Synthetic Approaches to Nonaromatic Nitrogen Heterocycles, 2 Volume Set

A comprehensive overview of synthetic strategies for nonaromatic nitrogen heterocycles

Nitrogen heterocycles are extremely widely distributed in nature, as well as in synthetic substances found in pharmaceuticals, agrochemicals, and materials chemistry. With new structures and medicines that include these structures emerging yearly, and a vast new journal literature to describe them, anyone who wants to be effective in R&D needs to easily access a synthesis of the latest research.

This state-of-the-art survey explores recent developments in the most widely used reactions, as well as completely new ones.

• Highlights the major modern synthetic methods known to obtain nonaromatic nitrogen heterocycles, and their practical applications
• Topics include enantioselective synthesis and catalysis, photocatalysis, biocatalysis, microwave-assisted synthesis, reactions of oximes and nitrones, and ionic liquids
• Discusses how to synthesize rings of specific sizes
• Covers sustainable synthetic approaches for obtaining salts

Whether you are using nonaromatic nitrogen compounds as an academic researcher, a synthetic chemist in industry, or an advanced student, this book is an essential, up-to-date resource to support your work.

Ana Maria M. M. Faisca Phillips Researcher, Coordination Chemistry and Catalysis Group, Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.

List of Contributors

Preface

List of Common Abbreviations

Chapter 1. Introduction

Chapter 2. Recent Advances in the Synthesis of Aziridines

Chapter 3. Synthesis of Four-Membered Aza-Heterocycles Through Catalytic [2+2] Cycloaddition Reactions Assisted by Metal Complexes

Chapter 4. Therapeutic Potentials of β-Lactam: A Scaffold for New Drug Development

Chapter 5. Progress in the Synthesis Of Chiral Nitrogen Heterocycles Mainly by Asymmetric [3+2] Cycloadditions

Chapter 6. Synthesis of Five-Membered N-Heterocycles by Enantioselective, Metal-Catalyzed, Intramolecular, Hydroamination of Alkenes

Chapter 7.  Recent Advances in the Synthesis of Isoxazolidines

Chapter 8. Recent Advances in the Stereoselective Synthesis of Pyrrolizidin-3-ones

Chapter 9. Synthesis of Spirooxindoles by Multicomponent Reactions

Chapter 10. Modern Catalytic, Enantioselective Approaches to Piperidines

Chapter 11. Organocatalytic Enantioselective Dearomatization Reactions for the Synthesis of Nitrogen Heterocycles

Chapter 12. Synthesis of Dihydroquinolines in the XXI Century

Chapter 13. Asymmetric Aza-Diels–Alder Reaction–Application in the Synthesis of Natural Products

Chapter 14. Synthesis of Saturated Nitrogen-Containing Heterocycles Through [5+2] Cycloadditions

Chapter 15. Modern Methods for the Synthesis of 1,4-Oxazepanes and Their Oxo-Derivatives

Chapter 16. Non-Aromatic Nitrogen Heterocycles Derived from Metal-Involving Reactions of Oximes

Chapter 17. Metal-Catalyzed and Metal-Mediated Reactions of Nitrones Leading to Non-Aromatic Nitrogen Heterocyclic Systems

Chapter 18. Recent Developments in the Chemical Synthesis of Amaryllidaceae Alkaloids

Chapter 19. Enantioselective Synthesis of Nitrogen Heterocycles by Radical Reactions

Chapter 20.  Recent Applications of Microwave-assisted Cyclizations Promoted by Polyphosphoric Acid Esters to the Synthesis of Nitrogen Heterocycles

Chapter 21.  Biocatalysis Towards the Synthesis of Chiral Amines

Chapter 22.  Photocatalytic Synthesis of Nitrogen-Containing Heterocycles

Chapter 23.  Sustainable Synthetic Approaches for Nitrogen-Containing Heterocyclic Salts

Chapter 24.  Noncovalent Interactions in N-Heterocyclic Chemistry: Synthesis, Catalysis and Design of Materials

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