Synthetic Polymers for Biotechnology and Medicine

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ISBN: 9781587060274 | 1587060272
Cover: Hardcover
Copyright: 12/1/2002

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Swiss Federal Institute of Technology, Lausanne, Switzerland. Comprehensive text on the use of synthetic polymers in the life sciences. Topics include the delivery of biologicals using synthetic polymers, bioseparation, and the use of hybrid molecules. Hardcover, softcover not yet available. DNLM: Polymers.

Preface

vii

Cell Encapsulation: Generalities, Methods, Applications and Bioartificial Pancreas Case Study

(18)

Gabriela Grigorescu

David Hunkeler

Introduction

(3)

Immunoisolation

(1)

Cell Delivery

(2)

Microencapsulation

(1)

Bioartificial Organs

(3)

Case Study: Insulin Production Systems

(3)

Socio-Political Considerations

(1)

Conslusions

(5)

Synthetic and Semisynthetic Polymers as Vehicles for In Vitro Gene Delivery into Cultured Mammalian Cells

(21)

Martin Jordan

Introduction: Impact of Molecular Biology

(1)

Areas in Need of Efficient Gene Delivery

(1)

The DNA Molecule

(1)

Barriers to Efficient Gene Transfer

(14)

Conclusions

(1)

Definitions

(1)

Structures of Frequently Used Molecules

(3)

Affinity Precipitation: Stimulus-Responsive Polymers for Bioseparation

(18)

Ruth Freitag

Introduction

(1)

The Role of Affinity Separations in Product Isolation

(2)

The Principle and Application of Affinity Precipitation

(5)

Smart Polymers for Affinity Precipitation

(2)

Thermosensitive AML

(3)

Introduction of the Affinity Mediator

(1)

Conclusions and Outlook

(4)

Synthetic Displacers for Preparative Biochromatography

(29)

Ruth Freitag

Christine Wandrey

Introduction

(1)

The Principle of Displacement Chromatography

(5)

Displacers for Biochromatography

(9)

Polyelectrolytes

(4)

Steric Mass Action Model

(5)

Systematic Displacer Design, Some Theoretical Considerations

(2)

Conclusions

(3)

Membrane Adsorbers for Decontamination and Leukocyte Removal

(29)

Galya Tishchenko

Miroslav Bleha

Introduction

(1)

Evaluation of the Adsorbing Efficiency of Interactive Membranes

(2)

Membranes for Depyrogenation (Endotoxin Removal)

(18)

Membranes for Removal of Bacteria and Viruses from Aqueous Solution

108

(2)

Membranes for Removal of Leukocytes from Blood Products

110

(2)

Conclusions

112

(4)

Stimulus Responsive Surfaces: Possible Implications for Biochromatography, Cell Detachment and Drug Delivery

116

(18)

Igor Yu Galaev

Bo Mattiasson

Stimulus-Responsive Polymers

117

(2)

Polymer-Grafted Surfaces

119

(1)

Temperature-Responsive Chromatography

120

(2)

Cell Detachment from Polymer-Grafted Surfaces

122

(3)

Controlling Porosity via Smart Polymers---The ``Chemical Valve''

125

(2)

Polymer-Carrying Liposomes for Triggered Release/Drug Delivery

127

(2)

Conclusions

129

(5)

Molecularly Imprinted Polymers: A New Dimension in Analytical Bioseparation

134

(29)

Oliver Bruggemann

Introduction

134

(1)

The Principle of Molecular Imprinting

134

(7)

MIP for Bioseparation

141

(8)

Binding Assays Using MIP

149

(2)

Sensor Technology

151

(1)

MIP to Assist Chemical Synthesis

151

(3)

Conclusions

154

(9)

Index

163

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Synthetic Polymers for Biotechnology and Medicine

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Table of Contents

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