Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels

, by Gribkoff, Valentin K.; Kaczmarek, Leonard K.

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ISBN: 9780471930136 | 047193013X
Cover: Hardcover
Copyright: 2/3/2009

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This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

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Preface	p. ix
Contributors	p. xi
Neuronal Voltage-Gated Ion Channel Functions	p. 1
Neuronal L-Type Voltage-Gated Calcium Channels	p. 3
Voltage-Gated N-Type and T-Type Calcium Channels and Excitability Disorders	p. 35
Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of Pain	p. 67
The Rule of Ion Channels in the Etiology and Development of Gliomas	p. 105
Shaker Family Kv1 Voltage-Gated Potassium Channels in Mammalian Brain Neurons	p. 127
Unique Mitochondrial Ion Channels: Roles in Synaptic Transmission and Programmed Cell Death	p. 155
Regulation of Neuronal Excitability by the Sodium-Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2)	p. 193
Modulatory Mechanisms and Influences on Neuronal Voltage-Gated Ion Channel Function	p. 217
Alternative Splicing of Neuronal Cav2 Calcium Channels	p. 219
Effect of Hypoxia/Ischemia on Voltage-Dependent Channels	p. 251
In Vivo Roles of Ion Channel Regulatory Protein Complexes in Neuronal Physiology and Behavior	p. 279
Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons	p. 291
BK Channels: Regulation of Expression and Physiological Impact	p. 317
Structural Basis for Auxiliary KChIP Modulation of Kv4 Channels	p. 343
Drug Discovery Targets and Technology	p. 363
Sodium Channel Blockers for the Treatment of Chronic Pain	p. 365
Neuronal K_v7 Potassium Channels as Emerging Targets for the Treatment of Pain	p. 393
Small-Molecule Modulators of Large-Conductance, Calcium-Activated (BK) Channels	p. 423
High-Throughput Screening Technologies in Ion Channel Drug Discovery	p. 443
Index	p. 467
Table of Contents provided by Ingram. All Rights Reserved.

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Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels

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