Skin Lymphoma The Illustrated Guide

Skin Lymphoma: The Illustrated Guide presents a templated, easy to follow approach to the diagnosis of this challenging condition. Hundreds of outstanding full colour images, carefully chosen for their clinical relevance, are complemented by a standard chapter format which covers clinical features, histopathology, diagnosis, treatment and prognosis. Teaching cases throughout the text highlight examples of particular interest for trainees, and summary boxes highlight key points for quick review.

This new fourth edition has been fully updated in line with new WHO classifications, and includes over 100 new photographs. The Pseudolymphomas section has been greatly expanded, with separate chapters for each type to assist in differential diagnosis, and new “Unconventional Features” are included throughout the book.

Lorenzo Cerroni, Professor of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
Professor Cerroni is the Director of both the Cutaneous Lymphoma Unit and the Dermatopathology Research Center at the University of Graz. He is a former president of the International Society of Dermatopathology (2001-2004).

List of teaching cases, vii

Preface, ix

Acknowledgments, xi

1 Introduction, 1

Section 1: Cutaneous NK/T-cell lymphomas

2 Mycosis fungoides, 11

3 Sézary syndrome, 74

4 Primary cutaneous CD30+ lymphoproliferative disorders, 85

Lymphomatoid Papulosis, 86

Cutaneous Anaplastic Large Cell Lymphoma, 99

“Borderline” Cases, 109

5 Subcutaneous panniculitis-like T-cell lymphoma, 120

6 Aggressive cutaneous cytotoxic lymphomas, 133

Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma, 134

Primary Cutaneous γ/δ T-cell Lymphoma, 137

Cutaneous Extranodal NK/T-cell Lymphoma, Nasal Type, 143

7 Cutaneous peripheral T-cell lymphoma, not otherwise specifi ed (NOS), 155

8 Cutaneous CD4+ small–medium T-cell lymphoma, 163

Indolent CD8+ Lymphoid Proliferation of the Ear (Face), 166

Primary Cutaneous T-follicular helper (TFH)-cell Lymphoma, 167

9 Cutaneous adult T-cell leukemia/lymphoma, 172

10 Other cutaneous NK/T-cell lymphomas, 176

Angioimmunoblastic T-cell Lymphoma, 176

Hydroa Vacciniforme-Like Lymphoma, 179

Section 2: Cutaneous B-cell lymphomas

11 Cutaneous follicle center lymphoma, 185

12 Cutaneous marginal zone lymphoma (cutaneous MALT-lymphoma) and variants, 201

Cutaneous Marginal Zone Lymphoma, Conventional Variant, 202

Cutaneous Marginal Zone Lymphoma, Lymphoplasmacytic Variant, 208

Cutaneous Marginal Zone Lymphoma, Plasmacytic Variant, 212

Cutaneous Marginal Zone Lymphoma, Blastoid Variant, 213

13 Cutaneous diff use large B-cell lymphoma, leg type, 220

14 Intravascular large cell lymphomas, 232

Intravascular Large B-cell Lymphoma, 232

Intravascular Large NK/T-cell Lymphoma, 237

Intralymphatic CD30+ Large T-cell Lymphoma, 239

15 Other cutaneous B-cell lymphomas, 245

Cutaneous EBV+ Diff use Large B-cell Lymphoma of the Elderly, 245

Specific Cutaneous Manifestations in Mantle Cell Lymphoma, 247

Specific Cutaneous Manifestations in Extracavitary Primary Effusion Lymphoma, 248

Specific Cutaneous Manifestations in Multiple Myeloma, 250

Specific Cutaneous Manifestations in Burkitt Lymphoma, 252

Cutaneous Lymphomatoid Granulomatosis, 253

Cutaneous Plasmablastic Lymphoma, 256

Cutaneous T-cell/Histiocyte-rich B-cell Lymphoma, 258

Section 3: Cutaneous lymphomas in immunosuppressed individuals

16 Cutaneous post-transplant lymphoproliferative disorders, 265

17 Cutaneous lymphomas in HIV-infected individuals, 275

18 Cutaneous lymphoproliferative disorders in other iatrogenic and non-iatrogenic immune deficiencies, 281

Section 4: Specific cutaneous manifestations of leukemias and of precursor hematologic neoplasms

19 Cutaneous manifestations of B-cell chronic lymphocytic leukemia, 287

20 Cutaneous manifestations of myelogenous leukemia, 296

21 Blastic plasmacytoid dendritic cell neoplasm, 306

22 Cutaneous manifestations of other leukemias, 317

T-cell Prolymphocytic Leukemia, 317

Aggressive Natural Killer Cell Leukemia, 318

Specific Skin Manifestations of other Types of Leukemia, 319

23 Cutaneous lymphoblastic lymphomas, 320

Cutaneous B-lymphoblastic Lymphoma, 320

Cutaneous T-lymphoblastic Lymphoma, 323

Section 5: Cutaneous manifestations of Hodgkin lymphoma

24 Cutaneous manifestations of Hodgkin lymphoma, 331

Section 6: Cutaneous lymphomas in children and adolescents

25 Cutaneous lymphomas in children and adolescents, 341

Section 7: Pseudolymphomas of the skin

26 Pseudolymphomas of the skin, 351

Actinic reticuloid, 353

Lymphomatoid contact dermatitis, 354

Solitary idiopathic B/T-cell pseudolymphoma, 355

Lichenoid (lymphomatoid) keratosis, 357

Lichen aureus/lichenoid pigmented purpuric dermatitis, 357

Lichen sclerosus, 359

Vitiligo, 360

Annular lichenoid dermatitis of youth, 361

Pseudolymphomatous acrodermatitis chronica atrophicans, 361

Pseudolymphomatous atopic dermatitis, 362

Non-neoplastic erythroderma in adult patients, 363

Pseudolymphomatous cutaneous infiltrates in human immunodeficiency virus (HIV)-infected patients and in other immune deficiencies, 367

CD30+ T-cell pseudolymphomas, 367

Persistent nodular arthropod bite reactions and nodular scabies, 369

Pseudolymphomas in herpes simplex and herpes zoster infections, 371

Epstein–Barr virus (EBV)-associated mucocutaneous ulcers, 372

Hydroa vacciniforme, 373

Pityriasis lichenoides, 374

Pseudolymphomas associated with lupus erythematosus, 376

Lymphomatoid drug reactions, 379

Lymphocytoma cutis, 380

Pseudolymphomas at sites of vaccination, 384

Pseudolymphomas in tattoos, 385

Localized scleroderma/morphea, 386

Cutaneous IgG4-related disease, 386

Pseudolymphomas in syphilis, 386

Cutaneous plasma cell granuloma, 388

Cutaneous and systemic plasmacytosis, 389

Cutaneous manifestations of Castleman disease, 392

Pre-tibial lymphoplasmacytic plaque in children, 393

Cutaneous extramedullary hematopoiesis, 394

Histiocytoid Sweet syndrome, 395

Intralymphatic histiocytosis, 396

Benign intralymphatic proliferation of T-cell lymphoid blasts, 397

Other “accidental” pseudolymphomas, 398

“Malignant” pseudolymphomas, 399

Section 8: The cutaneous “atypical lymphoid proliferation”

27 The cutaneous “atypical lymphoid proliferation”, 413

Index, 415

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