Solid-Phase Synthesis: A Practical Guide

This hands-on reference tool provides the most up-to-date information needed to synthesize molecules by solid-phase synthesis (SPS)-employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. The volume presents new strategies for creating a wide variety of compounds invaluable for drug discovery in coming years. Thoroughly analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules. Written by 35 internationally recognized authorities, Solid-Phase Synthesis provides experimental procedures and a literature review for peptides, DNA, PNA, carbohydrates, peptidomimetics, and small molecule assembly describes the preparation of solid supports and handles (linkers) as well as their appropriate incorporation into a synthetic strategy discusses methods for the construction of more complex peptides: cyclic (lactam and disulfide), glyco-, phospho-, sulfo- and nucleopeptides explains the pro

Fernando Albericio: Department of Organic Chemistry, University of Barcelona, Spain Nicholas P. Ambulos, Jr.: Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore David Andreu: Department of Organic Chemistry, University of Barcelona, Spain George Barany: Department of Chemistry, University of Minnesota, Minneapolis Laurent Bellon: Department of Oligonucleotide Chemistry, Ribozyme Pharmaceuticals, Inc., Boulder, Colorado Lisa Bibbs: Protein and Nucleic Acids Core Facility, The Scripps Research Institute, La Jolla, California Christopher Blackburn: Drug Discovery, Millennium Pharmaceuticals, Cambridge, Massachusetts Lynda F. Bonewald: Department of Medicine/Endocrinology, The University of Texas Health Science Center at San Antonio Ralph A. Casale: Core PNA Research and Development, PE Biosystems, Framingham, Massachusetts Scott B. Daniels: Instrument Development, PE Biosystems, Framingham, Massachusetts Vern de Biasi: Analytical Sciences, SmithKline Beecham Pharmaceuticals, Essex, England Amanda L. Doherty-Kirby: Department of Chemistry, University of Waterloo, Ontario, Canada Michael Egholm: Core PNA Research and Development, PE Biosystems, Framingham, Massachusetts Ramon Eritja: Instituto de Biologia Molecular de Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona, Spain Gregg B. Fields: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton Pilar Forns: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton Carlos Garcia-Echeverria: Oncology Research, Novartis Pharma Inc., Basel, Switzerland Ernest Giralt: Department of Organic Chemistry, University of Barcelona, Spain Gilles Guichard: Laboratory for Immunological Chemistry, UPR 9021 CNRS, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France Richard A. Houghten: Department of Chemistry, Torrey Pines Institute for Molecular Studies, San Diego, California Steven A. Kates: Department of Chemistry, Consensus Pharmaceuticals, Inc., Medford, Massachusetts Ashok Khatri: Endocrine Unit/Medicine, Massachusetts General Hospital, Boston Gilles A. Lajoie: Department of Chemistry, University of Waterloo, Ontario, Canada Paul Lloyd-Williams: Department of Organic Chemistry, University of Barcelona, Spain John S. McMurray: Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston Katalin Folkl Medzihradszky: Department of Pharmaceutical Chemistry, University of California San Francisco Adel Nefzi: Department of Chemistry, Torrey Pines Institute for Molecular Studies, San Diego, California Ernesto Nicolas: Department of Organic Chemistry, University of Barcelona, Spain Andrew Organ: Computational and Structural Sciences, SmithKline Beecham Pharmaceuticals, Essex, England John M. Ostresh: Department of Chemistry, Torrey Pines Institute for Molecular Studies, San Diego, California Jacques Y. Roberge: Early Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey Paolo Rovero: Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano, Italy John D. Wade: Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia Susan T. Weintraub: Department of Biochemistry, The University of Texas Health Science Center at San Antonio Francine Wincott: Department of Oligonucleotide Chemistry, Ribozyme Pharmaceuticals, Inc., Boulder, Colorado T. Scott Yokum: Department of Chemistry, University of Minnesota, Minneapolis