Sepsis and Multiorgan Failure

, by Fein, Alan; Abraham, Edward M.; Balk, Robert A.; Bernard, Gordon R.; Bone, Roger C.

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ISBN: 9780683030976 | 0683030973
Cover: Hardcover
Copyright: 7/1/1997

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State Univ. of New York, Stony Brook. Synthesis of the basic science and clinical concepts of treating sepsis and multiorgan failure. For practitioners, basic scientists, and epidemiologists. 100 contributors, 73 U.S. DNLM: Sepsis--complications.

Preface

vii

(2)

Acknowledgments

(2)

Contributors

1. Epidemiology and Microbiology

(42)

Roger C. Bone

1. Systemic Inflammatory Response Syndrome: A Unifying Concept of Systemic Inflammation

(8)

Roger C. Bone

2. Mechanisms and Classification of Shock

(11)

Mark E. Astiz

Eric C. Rackow

3. Microbiology of Sepsis

(5)

Gordon M. Trenholme

4. The Epidemiology and Natural History of Bacterial Sepsis

(8)

M. Sigfrido Rangel-Frausto

Richard P. Wenzel

5. The Epidemiology of Sepsis in the Immunocompromised Host

(8)

Lisa H. Youkeles

Mark J. Rosen

2. Molecular and Biochemical Mechanisms

(110)

Edward M. Abraham

6. Endotoxin and Sepsis

(17)

Peter S. Dahlberg

David L. Dunn

7. Gram Positive Organisms and the Pathology of Sepsis

(12)

Ilona Idanpaan-Heikkila

Elaine Tuomanen

8. Cellular Effectors of the Septic Process

(26)

Randeep S. Jawa

Joseph S. Solomkin

9. Cytokine Networks in the Pathogenesis of Sepsis

100

(10)

Larry C. Casey

10. Mediators of SIRS: The Kallikrein/Kinin System and Catecholamines

110

(6)

Timothy C. Rodell

11. Fatty Acids and Prostaglandins as Mediators of the Septic Response

116

(8)

Michel A. Makhlouf

James A. Cook

Perry V. Halushka

12. Nitric Oxide Biology in Sepsis and Shock States

124

(15)

Jose A. Lorente

Luis Landin

Andres Esteban

13. Oxygen Radicals in Sepsis, Acute Lung Injury, and Multiple Organ Failure

139

(14)

Stuart Horowitz

Lin Mantell

3. Tissue and Organ Response to Sepsis

153

(114)

David R. Dantzker

14. Acute Respiratory Failure in Sepsis

155

(13)

Jane E. Dematte

Michelle L. Barnard

J. Iasha Sznajder

15. Liver Dysfunction in Sepsis

168

(13)

George M. Matuschak

16. Energetics and Oxygen Delivery in Sepsis

181

(8)

David E. Taylor

Guillermo Gutierrez

17. Multiple Organ Dysfunction Syndrome: The Relevance of Persistent Infection and Inflammation

189

(20)

R. D. Piper

William J. Sibbald

18. Cardiac Dysfunction in Sepsis

209

(11)

Jean-Francois Dhainaut

Alain Cariou

Virginie Gest

19. Substrate Use in Hypermetabolism

220

(16)

Joshua A. Katz

Stephen F. Lowry

20. Neurologic Alterations in Sepsis

236

(7)

Thomas P. Bleck

21. Acute Renal Failure in Sepsis and Shock

243

(12)

Paul L. Bernstein

Richard H. Sterns

22. Coagulopathy: Disseminated Intravascular Coagulation

255

(12)

Tom van der Poll

Marcel Levi

Sander J. H. van Deventer

4. Diagnosis and Prognosis

267

(114)

Alan M. Fein

23. Diagnostic Approach and Clinical Manifestations of Severe Sepsis

269

(8)

John C. Rodrigues

Alan M. Fein

24. Circulating Markers of Sepsis and Acute Lung Injury

277

(9)

