Thiamine: Catalytic Mechanisms in Normal and Disease States

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ISBN: 9780824740627 | 0824740629
Cover: Hardcover
Copyright: 12/11/2003

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Explains the enzymology of thiamine diphosphate enzymes and the biosynthesis of thiamine and its phosphorylated terms. Comprehensively explores the structure-function of thiamine diphosphate multienzyme complexes and biomedical aspects of thiamine diphosphate-dependent enzymes.

Series Introduction

Lester Packer and Enrique Cadenas

iii

Preface

vii

Contributors

Part I: Introduction

1. Chemical Intermediates in Catalysis by Thiamine Diphosphate

(14)

Perry A. Frey

Part II: Biosynthesis of Thiamine and Its Phosphorylated Terms

2. Mechanistic and Structural Studies on Thiamine Biosynthetic Enzymes

(14)

Tadhg P. Begley and Steven E. Ealick

3. Studies on the Structure and Function of Thiamine Pyrophosphokinase

(14)

Jing-Yuan Liu, David E. Timm, Robert A. Harris, and Thomas D. Hurley

4. New Perspectives on the Cellular Role of Thiamine Triphosphate and Thiamine Triphosphatase

(14)

Lucien Bettendorff and Pierre Wins

Part III: Enzymology of Thiamine Diphosphate Enzymes

5. How Thiamine Works in Enzymes: Time-Resolved NMR Snapshots of TDP-Dependent Enzymes in Action

(20)

Kai Tittmann, Ralph Golbik, Kathrin Uhlemann, Ludmila Khailova, Mulchand S. Patel, Frank Jordan, David M. Chipman, Ronald G. Duggleby, Gerhard Hübner, and Gunter Schneider

6. Thiamine-Dependent Enzymes as Catalysts of C-C Bond-Forming Reactions: The Role of "Orphan" Enzymes

(16)

Michael Müller and Georg A. Sprenger

7. Ligand-Induced Conformational Changes in Thiamine Diphosphate-Dependent Enzymes: Comparison Between Crystal and Solution Structures

(20)

Stephan König, Michael Spinka, Erik Fiedler, Georg Wille, Johanna Brauer, Michel H.J. Koch, and Dmitri I. Svergun

8. Enantioselective Synthesis of Hydroxy Ketones via Benzoylformate Decarboxylase- and Benzaldehyde Lyase-Catalyzed C-C Bond Formation

113

(18)

Bettina Lingen, Martina Pohl, Ayhan S. Demir, Andreas Liese, and Michael Müller

9. Benzoylformate Decarboxylase: Lessons in Enzymology

131

(12)

Michael J. McLeish, George L. Kenyon, Elena S. Polovnikova, Asim K. Bera, Natalie L. Anderson, and Miriam S. Hasson

10. New Concept on the Nature of the Induced Absorption Band of Holotransketolase

143

(16)

Marina V. Kovira, Irina A. Sevostyanova, Olga N. Solovjeva, Ludmilla E. Meshalkina, and German A. Kochetov

11. Structure of the Œ-Carbanion/Enamine Reaction Intermediate in the Active Site of Transketolase, Determined by Kinetic Crystallography

159

(14)

Tatyana Sandalova, Erik Fiedler, Stina Thorell, Ralph Golbik, Stephan König, and Gunter Schneider

12. Yeast Pyruvate Decarboxylase: New Features of the Structure and Mechanism

173

(44)

Frank Jordan, Min Liu, Eduard Sergienko, Zhen Zhang, Andrew Brunskill, Palaniappa Arju~tan, and William Furey

13. Solvent and Carbon Kinetic Isotope Effects on Active-Site and Regulatory-Site Variants of Yeast Pyruvate Decarboxylase

217

(16)

Wen Wei, Min Liu, Lan Chen, W. Phillip Huskeg, and Frank Jordan

14. Insights into the Mechanism and Regulation of Bacterial Acetohydroxyacid Synthases

233

(18)

David M. Chipman, Ze'ev Barak, Stanislav Engel, Sharon Mendel, and Maria Vyazmensky

15. Structure and Properties of Acetohydroxyacid Synthase

251

(24)

Ronald G. Duggleby, Luke W. Guddas, and Siew Siew Pang

16. Exploring the Substrate Specificity of Benzoylformate Decarboxylase, Pyruvate Decarboxylase, and Benzaldehyde Lyase

275

(16)

