Multiple Sclerosis and CNS Inflammatory Disorders

Multiple Sclerosis and CNS Inflammatory Disorders is a practical guide to effective care of patients with multiple sclerosis and other neuroimmunologic and CNS inflammatory disorders.

It provides the scientific basis of multiple sclerosis including etiology, epidemiology, and pathogenesis. It covers the diagnostic process, the course of the disease and prognosis, and the use of MRI in diagnosis and disease monitoring. Disease-modifying  treatment algorithms for relapsing-remitting multiple sclerosis, switching therapy, and progressive multiple sclerosis treatment algorithms are all discussed in detail. It also addresses multiple sclerosis in childhood and pregnancy and includes assessment of alternative therapies.

This new addition to the Neurology in Practice series contains practical guidance and learning features:

• Algorithms and guidelines

• “Tips and Tricks” boxes on improving outcomes

• “Caution” warning boxes to avoiding problems

• “Science Revisited”—quick reminders of the basic science principles necessary for understanding

Multiple Sclerosis and CNS Inflammatory Disorders is an ideal reference for neurologists in practice and training.

Lawrence M. Samkoff, MD, Associate Professor of Neurology at the School of Medicine and Dentistry, University of Rochester Medical Center,  Rochester, NY, USA

Andrew D. Goodman, MD, Professor of Neurology, Chief of the Neuroimmunology Unit, and Director of the Multiple Sclerosis Center at the School of Medicine and Dentistry, University of Rochester Medical Center , Rochester, NY, USA

Contributors vii

Series Foreword x

Preface xi

chapter 1 1

Etiology
Sonya U. Steele and Ellen M. Mowry

chapter 2 10

Immunopathogenesis of Multiple Sclerosis
Anne H. Cross and Laura Piccio

chapter 3 18

Diagnostic Process
Dalia Rotstein and Paul O’Connor

chapter 4 29

MRI in Diagnosis and Disease Monitoring
María I. Gaitán and Daniel S. Reich

chapter 5 45

Relapsing MS: Disease Staging and Therapeutic Algorithms
Mohsen Khoshnam and Mark Freedman

chapter 6 57

Progressive MS Treatment Algorithms
Megan H. Hyland and Jeffrey A. Cohen

chapter 7 67

Sex-Determined Issues in Multiple Sclerosis
Callene Momtazee and Barbara Giesser

chapter 8 77

Pediatric Multiple Sclerosis
Robert Thompson Stone and Brenda Banwell

chapter 9 91

Complementary and Alternative Medicine: Risks and Benefits
Allen C. Bowling

chapter 10 102

Symptomatic Management of MS
Jessica Robb, Lawrence M. Samkoff, and Andrew D. Goodman

chapter 11 114

Invisible Symptoms of MS: Fatigue, Depression, and Cognition
Leigh E. Charvet, Benzi Kluzer, and Lauren B. Krupp

chapter 12 122

Rehabilitation
Nesanet S. Mitiku, Alexius E. G. Sandoval, and George H. Kraft

chapter 13 134

Psychosocial Adaptation to Multiple Sclerosis
David J. Rintell

chapter 14 144

Transverse Myelitis and Acute Disseminated Encephalomyelitis
Benjamin M. Greenberg

chapter 15 153

Neuromyelitis Optica
Marcelo Matiello and Brian G. Weinshenker

chapter 16 163

Neurosarcoidosis
Thomas F. Scott

chapter 17 169

Lyme Neuroborreliosis
Erica Patrick and Eric Logigian

chapter 18 178

Neuro-Behçet Syndrome
Aksel Siva and Sabahattin Saip

Index 191

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