Polly E. Parsons

Marc Moss

25. Criteria for the Description of Organ Dysfunction in Sepsis and SIRS

286

(11)

John C. Marshall

26. Severe Sepsis in Infants and Children

297

(13)

Jonathan M. Davis

Pramod Narula

Jane Aronson

Daniel Hirsch

27. Severe Pneumonia

310

(17)

Michael S. Neiderman

Antonio Torres

28. Imaging in Sepsis

327

(10)

Murray M. Arons

Arthur P. Wheeler

29. Evaluation of Cardiovascular Performance in Sepsis

337

(18)

Jason M. Lazar

30. Use of Nuclear Medicine Techniques in the Diagnosis and Evaluation of Sepsis

355

(18)

Elizabeth Yung

Holley M. Dey

31. Sepsis in the Geriatric Age Group

373

(8)

Bruce P. Krieger

5. Surgical Aspects of Sepsis

381

(114)

Mitchell P. Fink

32. Gut Barrier Dysfunction and Sepsis

383

(25)

Mitchell P. Fink

Jonathan S. Aranow

33. Trauma and Burns

408

(11)

H. Hank Simms

34. Sepsis in the Gynecological and Obstetric Patient

419

(12)

Stephen E. Lapinsky

P. Gareth R. Seaward

35. Abdominal Sepsis

431

(10)

John M. A. Bohnen

36. Urologic Sepsis

441

(10)

Michael A. O'Donnell

6. Therapeutic Approach

451

(128)

Robert A. Balk

37. Ventilatory Management of Sepsis-associated Respiratory Distress Syndrome

453

(9)

Jesus Villar

Arthur S. Slutsky

38. Pharmacologic Management of Shock: Support of the Cardiovascular System

462

(5)

Jean-Louis Vincent

39. A Care Map for Severe Sepsis

467

(8)

Janice L. Zimmerman

R. Phillip Dellinger

40. Improving Oxygen Delivery

475

(8)

David R. Dantzker

41. Antimicrobial Therapy of Sepsis

483

(11)

Burke A. Cunha

M. Vanessa Gill

42. Fluids and Resuscitation in Sepsis

494

(9)

Mark E. Astiz

Victor Castro

Eric C. Rackow

43. Biological Response Modifiers and Sepsis

503

(16)

Bennett P. deBoisblanc

Benoit Guery

Steve Nelson

44. The Economics and Cost-effectiveness of Sepsis

519

(7)

Donald B. Chalfin

45. Ethical Considerations in Sepsis and Multiorgan Failure

526

(11)

Sharon Einav

Charles L. Sprung

46. Metabolic and Nutritional Support in SIRS and Sepsis

537

(9)

Akram S. Talhouk

Lillian Harvey

Patricia Molina

Marius Chagoury

Naji N. Abumrad

47. Acute Renal Failure in Sepsis and Multiple Organ Failure

546

(11)

Howard L. Corwin

48. Inhaled Nitric Oxide: A Therapeutic Tool in Acute Lung Injury

557

(22)

Louis Puybasset

Jean-Jacques Rouby

7. New Frontiers in Sepsis

579

(56)

Gordon R. Bernard

49. Design and Conduct of Clinical Trials in Sepsis and Critical Illness

581

(6)

Gordon R. Bernard

50. Use of Evidence-based Medicine in Evaluation of Sepsis Therapies

587

(9)

Deborah Cook

51. Animal Models of Sepsis and Septic Shock

596

(18)

Mitchell P. Fink

Aaron G. Baggs

52. Statistical Issues in Clinical Sepsis Trials

614

(13)

Stanley Lemeshow

Daniel Teres

Scott Moseley

53. Interpreting Large-scale Clinical Sepsis Trials: A Retrospective View

627

(8)

Charles J. Fisher, Jr.

Yunli Zheng

Index

635

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Sepsis and Multiorgan Failure

Summary

Table of Contents

Supplemental Materials