Symposium 78: Immunity and Tolerance

The 78th Symposium volume covers many aspects of the immune system including the genetics, biochemistry, molecular and cell biology, and developmental biology of immune responses. New approaches intended to harness the immune system to treat disease, particularly cancer, are also discussed.

The volume's broad synthesis of the current knowledge about immunity and tolerance includes molecular mechanisms of B and T lymphocyte development from the single cell to the entire organism and from single genes to genomes. There is a focus on the development and function of innate cells, including myeloid cells, natural killer cells, and a more recently defined innate lymphoid cell that resembles a T cell. Transcriptional regulation of key immune pathways in innate and adaptive cells of the immune system are covered. The effect of metabolic pathways on immune responses is discussed and, conversely, how immune cells may affect cell and tissue physiology outside of the immune response. Other topics include the protective effect of commensal bacteria, the diverse immune mechanisms underlying chronic infection or immune control in HIV and tuberculosis, and insights into autoimmune diseases that may lead to new clinical therapies. Specific coverage includes:



· Stem cells and cell fate decisions


· Regulation of immune cell development


· Antigen receptor gene assembly and modification


· Signal transduction


· Regulation of lymphocyte function


· Innate immune response and inflammation


· Adaptive immunity


· Mucosal immunity


· Organ specific immunity


· Immune regulation and tolerance


· Autoimmunity and allergy


· Immunity and cancer


· Pathogen-immune system interactions


· Vaccine development


· Novel strategies to engineer/harness immunity

(preliminary)

Symposium Participants
Foreword

1. TET proteins and 5-methylcytosine oxidation in the immune system
Ageliki Tsagarato and Anjana Rao

2. Immunology Taught by Human Genetics
Jean-Laurent Casanova, Laurent Abel, and Lluis Quintana-Murci

3. Control of antigen receptor diversity through spatial regulation of V(D)J recombination
Anja Ebert, Jasna Medvedovic, Hiromi Tagoh, Tanja Schwickert, and Meinrad Busslinger

4. Establishment and Maintenance of B Lymphocyte Identity
Rudolf Grosschedl

5. Transcriptional Establishment of Cell-type Identity: Dynamics and Causal
Mechanisms of T-cell Lineage Commitment
Ellen V. Rothenberg, Ameya Champhekar, Sagar Damle, Marissa Morales
Del Real, Hao Yuan Kueh, Long Li, and Mary A. Yui

6. Regnase-1, A Ribonuclease Involved in the Regulation of Immune Response
Shizuo Akira

7. The Epigenetics of Early Lymphocyte Development
Cornelius Murre

8. Regulation of transcriptional cascades associated with inflammatory
and innate immune responses
Steve Smale

9. Tolerization of inflammatory gene expression
John J. Seeley and Sankar Ghosh

10. The 'Histone Mimicry" by Pathogens
Uwe Schaefer, Jessica S.Y. Ho, Rab K. Prinjha, and Alexander Tarakhovsky

11. Pro-active cell death aversion by Mycobacterium tuberculosis mediates
evasion of adaptive immune responses
William Jacobs

12. Systems Approach to Understand the Immune Response in Tuberculosis:
An Iterative Process between Mouse Models and Human Disease
Anne O'Garra

13. The zebrafish guide to tuberculosis immunity and treatment
Lalita Ramakrishnan

14. Microbiota-Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity
Randy S. Longman, Yi Yang, Gretchen E. Diehl, Sangwon V. Kim,
and Dan R. Littman

15. The Promised Land of Human Immunology
Laura F. Su, Arnold Han, Helen M. McGuire, David Furman, Evan W. Newell,
and Mark M. Davis

16. Dissection of signaling in inflammation: Three Novel Inflammatory Regulators
Thorsten Berger, Mary E. Saunders and Tak W. Mak

17. Tissue-Resident Natural Killer Cells
Wayne M. Yokoyama, Dorothy K. Sojka, Hui Peng, and Zhigang Tian

18. Myb-independent Macrophages: A Family of Cells that Develops with Their
Tissue of Residence and Is Involved in Its Homeostasis
Elisa Gomez Perdiguero and Frederic Geissmann

19. The molecular choreography of IRF4 and IRF8 with immune system partners
Harinder Singh

20. The IRF Family Transcription Factors at the Interface of Innate and Adaptive
Immune Responses
Hiroaki Ikushima, Hideo Negishi, and Tadatsugu Taniguchi

21. Transcriptional Control of Regulatory T Cell Differentiation
Joris van der Veeken, Aaron Arvey, and Alexander Rudensky

22. miR-181 and Metabolic Regulation in the Immune System
Adam Williams, Jorge Henao-Mejia, Christian C.D. Harman,
and Richard A. Flavell

23. Encoding Immunological Memory in the Initiation of B Cell Receptor Signaling
Susan K. Pierce and Wanli Liu

24. PD-1 directed immunotherapy for enhancing T cell function
Koichi Araki, Ben Youngblood, and Rafi Ahmed

25. Immune Surveillance of Unhealthy Cells by Natural Killer Cells
Alexandre Iannello and David H. Raulet

26. Studying Epstein-Barr-Virus Pathologies and Immune Surveillance by
Reconstructing EBV Infection in Mice
Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich,
Marc Schmidt-Supprian, Thomas Sommermann, and Klaus Rajewsky

27. IL-1b Strikingly Enhances Antigen-Driven CD4 and CD8 T Cell Responses
S. Zani Ben-Sasson, K. Wang, J. Cohen, and William E. Paul

28. A Modified Model of T Cell Differentiation Based upon mTOR Activity
and Metabolism
Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi,
and Adam T. Waickman

29. Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk
and the phosphatase CD45
Ying Xim Tan, Julie Zikherman, and Arthur Weiss

30. Pathogen-Sensing, Regulatory T Cells and Responsiveness-Tuning Collectively
Regulate Foreign- and Self-Antigen Mediated T-Cell Responses
William E. Paul, Joshua Milner, and Zvi Grossman