Schizophrenia And Manic-depressive Disorder

An important contribution to the ongoing debate over the origins of mental illness, this book is based on the largest study ever of identical twins in which one was ill and the other not. The book provides compelling evidence that both schizophrenia and manic-depressive disorder are biologically based diseases of the brain, unrelated to psychological influences.

About the Authors

xi

Contributing Researchers

xiii

Preface

xix

Acknowledgments

xxi

List of Tables

xxiii

List of Illustrations and Figures

xxv

The Politics and Science of Twin Studies

1

(12)

Are Identical Twins Really Identical?

13

(12)

Methodology of the Study

25

(17)

When Does Schizophrenia Originate?

42

(37)

Are Individuals Who Develop Schizophrenia Different as Children?

79

(23)

Does Schizophrenia Change the Structure of the Brain?

102

(14)

Does Schizophrenia Change the Function of the Brain?

116

(28)

Does Schizophrenia Change the Underlying Personality?

144

(6)

When Both Twins Get Schizophrenia, Are Their Diseases Similar?

150

(21)

How Different Are Twins with Bipolar Disorder from Twins with Schizophrenia?

171

(13)

Triplets and Beyond

184

(14)

What Do Twin Studies Tell Us About the Causes of Schizophrenia?

198

(12)

Summary of Major Findings

210

(4)

Appendix A: Final Diagnostic Groups

214

(6)

Appendix B: Neuropsychological Examination

220

(3)

Appendix C: Neurological Examination

223

(3)

Appendix D: Personality Inventory for Children

226

(2)

Glossary

228

(3)

Bibliography

231

(31)

Index

262

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Schizophrenia And Manic-depressive Disorder The Biological Roots Of Mental Illness As Revealed By The Landmark Study Of Identical Twins

Summary

Table of Contents

Supplemental Materials