Mrna Metabolism & Post-Transcriptional Gene

Post-transcriptional reactions have been implicated in a number of clinical conditions (e.g. lupus, and rheumatoid arthritis), and regulatory mechanisms are the target of potential therapeutic strategies. This book provides a comprehensive overview of the various modes of gene regulation that exist post-transcriptionally. It uses selected well-characterized examples to illustrate the generally applicable principles for regulation that exist throughout the life of an RNA molecule.

Joe B. Harford and David R. Morris are the authors of mRNA Metabolism & Post-Transcriptional Gene Regulation, published by Wiley.

Partial table of contents:

RNA Structure (E. Puglisi & J. Puglisi).

Transcription and Transcriptional Control: An Overview (I. Olave, et al.).

Constitutive and Alternative mRNA Splicing (S. Bernstein & D. Hodges).

mRNA Polyadenylation: Functional Implications (E. Baker).

RNA Export from the Nucleus (L. Maquat).

The Intracellular mRNA Sorting System: Postal Codes, Zip Codes, Mail Bags and Mail Boxes (O. Steward & R. Singer).

The Fundamentals of Translation Initiation (H. Huang & T. Donahue).

Mechanisms of mRNA Turnover in Eukaryotic Cells (S. Tharun & R. Parker).

Control of mRNA Decay in Plants (A. van Hoof & P. Green).

mRNA Metabolism and Cancer (M. Korth & M. Katze).

Translational Regulation in Animal Virus-Infected Cells (R. Schneider).

RNA Decay by the Interferon-Regulated 2-5A System as a Host Defense Against Viruses (R. Silverman & N. Cirino).

Control of mRNA Stability During Herpes Simplex Virus Infection (G. Read).

Regulation of mRNA Expression in HIV-1 and Other Retroviruses (B. Felber).

Index.

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Mrna Metabolism & Post-Transcriptional Gene Regulation

Summary

Author Biography

Table of Contents

Supplemental Materials