Strategies for Reducing Drug and Chemical Residues in Food Animals International Approaches to Residue Avoidance, Management, and Testing

• Focuses attention on drug and chemical residues in edible animal products
• Covers novel computational, statistical, and mathematical strategies for dealing with chemical exposures in food animals
• Details major drug classes used in food animal production and their residue risks
• Highlights efforts at harmonizing and the differences among areas like US, EU, Canada, Australia, South America, China, and Asia, where the issue of chemical exposures has significant impact on livestock products
• Ties veterinary clinical practice and the use of these drugs in food animals with regulatory standards and mitigation practices

Ronald Baynes is a Professor of Pharmacology and Director of the Center of Chemical Toxicology Research and Pharmacokinetics at the College of Veterinary Medicine at North Carolina State University and Fellow, American Academy of Veterinary Pharmacology and Therapeutics He has consulted for the National Institute of Environmental Health Sciences, the US Environmental and Protection Agency, and National Institute of Occupational Safety and Health on chemical exposure-related topics.

Jim Riviere is The MacDonald Chair in Veterinary Medicine and University Distinguished Professor at Kansas State University. He is an elected member of the Institute of Medicine of the National Academies, serves on its Food and Nutrition Board, and is a fellow of the Academy of Toxicological Sciences.

Preface vii

Contributors ix

1 Importance of Veterinary Drug Residues 1
Ronald E. Baynes and Jim E. Riviere

2 Pharmacokinetic Principles for Understanding Drug Depletion as a Basis for Determination of Withdrawal Periods for Animal Drugs 9
Sanja Modric

3 Evaluation of Drug Residue Depletion in the Edible Products of Food-Producing Animals for Establishing Withdrawal Periods and Milk Discard Times 35
Dong Yan

4 Establishing Maximum Residue Limits in Europe 49
Kornelia Grein and Isaura Duarte

5 Methods to Derive Withdrawal Periods in the European Union 65
G. Johan Schefferlie and Stefan Scheid

6 Population Pharmacokinetic Modeling to Predict Withdrawal Times 81
Sharon E. Mason

7 Physiologically Based Pharmacokinetic Modeling 95
Jennifer Buur

8 Residue Avoidance in Beef Cattle Production Systems 115
Virginia Fajt and Dee Griffin

9 Residue Avoidance in Dairy Cattle Production Systems 137
Geof Smith

10 Residue Avoidance in Aquaculture Production Systems 161
Renate Reimschuessel

11 Residue Avoidance in Small Ruminant Production Systems 193
Kevin Anderson and Reha Azizoglu

12 Residue Avoidance in Swine Production Systems 221
Ronald E. Baynes and Glen Almond

13 Confirmatory Methods for Veterinary Drugs and Chemical Contaminants in Livestock Commodities 233
Hui Li

14 The Food Animal Residue Avoidance Databank: An Example of Risk Management of Veterinary Drug Residues 289
Thomas W. Vickroy, Ronald E. Baynes, Lisa Tell and Jim E. Riviere

15 Risk Management of Chemical Contaminants in Livestock 303
Ronald E. Baynes and Jim E. Riviere

Index 313

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.