Signal Transduction: Principles, Pathways, and Processes

Preface

Foreword
Edmond Fischer

SECTION I. GENERAL PRINCIPLES AND MECHANISMS
1 Signals and Receptors
Carl-Henrik Heldin, Benson Lu, Ron Evans, and J. Silvio Gutkind

2 Protein Regulation in Signal Transduction
Michael J. Lee and Michael B. Yaffe

3 Second Messengers
Alexandra C. Newton, Martin D. Bootman, and John D. Scott

4 Signaling Networks: Information Flow, Computation, and Decision Making
Evren U. Azeloglu and Ravi Iyengar

SECTION II. SIGNALING PATHWAYS

MAP Kinase Pathways
Deborah K. Morrison

The PI3K-PKB/Akt Pathway
Brian A. Hemmings and David F. Restuccia

mTOR Signaling
Mathieu Laplante and David M. Sabatini

Calcium Signaling
Martin D. Bootman

The Cyclic AMP Pathway
Paolo Sassone-Corsi

Wnt Signaling
Roel Nusse

Hedgehog Signaling
Philip W. Ingham

Notch Signaling
Raphael Kopan

Signaling by the TGFb Superfamily
Jeffrey L. Wrana

The JAK/STAT Pathway
Douglas A. Harrison

Toll-Like Receptor Signaling
Kian-Huat Lim and Louis M. Staudt

Immunoreceptor Signaling
Lawrence E. Samelson

Signaling by Nuclear Receptors
Richard Sever and Christopher K. Glass

The Hippo Pathway
Kieran F. Harvey and Iswar K. Hariharan

SECTION III. SIGNALING PROCESSES

5 Signaling Pathways that Control Cell Proliferation
Robert J. Duronio and Yue Xiong

6 Signaling Pathways that Regulate Cell Division
Nicholas Rhind and Paul Russell

7 Signaling in Control of Cell Growth and Metabolism
Patrick S. Ward and Craig B. Thompson

8 Signaling Networks that Regulate Cell Migration
Peter Devreotes and Alan Rick Horwitz

9 Signaling Pathways in Cell Polarity
Luke Martin McCaffrey and Ian G. Macara

10 Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning
Norbert Perrimon, Chrysoula Pitsouli, and Ben-Zion Shilo

11 Signaling by Sensory Receptors
David Julius and Jeremy Nathans

12 Synaptic Signaling in Learning and Memory
Mary B. Kennedy

13 Signaling in Muscle Contraction
Ivana Y. Kuo and Barbara E. Ehrlich

14 Organismal Carbohydrate and Lipid Homeostasis
D. Grahame Hardie

15 Signaling in Innate Immunity and Inflammation
Kim Newton and Vishva M. Dixit

16 Signaling in Lymphocyte Activation
Doreen Cantrell

17 Vertebrate Reproduction
Sally Kornbluth and Rafael Fissore

18 Cell Signaling and Stress Responses
Gökhan S. Hotamisligil and Roger J. Davis

19 Cell Death Signaling
Douglas R. Green and Fabien Llambi

20 Subversion of Cell Signaling by Pathogens
Neal M. Alto and Kim Orth

21 Signal Transduction in Cancer
Richard Sever and Joan S. Brugge

22 Outlook
Jeremy Thorner, Tony Hunter, Lewis C. Cantley, and Richard Sever

Index