Studies in Natural Products Chemistry

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ISBN: 9780444538369 | 0444538364
Cover: Hardcover
Copyright: 7/13/2012

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Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 36 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable source for researchers and engineers working in natural product, and medicinal chemistry. Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field A valuable source for researchers and engineers working in natural product and medicinal chemistry

Contributors	p. ix
Preface	p. xi
Volumes in Series	p. xiii
Isolation, Biological Activities, and Synthesis of the Natural Casuarines	p. 1
Introduction	p. 1
Glycosidase Inhibitory Activities of the Natural Casuarines	p. 5
Synthesis of the Natural Casuarines	p. 6
Conclusions	p. 22
Acknowledgments	p. 23
References	p. 24
The Acylpolyamines from Spider Venoms	p. 27
Introduction	p. 27
Spider Diversity and the Composition of Their Venoms	p. 28
The Acylpolyamine Toxins: Structural Elucidation and Chemical Diversity	p. 28
Biological Activities	p. 33
The Chemical Synthesis of Acylpolyamine Toxins	p. 36
Concluding Remarks	p. 37
Acknowledgments	p. 39
References	p. 39
Deep-Sea Hydrothermal Vents as a New Source of Drug Discovery	p. 43
Introduction	p. 43
Deep-Sea Hydrothermal Vents as a Hot Spot for Bioactive Marine Natural Products Discovery	p. 44
Main Mechanism of Apoptosis Induction and New Approach in Research and Treatment of Cancer	p. 47
Ammonificins A and B, Hydroxyethylamine Chroman Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, T. ammonificans	p. 49
Bathymodiolamides A and B, Ceramide Derivatives from a Deep-Sea Hydrothermal Vent Invertebrate Mussel, B. thermophilus	p. 54
Induction of Apoptosis by Diterpenes from the Soft Coral Xenia elongata	p. 58
Conclusion	p. 62
Acknowledgments	p. 62
References	p. 63
Marine Cyanobacteria: A Treasure Trove of Bioactive Secondary Metabolites for Drug Discovery	p. 67
Introduction	p. 67
Linear Lipopeptides/Peptides	p. 68
Cyclic Depsipeptides/Peptides	p. 82
Acknowledgments	p. 104
References	p. 106
Novel Bioactive Peptides from Cyanobacteria: Functional, Biochemical, and Biomedical Significance	p. 111
Introduction	p. 111
Anticancer Peptides	p. 112
Antiviral Peptides	p. 141
Antifungal Peptides	p. 143
Antibacterial Peptides	p. 147
Anti-Inflammatory Peptides	p. 147
Molluscicidal Peptides	p. 149
Conclusions	p. 153
Acknowledgment	p. 154
References	p. 155
Bioactive Marine Prenylated Quinones/Quinols	p. 163
Introduction	p. 163
Monoprenyls Group	p. 164
Monoterpenoids Group	p. 165
Sesquiterpenoids Group	p. 168
Diterpenoids Group	p. 194
Sesterterpenoids Group	p. 202
Triterpenoids Group	p. 204
Heptaprenyls Group	p. 207
Octaprenyls Group	p. 208
Nonaprenyls Group	p. 209
References	p. 211
Chlorosulfolipids	p. 219
Introduction	p. 219
Chlorosulfolipids from O. danica	p. 221
Chlorosulfolipids from P. malhamensis	p. 237
Chlorosulfolipids from Adriatic Mussels	p. 240
Conclusions	p. 244
References	p. 245
Diversity and Ecological Significance of Fungal Endophyte Natural Products	p. 249
Introduction	p. 249
What are Endophytic Fungi?	p. 250
Working with Endophytic Fungi: Principles of Isolation and Cultivation	p. 253
Structures of Endophytic Natural Products with Regard of their Ecological Role	p. 255
The Production of Plant-Derived Compounds by Endophytic Fungi	p. 282
The Regulation of Secondary Metabolite Biosynthesis in Endophytic Fungi	p. 285
Conclusion	p. 286
References	p. 287
Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms	p. 297
Introduction	p. 297
Chemistry and Classification	p. 298
Anti-Inflammatory and Analgesic Flavonoids and Their Mechanisms	p. 298
Development of Oral Formulations Containing Flavonoids	p. 312
Development of Topical Formulations Containing Flavonoids	p. 317
Conclusions	p. 322
Acknowledgments	p. 323
References	p. 324
Antileishmanial Natural Products from Plants	p. 331
Introduction	p. 331
References	p. 377
Index	p. 383
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