Petra Siegert, Martina Pohl, Malea M. Kneen, Irina D. Pogozheva, George L. Kenyon, and Michael J. McLeish

17. Benzoylformate Decarboxylase: Intermediates, Transition States, and Diversions

291

(18)

Ronald Kluger, Qingyan Hu, and Ian F. Moore

Part IV: Structure and Function of Thiamine Diphosphate Multienzyme Complexes

18. Structural and Functional Organization of Pyruvate Dehydrogenase Complexes

309

(22)

Z. Hong Zhou, Lester Reed, and James K. Stoops

19. The Pyruvate Dehydrogenase Multienzyme Complex

331

(12)

Richard N. Perham, Jacqueline S. Milne, and Sriram Subramaniam

20. Activation and Transfer of Lipoic Acid in Protein Lipoylation in Mammals

343

(20)

Kazuko Fujiwara, Kazuko Okamura-Ikeda, and Yutaro Motokawa

21. Central Organization of Mammalian Pyruvate Dehydrogenase (PD) Complex and Lipoyl Domain-Mediated Activated Function and Control of PD Kinases and Phosphatase 1

363

(24)

Thomas E. Roche, Yasuaki Hiromasa, Ali Turkan, Xiaoming Gong, Tao Peng, Xiaohua Yan, Shane A. Kasten, Haiying Bao, and Jianchun Dong

22. Physiological Effects of Replacing the PDH Complex of E. coli by Genetically Engineered Variants or by Pyruvate Oxidase

387

(20)

John R. Guest, Ahmed M. Abdel-Hamid, Graham A. Auger, Louise Cunningham, Robin A. Henderson, Rosane S. Machado, and Margaret M. Attwood

23. Structure and Intersubunit Information Transfer in the E. coli Pyruvate Dehydrogenase Multienzyme Complex

407

(26)

William Furey, Palaniappa Arjunan, Andrew Brunskill, K. Chandrasekhar, Natalia S. Nemeria, Wen Wei, Yan Yan, Sheng Zhang, and Frank Jordan

24. Structure, Function, and Regulation of Pyruvate Dehydrogenase Kinase

433

(16)

Kirill M. Popov, Alma Tuganova, Mellissa M. BowkerKinley, Boli Hung, Pengfei Wu, C. Nicklaus Steussy, Jean Hamilton, and Robert A. Harris

25. Three-Dimensional Structures for Components and Domain of the Mammalian Branched-Chain a-Ketoacid Dehydrogenase Complex

449

(22)

David T. Chuang, R. Max Wynn, and Jacinta L. Chuang

Part V: Biomedical Aspects of Thiamine Diphosphate Dependent Enzymes

26. Variability of Human Pyruvate Dehydrogenase Complex Deficiency

471

(14)

Douglas S. Kerr and Christine L. Schmotzer

27. Kinetic Studies of Human Pyruvate Dehydrogenase and Its Mutants: Interactions with Thiamine Pyrophosphate

485

(24)

Mulchand S. Patel and Lioubov G. Korotchkina

28. The Complexity of Single-Gene Disorders: Lessons from Maple Syrup Urine Disease and Thiamine Responsiveness

509

(16)

Dean J. Danner, Eric A. Muller, and Andrea Kasinski

29. Thiamine Pyrophosphate: An Essential Cofactor in the Mammalian Metabolism of 3-Methyl-Branched Fatty Acids

525

(14)

Minne Casteels, Veerle Foulon, Guy P. Mannaerts, and Paul P. Van Veldhoven

30. Pathogenesis of Selective Neuronal Loss in Wernicke Korsakoff Syndrome: Role of Oxidative Stress

539

(10)

Paul Desjardins and Roger F. Butterworth

31. Thiamine-Responsive Megaloblastic Anemia Syndrome: Clinical Aspects and Molecular Genetics

549

(16)

Kimihiko Oishi, George A. Diaz, and Bruce D. Gelb

Part VI: Concluding Remarks

32. Accomplishments and Future Directions

565

(4)

Frank Jordan and Mulcharad S. Patel

Index

569

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Thiamine: Catalytic Mechanisms in Normal and Disease States

Summary

Table of Contents

Supplemental Materials

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Thiamine: Catalytic Mechanisms in Normal and Disease States

Summary

Table of Contents

Supplemental Materials

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