Redox-Genome Interactions in Health and Disease

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ISBN: 9780824740481 | 0824740483
Cover: Hardcover
Copyright: 9/12/2003

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At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a host of monogenetic and polygenetic diseases.

Series Introduction (Lester Packer and Enrique Cadenas)

iii

Preface

vii

Contributors

xiii

I. The Cellular Redox Status and Gene Regulation System

1. Redox-Genome Interactions: Evolution of a Concept

(12)

Jürgen Fuchs, Maurizio Podda, R. Kaufmann, and Lester Packer

2. Measurements of Biological Reducing Power by Voltammetric Methods

(30)

Ron Kohen, Eitan Moor, and Miriam Oron

3. Composition and Regulation of Thiol-Disulfide Redox State

(18)

Yvonne S. Nkabyo, Thomas R. Ziegler, and Dean P. Jones

4. Thiols and Thioredoxin in Cellular Redox Control

(18)

Hajime Nakamura, Norihiko Kondo, Kiichi Hirota, Hiroshi Masutani, and Junji Yodoi

5. Role of Free Radicals and Cellular Redox Status in Signal Transduction and Gene Expression

(22)

Wulf Dröge and Wulf Hildebrandt

6. Redox Regulation of Apoptosis

101

(22)

Marie-Véronique Clément and Shazib Pervaiz

7. Mitochondria, Aging, and Disease: A Genomic Perspective

123

(22)

Stefano Salvioli, Massimiliano Bonafè, Cristiana Barbi, Miriam Capri, Daniela Monti, and Claudio Franceschi

8. The Human Genome as a Target of Oxidative Modification: Damage to Nucleic Acids

145

(48)

Jean Cadet, Thierry Douki, and Jean-Luc Ravamt

9. Redox Modulation in Tumor Initiation, Promotion, and Progression

193

(24)

Margaret Hanausek, Zbigniew Walaszek, and Thomas J. Slaga

10. The Potential Impact of Polymorphism on Oxidative Stress Status

217

(18)

Louise Lyrenäs, Emma Wincent, Lena Forsberg, Ulf de Faire, and Ralf Morgenstern

II. Oxidative Stress in Genetic Diseases

11. Mitochondrial Dysfunction in Genetic Diseases

235

(28)

Immo E. Scheffler

12. Oxidative and Nitrosative Stress in Cystic Fibrosis: Significance or Triviality?

263

(24)

Brian M. Morrissey, Albert van der Vliet, Jason Eiserich, and Carroll E. Cross

13. Oxyradicals in Iron Overload Syndromes: Hemochromatosis

287

(18)

Shinya Toyokuni

14. Oxidative Imbalance in Hereditary Hemoglobinopathies: The Role of Reactive Oxygen Species in the Pathophysiology of Sickle Cell Anemia and Thalassemie

305

(20)

Jürgen Fuchs, Maurizio Podda, and Eliezer A. Rachmilewitz

15. Association of Oxidative Stress with Cataractogenesis

325

(26)

Marjorie F. Lou

16. Oxidative Stress and Age-Related Macular Degeneration

351

(26)

Paul S. Bernstein, Jerusha L. Nelson, Jessica L. Burrows, and E. Wayne Askew

17. Retinitis Pigmentosa: A Potential Role for Reactive Oxygen and Nitrogen Species During Photoreceptor Apoptosis

377

(32)

Maryanne Donavan and Thomas G. Cotter

18. The Role of Oxidative Imbalance in the Pathogenesis of Down Syndrome

409

(16)

Ting-Ting Huang, Sailaja Mentha, and Charles J. Epstein

19. Metal Homeostasis and Its Relation to Oxidative Stress in Alzheimer's Disease

425

(14)

Adam D. Cash, Ravi Srinivas, Catherine A. Rottkamp, Xiongwei Zhu, Marta A. Taddeo, Gjumrakch Aliev, Hisashi Fujioka, Craig S. Atwood, Lawrence M. Sayre, Rudolph J. Castellani, Mark A. Smith, George Perry, and Akihiko Nunomura

20. Oxidative Stress and Huntington's Disease

439

(34)

C. Turner and Anthony H. V. Schapica

21. Oxidative Stress in Familial Amyotrophic Lateral Sclerosis

473

(24)

Diane E. Cabelli

22. Oxidants and Antioxidants in the Pathology of Colon Cancer

497

(16)

William L. Stone, K. Krishnan, and Andreas M. Papas

23. The Role of Oxidative Imbalance in Diabetes Mellitus

513

(28)

Dominique Bonnefont-Rousselot, Alain Legrand, and Jacques Delattre

24. The Role of Reactive Oxygen Species, the Renin-Angiotensin System, and Endothelin in the Development of Essential Hypertension

541

(16)

Jane F. Reckelhoff, Laurent Juillard, and J. Carlos Romero

25. Oxidative Stress in Cardiovascular Disease: Role of Oxidized Lipoproteins in Macrophage Foam Cell Formation and Atherosclerosis

557

(34)

Michael Aviram and Mira Rosenblat

26. Free Radicals in Rheumatoid Arthritis: Mediators and Modulators

591

(20)

Tulin Bodamyali, Janos M. Kanczler, Tim M. Millar, Cliff R. Stevens, and David R. Blake

Index

611

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Redox-Genome Interactions in Health and Disease

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