Synapses

Edited by W. Maxwell Cowan, Thomas C. Südhof, and Charles F. Stevens, this volume provides a comprehensive and authoritative overview of a century of research on synaptic structure and function culminating in the most recent work. Written by leading experts in the field, Synapses will be of interest to a broad range of neuroscientists, including those studying the cellular and molecular mechanisms of synaptic transmission, learning and memory, neuronal plasticity, neurotransmitters, and synaptic morphology. It will also be an essential reference for students and biomedical professionals in all areas of neuroscience.

W. Maxwell Cowan (1932-2002) was an internationally renowned neurobiologist and the chief scientific officer at the Howard Hughes Medical Institute (HHMI) in Chevy Chase, Maryland. Thomas C. S++dhof is an HHMI investigator and professor of molecular genetics at the University of Texas Southwestern Medical Center at Dallas. Charles F. Stevens is an HHMI investigator at the Salk Institute for Biological Studies and adjunct professor of Pharmacology and of Neuroscience at the University of California, San Diego, School of Medicine.

Preface

vii

Contributors

xi

A Brief History of Synapses and Synaptic Transmission

1

(88)

W. Maxwell Cowan

Eric R. Kandel

The Structure of Synapses

89

(46)

Pietro De Camilli

Volker Haucke

Kohji Takei

Enrico Mugnaini

Physiology of Synaptic Transmission and Short-Term Plasticity

135

(42)

Wade G. Regehr

Charles F. Stevens

Mechanism and Regulation of Neurotransmitter Release

177

(40)

Thomas C. Sudhof

Richard H. Scheller

Synaptic Vesicle Endocytosis

217

(58)

Pietro De Camilli

Vladimir I. Slepnev

Oleg Shupliakov

Lennart Brodin

The Synaptic Cleft and Synaptic Cell Adhesion

275

(40)

Thomas C. Sudhof

The Postsynaptic Specialization

315

(42)

Morgan H.-T. Sheng

Signal Transduction in the Postsynaptic Neuron

357

(36)

Activity-Dependent Regulation of Gene Expression

Michael E. Greenberg

Edward B. Ziff

Synaptic Plasticity

393

(62)

Diverse Targets and Mechanisms for Regulating Synaptic Efficacy

Robert C. Malenka

Steven A. Siegelbaum

The Mechanisms and Meaning of Long-Term Synaptic Depression in the Mammalian Brain

455

(64)

Mark F. Bear

David J. Linden

Synaptic Plasticity and Memory

519

(52)

Paul D. Grimwood

Stephen J. Martin

Richard G. M. Morris

Synapse Formation and Maturation

571

(42)

Ann Marie Craig

Jeff W. Lichtman

Neurotrophins and Refinement of Visual Circuitry

613

(38)

Edward S. Lein

Carla J. Shatz

Novel Neurotransmitters and Their Neuropsychiatric Relevance

651

(30)

Solomon H. Snyder

Christopher D. Ferris

Synaptic Variability

681

(52)

New Insights from Reconstructions and Monte Carlo Simulations with MCell

Joel R. Stiles

Thomas M. Bartol

Miriam M. Salpeter

Edwin E. Salpeter

Terrence J. Sejnowski

Index

733

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Summary

Author Biography

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

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Synapses

Summary

Author Biography

Table of Contents

Supplemental Materials

Digital License