Sourcebook of Models for Biomedical Research

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ISBN: 9781588299338 | 1588299333
Cover: Hardcover
Copyright: 12/11/2007

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The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Preface	p. v
Contributors	p. xi
List of Color Plates	p. xv
Introduction
Animal Models for Human Diseases: An Overview	p. 3
Selection of Biomedical Animal Models	p. 9
Improved Models for Animal Research	p. 17
General Considerations
The Ethical Basis for Animal Use in Research	p. 27
Bibliographic Searching Tools on Disease Models to Locate Alternatives for Animals in Research: A Website Companion	p. 35
NIH Policies on Sharing of Model organisms and Related Research Resources	p. 43
Databases for Biomedical Animal Resources	p. 49
Psychological Enrichment for Animals in Captivity	p. 55
Well-Established Models
Yeast, Worms, Flies, Sea Animals, and Birds
Integrated Network Modeling of Molecular and Genetic Interactions	p. 67
The Sponge as a Model of Cellular Recognition	p. 75
Sea Urchin Embryo: A Model System for Analyzing Cellular Activities During Early Development	p. 85
Caenorhabditis elegans Models of Human Neurodegenerative Diseases: A Powerful Tool to Identify Molecular Mechanisms and Novel Therapeutic Targets	p. 91
Zebrafish as a Model for Development	p. 103
Zebrafish as a Model for Studying Adult Effects of Challenges to the Embryonic Nervous System	p. 113
Modeling Cognitive and Neurodegenerative Disorders in Drosophila melanogaster	p. 121
Biomedical Research with Honey Bees	p. 129
Establishing and Maintaining a Xenopus laevis Colony for Research Laboratories	p. 139
The Chicken as a Model Organism	p. 161
Rodents
Rat Knockout and Mutant Models	p. 171
Rodent Genetics, Models, and Genotyping Methods	p. 179
The House Mouse in Biomedical Research	p. 187
Mouse Model for Alzheimer's Disease	p. 191
Guinea Pigs as Models for Human Cholesterol and Lipoprotein Metabolism	p. 201
Reliability of Rodent Models	p. 213
Cats, Dogs, and Pigs
The Domestic Cat, Felis catus, as a Model of Hereditary and Infectious Disease	p. 221
Swine in Biomedical Research	p. 233
The Minipig as an Animal Model in Biomedical Stem Cell Research	p. 241
Nonhuman Primates
The Nonhuman Primate as a Model for Biomedical Research	p. 251
Primates as Models of Behavior in Biomedical Research	p. 259
Primate Models for Understanding Brain Mechanisms of Cognitive Behavior	p. 267
Models for Specific Purposes
Visual and Auditory Disease
Animal Models for Eye Diseases and Therapeutics	p. 279
Animal Models of Noise-Induced Hearing Loss	p. 289
Trauma, Pain, and Neurology
Human and Animal Models for the Study of Muscle Pain	p. 305
Animal Models of Parkinson's Disease	p. 313
Transgenic Animal Models of Neurodegenerative Diseases	p. 323
Animal Models of Nociception and Pain	p. 333
Nonmammalian Models for the Study of Pain	p. 341
Models of Behavior
Cardiovascular
Animal Models of Vascular Development and Endothelial Cell Biology	p. 355
Models of Behavior: Cardiovascular	p. 361
Animal Models for Atherosclerosis, Restenosis, and Endovascular Aneurysm Repair	p. 369
Transgenic Mouse Models of HIV-1/AIDS and Cardiac Performance	p. 385
Reproduction
Primate Models for the Assisted Reproductive Technologies and Embryonic Stem Cell Biology	p. 397
Rat Models of Polycystic Ovary Syndrome	p. 405
Murine Models for Reproduction	p. 411
Pig Model to Study Dynamics of Steroids During Ovarian Follicular Growth and Maturation	p. 425
Drug Development and Research Models
Molecular Genetic Approach to Identify Inhibitors of Signal Transduction Pathways: Fission Yeast as a Model System for Drug Discovery	p. 439
Yeast as a Model System to Study DNA Damage and DNA Repair	p. 445
Physiology
Human Models of Space Physiology	p. 457
Developmental Space Biology of Mammals: Concepts and Methods of Study	p. 465
A Practical Approach to Animal Models of Sepsis	p. 473
Animal Models in Functional Magnetic Resonance Imaging	p. 483
Animal Models in Aging Research: A Critical Examination	p. 499
Genetics
Gene Targeting in Human Somatic Cells	p. 509
Animal Models for Investigating the Causes and Mechanisms of Mammalian Germ Cell Aneuploidy	p. 527
Genetic Models of Alzheimer's Disease	p. 539
Immunology and Virology
Rat Models of Experimental Autoimmune Encephalomyelitis	p. 547
Animal Models in Virology	p. 557
Nonhuman Primate Models for AIDS	p. 565
Models of other Human Diseases
Use of Congenic Mouse Strains for Candidate Disease Gene Identification in Complex Traits	p. 575
Animal Models of Sudden Infant Death Syndrome	p. 583
Animal Models of Posttraumatic Stress Disorder	p. 591
Animal Models for Studying Fetal Alcohol Syndrome, Alcohol-Related Birth Defects, and Alcohol-Related Neurodevelopmental Disorder	p. 603
Modeling Drug and Alcohol Abuse: Experimental Examples of the Utility of Zebrafish	p. 615
Mouse Models for Experimental Cancer Therapy	p. 623
Rat Models of Skin Wound Healing	p. 631
Animal Models of Prostate Cancer	p. 639
Animal Models of Diabetes	p. 651
Animal Models of Kidney Diseases	p. 657
Animal Models of Multiple Sclerosis	p. 665
Canine and Feline Models for Cancer	p. 677
Obese Mouse Models	p. 683
Study of Polycystic Kidney Disease in the Nematode Caenorhabditis elegans	p. 703
Animal Models of Myelofibrosis	p. 713
Animal Models for Bone Tissue Engineering Purposes	p. 725
Other Tools
Markov Processes for Biomedical Data Analysis	p. 739
Software Tools for Modeling Biomedical Systems	p. 747
Developing Websites for Biomedical Research and Training	p. 753
Building Virtual Research Communities Using Web Technology	p. 759
Index	p. 763
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