Systems Biology

Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecendented in its combination of biology with a great many other sicences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies. * Answers the question of what distinguishes the living from the non-living * An in-depth look to a vigorous and expanding discipline, from molecule to system * Explores the region between individual components and the system

List of Contributors	p. vii
Contributor Biographies	p. ix
Preface	p. xvii
Introduction	p. 1
Towards philosophical foundations of Systems Biology: introduction	p. 3
Research programs of Systems Biology	p. 21
The methodologies of systems biology	p. 23
Methodology is Philosophy	p. 71
How can we understand metabolism?	p. 87
On building reliable pictures with unreliable data: An evolutionary and developmental coda for the new systems biology?	p. 103
Theory and models	p. 121
Mechanism and mechanical explanation in systems biology	p. 123
Theories, models, and equations in systems biology	p. 145
All models are wrong...some more than others	p. 163
Data without models merging with models without data	p. 181
Organization in biological systems	p. 215
The biochemical factory that autonomously fabricates itself: A systems biological view of the living cell	p. 217
A systemic approach to the origin of biological organization	p. 243
Biological mechanisms: organized to maintain autonomy	p. 269
The disappearance of function from 'self-organizing systems'	p. 303
Conclusion	p. 319
Afterthoughts as foundations for systems biology	p. 321
Subject Index	p. 337
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