Small Angle X-ray and Neutron Scattering from Solutions of Biological Macromolecules

Dmitri I. Svergun, Group Leader and Senior Scientist, European Molecular Biology Laboratory, Hamburg,Michel H. J. Koch, Department of Chemistry, University of Leuven,Peter A. Timmins, Long-term Visitor, Institut Laue-Langevin, Grenoble,Roland P. May, Long-term Visitor, Institut Laue-Langevin, Grenoble

Dmitri I.Svergun: MSc in Solid state physics (1980), Physics Department, Moscow State University, Russia; PhD in Physics and Mathematics (1982) and Dr. of Science (1997), Institute of Crystallography, Moscow, Russia; Engineer, Researcher, Senior Scientist at the Institute of Crystallography, Russian Academy of Sciences, Moscow (1980 - 2008); Guest scientist, GKSS Research Centre, Geesthacht, Germany (1990-1991); Visitor, Staff Scientist, Group Leader, at the European Molecular Biology Laboratory Hamburg Outstation (1991-present).

Michel, H.J. Koch: PhD in chemistry, University of Louvain (1970), Neutron scattering on biological macromolecules in solution (1974-1976). Consultant (1975-1976), Group leader at the European Molecular Biology Laboratory outstation at DESY, Hamburg (1977-2006), Visiting professor at the Faculty of Engineering and Natural Science, Sabanci University, Turkey (2008-2009) and the Chemistry Department, University of Leuven (2006 - present).

Roland May: Diploma in Physics (Technische Universitat Munchen); Thesis work at the Max-Planck Institut fur Biochemie, Martinsried; PhD Technische Universitat Munchen 1978; scientist in the Large-Scale Structures group of the Institut Laue-Langevin, Grenoble until 2008; retired.

Peter Timmins: BSc in Chemistry (1967), MSc in Crystallography (1968) and PhD in Crystallography (1972) - Birkbeck College, University of London. Instrument Scientist, Institut Laue-Langevin, 1975 - 1993, Head, Large Scale Structures Group, Institut Laue-Langevin, 1993 - 2010. Since 2010, retired.

Introduction
PART I. THEORY AND EXPERIMENT
1. Basics of small-angle scattering
2. X-ray and neutron scattering instruments
3. Experimental practice and data processing
PART II. DATA ANALYSIS METHODS
4. Monodisperse systems
5. Polydisperse and interacting systems
PART III. BIOLOGICAL APPLICATIONS OF SOLUTION SAS
6. Static structral studies
7. Kinetic and perturbation studies
8. Analysis of interparticle interactions
9. SAS in multidisciplinary studies
Conclusions and future outlook
Appendix 1: Waves, complex number, Fourier transforms, convolution, correlation
Appendix 2: Spherical harmonics formalism
Appendix 3: Interactions between spherical molecules
Appendix 4: List of Web resources