A Textbook of Modern Toxicology
, by Hodgson, Ernest
- ISBN: 9780470462065 | 047046206X
- Cover: Hardcover
- Copyright: 6/21/2010
Toxicology is a multi-faceted field that requires a keen analytical eye. A Textbook of Modern Toxicology is a unique resource that provides both students and practitioners with an insightful overview of this discipline. This Fourth Edition adds chapters on new approaches to toxicology along with end-of-chapter questions and a solutions manual for academic adopters. Continuing its legacy as a valuable learning tool, this expert text will find a prominent place on the bookshelf of anyone studying this science.
ERNEST HODGSON, PhD, is Distinguished Professor Emeritus of Toxicology at North Carolina State University. In addition to the previous editions of A Textbook of Modern Toxicology, he coedited Molecular and Biochemical Toxicology, Fourth Edition (Wiley) and its prior editions. Dr. Hodgson is the Editor of the Journal of Biochemical and Molecular Toxicology.
| Introduction | |
| Introduction | |
| Definition and Scope | |
| Relationship to Other Sciences | |
| A Brief History of Toxicology | |
| Dose-Response Relationships | |
| Sources of Toxic Compounds | |
| Movement of Toxicants in the Environment | |
| Suggested Reading | |
| Sample Questions | |
| Introduction to Biochemical and Molecular Methods in Toxicology | |
| Introduction | |
| Cell Culture Techniques | |
| Molecular Techniques | |
| Immunochemical Techniques | |
| Proteomics | |
| Metabolomics | |
| Bioinformatics | |
| Summary and Conclusions | |
| Suggested Reading | |
| Sample Questions | |
| Classes of Toxicants | |
| Exposure Classes, Toxicants in Air, Water, Soil, Domestic and Occupational Settings | |
| Air Pollutants | |
| Water and Soil Pollutants | |
| Occupational Toxicants | |
| Suggested Reading | |
| Sample Questions | |
| Classes of Toxicants: Use Classes | |
| Introduction | |
| Metals | |
| Agricultural Chemicals (Pesticides) | |
| Food Additives and Contaminants | |
| Toxins | |
| Solvents | |
| Therapeutic Drugs | |
| Drugs of Abuse | |
| Combustion Products | |
| Cosmetics | |
| Suggested Reading | |
| Sample Questions | |
| Toxicant Processing In Vivo | |
| Absorption and Distribution of Toxicants | |
| Introduction | |
| Cell Membranes | |
| Mechanisms of Transport | |
| Physicochemical Properties Relevant to Diffusion | |
| Routes of Absorption | |
| Toxicant Distribution | |
| Toxicokinetics | |
| Suggested Reading | |
| Sample Questions | |
| Metabolism of Toxicants | |
| Introduction | |
| Phase I Reactions | |
| Phase II Reactions | |
| Suggested Reading | |
| Sample Questions | |
| Reactive Metabolites | |
| Introduction | |
| Activation Enzymes | |
| Nature and Stability of Reactive Metabolites | |
| Fate of Reactive Metabolites | |
| Factors Affecting Toxicity of Reactive Metabolites | |
| Reactive Oxygen Species | |
| Examples of Activating Reactions | |
| Summary and Conclusions | |
| Suggested Reading | |
| Sample Questions | |
| Chemical and Physiological Influences on Xenobiotic Metabolism | |
| Introduction | |
| Nutritional Effects | |
| Physiological Effects | |
| Comparative and Genetic Effects | |
| Chemical Effects | |
| Environmental Effects | |
| Summary and Conclusions | |
| Suggested Reading | |
| Sample Questions | |
| Elimination of Toxicants | |
| Introduction | |
| Transport | |
| Renal Elimination | |
| Hepatic Elimination | |
| Respiratory Elimination | |
| Conclusion | |
| Suggested Reading | |
| Sample Questions | |
| Toxic Action | |
| Acute Toxicity | |
| Introduction | |
| Acute Exposure and Effect | |
| Dose-Response Relationships | |
| Non-Conventional Dose-Response Relationships | |
| Alternative Methods | |
| Mechanisms of Acute Toxicity | |
| Suggested Reading | |
| Sample Questions | |
| Chemical Carcinogenesis | |
| DNA Damage and Mutagenesis | |
| General Aspects of Cancer | |
| Human Cancer | |
| Classes of Agents That Are Associated with Carcinogenesis | |
| General Aspects of Chemical Carcinogenesis | |
| Oncogenes | |
| Tumor Suppressor Genes | |
| Suggested Reading | |
| Sample Questions | |
| Teratogenesis | |
| Introduction | |
| Overview of Embryonic Development | |
| Principles of Teratogenesis | |
| Mechanisms of Teratogenesis | |
| Future Considerations | |
| Suggested Reading | |
| Sample Questions | |
| Organ Toxicity | |
| Hepatotoxicity | |
| Introduction | |
| Susceptibility of the Liver | |
| Types of Liver Injury | |
| Mechanisms of Hepatotoxicity | |
| Examples of Hepatotoxicants | |
| Metabolic Activation of Hepatotoxicants | |
| Suggested Reading | |
| Sample Questions | |
| Nephrotoxicity | |
| Introduction | |
