimmunotherapy, this timely reference surveys an expansive breadth of topics on the evolving developments in radiation therapy. Placed in the context of advances in cancer treatment, chapters progress systematically from basic principles and properties of radionuclides to detailed summaries of current cancer therapies. Up to date, clearly organized, and thorough-sure to become a standard in the field! Providing comprehensive treatment on radiolabeled antibody therapy, Radioimmunotherapy of Cancer reviews dosimetric principles and clinical dosimetry of radioimmunotherapy in the targeting and delivery of radiation describes tumor architectures and outlines novel constructs for radionuclide delivery analyzes a variety of improved targeting approaches, including pretargeting contextual analysis of extracorporeal techniques in radioimmunotherapy details studies from the radiotherapy of lymphoma, solid tumors, and ovarian cancer and the targeted radiotherapy of neuroblastoma and squamous head and neck cancer and much more! With contributions from nearly 50 international experts and containing over 1300 literature references, drawings, photographs, tables, and equations, Radioimmunotherapy of Cancer is an invaluable and indispensable reference for physicians in nuclear medicine and medical physicists; oncologists, radiologists, radiochemists, and radiopharmacists; immunologists, pulmonologists, and cancer researchers; pharmacologists and drug delivery pharmaceutical chemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Paul G. Abrams, M.D., J.D. CEO, NeoRx Corporation, Seattle, Washington Donald B. Axworthy: Senior Scientist, Pharmacology, NeoRx Corporation, Seattle, Washington Paul L. Beaumier, Ph.D.: Scientist, Toxicology Department, Shin Nippon Biomedical Sciences USA, Everett, Washington Ruud H. Brakenhoff, Ph.D.: Assistant Professor, Department of Otolaryngology/Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands Hazel B. Breitz, M.D.: Research Affiliate, Nuclear Medicine Section, Virginia Mason Medical Center, Seattle, Washington Oyvind S. Bruland, M.D., Ph.D.: Professor and Consultant Oncologist, Departments of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo, Norway Donald J. Buchsbaum, Ph.D.: Professor and Director of Radiation Biology, Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama JianQing Chen, Ph.D. Department of Biochemistry, University of Missouri, Columbia, Missouri. Marco Chinol, Ph.D.: Chief Radiochemist, Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy Marta Cremonesi, Ph.D.: Physicist, Division of Medical Physics, European Institute of Oncology, Milan, Italy Remco de Bree, M.D., Ph.D.: E.N.T. Surgeon, Department of Otolaryngology/Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands G. L. DeNardo, M.D.: Professor Emeritus, Internal Medicine, Radiology and Pathology, University of California, Davis, California Ann M. Dvorak, M.D.: Department of Pathology, Beth Israel Deaconess Medical Center, and Professor of Pathology, Harvard Medical School, Boston, Massachusetts Harold F. Dvorak, M.D.: Chief, Department of Pathology, Beth Israel Deaconess Medical Center, and Mallinckrodt Professor of Pathology, Harvard Medical School, Boston, Massachusetts Agamemnon A. Epenetos, Ph.D., F.R.C.P.: Chief Scientific Officer, Antisoma Research Laboratories, St. George's Hospital Medical School, London, England Dian Feng, Ph.D.: Department of Pathology, Beth Israel Deaconess Medical Center, and Instructor in Pathology, Harvard Medical School, Boston, Massachusetts Alan R. Fritzberg, Ph.D.: Chief Scientist, NeoRx Corporation, Seattle, Washington Michael Garkavij, M.D., Ph.D.: Consultant Oncologist, Department of Oncology, Lund University Hospital, Lund, Sweden Roberto Gennari, M.D. Attending Surgeon, Division of Surgical Oncology, Department of Surgery, European Institute of Oncology, Milan, Italy J. G. Geraghty Division of Surgical Oncology, Department of Surgery, European Institute of Oncology, Milan, Italy Chiara Grana, M.D. Assistant, Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy John W. Greiner, Ph.D. Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Patricia Horan Hand, Ph.D. Oncological Sciences Initial Review Group, Center for Scientific Review, National Institutes of Health, Bethesda, Maryland Cecilia Hindorf, M.Sc. Department of Radiation Physics, Jubileum Institute, Lund University, Lund, Sweden Cornelis A. Hoefnagel, M.D., Ph.D. Department of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, The Netherlands Susan J. Knox, M.D., Ph.D. Associate Professor, Department of Radiation Oncology, Stanford University, Stanford, California Monica S. Krieger Corixa Corporation, Seattle, Washington Claude F. Meares, Ph.D. Professor and Chairman, Department of Chemistry, University of California, Davis, California Ruby F. Meredith, M.D., Ph.D. Professor, Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama Janice A. Nagy, Ph.D. Department of Pathology, Beth Israel Deaconess Medical Center, and Senior Research Associate, Harvard Medical School, Boston, Massachusetts Rune Nilsson, Ph.D. Mitra Medical Technology AB, Lund, Sweden Joseph A. O'Donoghue, Ph.D.: Assistant Attending Physicist, Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York Giovanni Paganelli, M.D.: Division Director, Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy Alexander Pihl, M.D., Ph.D.: Professor Emeritus, Department of Biochemistry, Norwegian Radium Hospital, Oslo, Norway O. Press, M.D., Ph.D.: Professor in Medicine and Biological Structures, University of Washington, and Member, Fred Hutchinson Cancer Research Center, Seattle, Washington Jasper J. Quak, M.D., Ph.D.: Department of Otolaryngology/Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands Bengt E. B. Sandberg: Mitra Medical Technology AB, Lund, Sweden Jody E. Schultz, Ph.D.: Research Manager, Molecular Biology, NeoRx Corporation, Seattle, Washington Hans-Olov Sjogren, M.D., Ph.D.: Department of Tumorimmunology, Lund University, Lund, Sweden Dale C. Slavin-Chiorini, Ph.D.: Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Gordon B. Snow, M.D., Ph.D.: Professor and Chairman, Department of Otolarynology/Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands Sven-Erik Strand, M.B., Ph.D.: Professor, Radiation Physics, Jubileum Institute, Lund University, Lund, Sweden Konstantinos N. Syrigos, M.D., Ph.D.: Associate Professor of Medical Oncology and Consultant, Third Department of Medicine, University of Athens Medical School, Athens, Greece Jan G. Tennvall, M.D., Ph.D.: Consultant Oncologist and Nuclear Medicine Physician, Department of Oncology, Lund University Hospital, Lund, Sweden Louis J. Theodore, Ph.D.: Senior Scientist, Chemistry, NeoRx Corporation, Seattle, Washington Guus A. M. S. van Dongen, Ph.D.: Department of Otolaryngology/Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands Frank B. van Gog, Ph.D.: Department of Otolaryngology/Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands Gerard W. M. Visser, Ph.D.: Radio Nuclide Center, Free University Hospital, Amsterdam, The Netherlands Paul L. Weiden, M.D.: Medical Director, Cancer Clinical Research Unit, Virginia Mason Medical Center, Seattle, Washington Michael R. Zalutsky, Ph.D.: Professor, Department of Radiology, Duke University Medical Center, Durham, North Carolina