Reproductive and Developmental Toxicology

Offers extensive discussions on the pharmacological, environmental, endocrinological, & natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes.

Foreword

iii

(2)

Bernard A. Schwetz

Preface

v

(6)

Contributors

xi

Part I. Development and Neurotoxicity

1

(258)

1. Mullerian-Inhibiting Substance Activity and Normal Male Sex Determination

1

(10)

David T. MacLaughlin

Patricia K. Donahoe

2. Effects of Environmental Chemicals on Early Development

11

(36)

Rama S. Dwivedi

Philip M. Iannaccone

3. Developmental Toxicology

47

(26)

John M. Rogers

Robert J. Kavlock

4. Malformations in Pregastrulation Developmental Toxicology

73

(14)

Joe C. Rutledge

Walderico M. Generoso

5. Developmental Effects of Dioxins

87

(26)

Linda S. Birnbaum

6. Transgenic and Knockout Mice: Genetic Models for Environmental Stress

113

(30)

Robert S. Tebbs

Jack B. Bishop

Roger A. Pedersen

7. Genes and Reproductive Behavior Resulting from Normal or Abnormal Development

143

(10)

Sonoko Ogawa

Donald W. Pfaff

8. Reproductive Neuroendocrine Regulation in the Female: Toward a Neurochemical Mechanism for the Preovulatory Luteinizing Hormone Surge

153

(42)

William R. Crowley

9. The Hypothalamus and Pituitary as Targets for Reproductive Toxicants

195

(16)

Ralph L. Cooper

Jerome M. Goldman

Lee Tyrey

10. Developmental Neurotoxicology

211

(38)

Gaylia Jean Harry

11. Lead Neuroendocrine Toxicology

249

(10)

Rebecca Z. Sokol

Part II. Female Reproduction

259

(216)

12. Female Reproduction and Toxicology of Estrogen

259

(18)

James H. Clark

13. Phytoestrogens and Reproductive Medicine

277

(22)

Claude L. Hughes, Jr.

Ginger Tansey

14. Human Health and Phytoestrogens

299

(74)

Herman Adlercreutz

15. Ovarian Toxicants: Multiple Mechanisms of Action

373

(24)

Barbara J. Davis

Jerrold J. Heindel

16. Toxicology of Early Pregnancy, Implantation, and Uterine Function

397

(16)

Audrey M. Cummings

17. TCDD and Uterine Function

413

(18)

Kimberly Silvers

Ellen A. Rorke

18. Antiestrogenic Activity of TCDD and Related Compounds

431

(18)

Timothy Zacharewski

Stephen H. Safe

19. Reproductive and Developmental Toxicity of Metals: Issues for Consideration in Human Health Risk Assessments

449

(26)

Rafael A. Ponce

Elaine M. Faustman

Part III. Male Reproduction

475

(218)

20. The Biology of the Male Reproductive Tract

475

(34)

Michael J. McPhaul

21. Reciprocal Mesenchymal-Epithelial Interactions in the Development of the Male Urogenital Tract

509

(22)

Gerald R. Cunha

Annemarie A. Donjacour

Simon W. Hayward

22. Influence of Estrogenic Agents on Mammalian Male Reproductive Tract Development

531

(22)

Retha R. Newbold

23. Toxicology of the Male Excurrent Ducts and Accessory Sex Glands

553

(40)

Gary R. Klinefelter

Rex A. Hess

24. Developmental Male Reproductive Toxicology of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and PCBs

593

(32)

Beth L. Roman

Richard E. Peterson

25. Toxicity of Spermatogenesis and Its Detection

625

(10)

Richard M. Sharpe

26. Gamete Toxicology: The Impact of New Technologies

635

(20)

Sally D. Perreault

27. Sertoli Cell Toxicants

655

(38)

Ling-Hong Li

Jerrold J. Heindel

Index

693

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Reproductive and Developmental Toxicology

Summary

Table of Contents

Supplemental Materials

FREE SHIPPING

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Reproductive and Developmental Toxicology

Summary

Table of Contents

Supplemental Materials

Digital License