| Factors Contributing to Nephrotoxicity | |
| Examples of Nephrotoxicants | |
| Summary | |
| Suggested Reading | |
| Sample Questions | |
| Toxicology of the Nervous System | |
| Introduction | |
| The Nervous System | |
| Toxicant Effects on the Nervous System | |
| Neurotoxicity Testing | |
| Summary | |
| Suggested Reading | |
| Sample Questions | |
| Reproductive System | |
| Introduction | |
| The-Hypothalamic-Pituitary-Gonadal Axis | |
| Male Reproductive Physiology | |
| Disruption of Male Reproduction by Toxicants | |
| Female Reproductive Physiology | |
| Disruption of Female Reproduction by Toxicants | |
| Summary | |
| Suggested Reading | |
| Sample Questions | |
| Endocrine System | |
| Introduction | |
| Endocrine System | |
| Endocrine Disruption | |
| Incidents of Endocrine Toxicity | |
| Conclusion | |
| Suggested Reading | |
| Sample Questions | |
| Respiratory Toxicity | |
| Introduction | |
| Anatomy and Function of the Respiratory Tract | |
| Toxicant-Induced Lung Injury, Remodeling and Repair | |
| Occupational and Environmental Lung Diseases | |
| Suggested Reading | |
| Sample Questions | |
| Immunotoxicity | |
| Introduction | |
| The Immune System | |
| Immune Suppression | |
| Classification of Immune-Mediated Injury (Hypersensitivity) | |
| Effects of Chemicals on Allergic Disease | |
| Other Issues: Autoimmunity, and the Developing Immune System | |
| Suggested Reading | |
| Sample Questions | |
| Applied Toxicology | |
| Toxicity Testing | |
| Introduction | |
| Experimental Administration of Toxicants | |
| Chemical and Physical Properties | |
| Exposure and Environmental Fate | |
| In Vivo Tests | |
| In Vitro and Other Short-Term Tests | |
| Ecological Effects | |
| Risk Analysis | |
| The Future of Toxicity Testing | |
| Suggested Reading | |
| Sample Questions | |
| Forensic and Clinical Toxicology | |
| Introduction | |
| Forensic Toxicology | |
| Clinical Toxicology | |
| Analytical Methods in Forensic and Clinical Toxicology | |
| Suggested Reading | |
| Sample Questions | |
| Prevention of Toxicity | |
| Introduction | |
| Legislation and Regulation | |
| Prevention in Different Environments | |
| Education | |
| Suggested Reading | |
| Sample Questions | |
| Human Health Risk Assessment | |
| Introduction | |
| Risk Assessment Methods | |
| Non-Cancer Risk Assessment | |
| Cancer Risk Assessment | |
| PBPK Modeling | |
| Suggested Reading | |
| Sample Questions | |
| Environmental Toxicology | |
| Toxicant Analysis | |
| Introduction | |
| Environmental Sample Collection Methods | |
| Analytical Techbiques | |
| Quantification, Quality Assurance and Quality Control | |
| Summary | |
| Suggested Reading | |
| Sample Questions | |
| Basics of Environmental Toxicology | |
| Introduction | |
| Environmental Persistence | |
| Bioaccumulation | |
| Toxicity | |
| Conclusion | |
| Suggested Reading | |
| Sample Questions | |
| Transport and Fate of Toxicants in the Environment | |
| Introduction | |
| Sources of Toxicants to the Environment | |
| Transport Processes | |
| Equilibrium Partitioning | |
| Transformation Processes | |
| Environmental Fate Models | |
| Suggested Reading | |
| Sample Questions | |
| Ecological Risk Assessment | |
| Introduction | |
| Formulating the Problem | |
| Analyzing Exposure and Effects Information | |
| Characterizing Risk | |
| Managing Risk | |
| Suggested Reading | |
| Sample Questions | |
| New Approaches in Toxicology | |
| Perspectives on Informatics in Toxicology | |
| Introduction | |
| Transcriptomics | |
| Annotation Resources | |
| Genome Sequencing, Re-sequencing and Genotyping | |
| Epigenomic Profiling | |
| Computation Toxicology | |
| Informatics Tools in Toxicology | |
| Suggested Reading | |
| Sample Questions | |
| Future Considerations | |
| Introduction | |
| Risk Assessment | |
| Risk Management | |
| Risk Communication | |
| In Vivo Toxicity | |
| In Vitro Toxicity | |
| Molecular and Biochemical Toxicology | |
| Development of Selective Toxicants | |
| Summary and Conclusions | |
| Suggested Reading | |
| Sample Questions | |
| Glossary | |
| Index | |
| Table of Contents provided by Publisher. All Rights Reserved. |
What is included with this book?
The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.
The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.
Please wait while the item is added to your bag...
×
Digital License
You are licensing a digital product for a set duration. Durations are set forth in the product description, with "Lifetime" typically meaning five (5) years of online access and permanent download to a supported device. All licenses are non-transferable.
More details can be found here.