Single-use Technology in Biopharmaceutical

This book gives an overview of commonly-used disposables in the manufacture of biopharmaceuticals, their working principles, characteristics, engineering aspects, economics, and applications. With this information, readers will be able to come to an easier decision for or against disposable alternatives and to choose the appropriate system. The book is divided into two parts the first is related to basic knowledge about disposable equipment; and the second discusses applications through case studies that illustrate manufacturing, quality assurance, and environmental influence.

Regine Eibl is a professor at the Zurich University of Applied Sciences (Switzerland), where she lectures in biotechnology and cell cultivation techniques.

Dieter Eibl is a professor at the Zurich University of Applied Sciences, where he lectures in biochemical engineering and the planning of biotechnological production facilities.

Basics
Single-use equipment in biopharmaceutical manufacture: A brief introduction
Single-use bag systems for storage, transportation, freezing and thawing
Bag mixing systems for single-use
Single-use bioreactors - an overview
Systems for coupling and sampling
Disposable sensor systems
Bio-informatics and single-use
Single-use downstream equipment
Single-use technology for formulation and filling application
Production of disposable Bags: A manufacturer's report
Disposable filter devices
Biopharmaceutical manufacturing facilities integrating single-use systems
An introduction to the validation and qualification of disposables used in biomanufacture - a user's perspective
Waste generation, treatment options and the environmental impact of single use systems
Next generation single-use bioreactor technology and the future of biomanufacturing: A summary from manufacturer's and user's perspective Single-Use Technology in Biopharmaceutical Manufacture
Application reports and case studies
Disposable SuperSpinner: Characteristics and typical applications
A new scale-down approach for the rapid development of Sf21/BEVS-based processes - a case study
Practical aspects of establishing pharmaceutical recombinant proteins from research to development in disposable bioreactors
Single-use stirred tank reactor BIOSTAT CultiBag STR: Characterization and applications
Single-use bioreactor platform for microbial fermentation
Growth of BY-2 suspension cells and plantibody production in single-use bioreactors
CFD as a tool to characterize single-use bioreactors
Automated disposable systems: Application reports
New single-use sensors for online measurement of glucose and lactate, the answer to the PAT Initiative
Disposable Chromatography for large-scale biomanufacturing
Single-use virus clearance technologies in biopharmaceutical manufacturing: Case studies
A single-use technology platform for downstream processing: Mobius FlexReady Solutions
The manufacture of MAbs - a comparison of performance and process time between traditional and ready-to-use, disposable systems
Going fully disposable - current possibilities: A case study from Crucell
Production Costs in Biotech Facilities: Single Use vs. Multiple Use Equipment for Antibody Manufacture
Table of Contents provided by Publisher. All Rights Reserved.

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Single-use Technology in Biopharmaceutical Manufacture

Summary

Author Biography

Table of Contents

Supplemental Materials