Thrombus And Stroke

Providing a clear foundation as to what a clot is, how it forms, and the most recent approaches to treatment this all inclusive resource on thrombus and stroke covers:Â· current pharmacological interventionsÂ· clinical management of stroke.Â· the fundamental science of clot formation and the pharmacokinetics of thrombolysisÂ· latest findings on neurovascular diseaseÂ· thrombogenicity of vascular implants and the methods to assess the efficacy of anticoagulation therapyÂ· clinical impact of thrombus as it pertains to stroke and the most recent clinical and minimally'invasive approaches to this disorderFrom the latest imaging techniques, to endovascular treatments and more, this new comprehensive and up-to-date volume provides critical information needed for diagnosis and treatment. It includes valuable information to assist physicians in the prevention of future strokes and long-term complications and toimprove patient outcomes throughout the rehabilitation process.

Preface	p. iii
Contributors	p. ix
Basic Science	p. 1
Thrombus Formation	p. 3
Introduction	p. 3
Platelets	p. 3
The Coagulation Cascade	p. 5
References	p. 12
Blood Flow and Thrombus Formation	p. 15
Blood Rheology	p. 15
Hemodynamics and their Interaction with Blood and the Vessel Wall	p. 16
Clinical Problems Associated with Arterial Stenosis	p. 17
Platelets' Hemostatic Response	p. 19
Flow-Induced Platelet Activation-"Dose" and Time Revisited	p. 19
Fluid Mechanical Factors Implicated in Platelet Activation and Aggregation	p. 20
Experimental and Numerical Flow Studies	p. 21
Flow and Thrombolysis	p. 21
Thromboembolism in Blood Recirculating Devices	p. 23
Device Thromboembolism and its Consistency	p. 24
The Significance of Studying Platelet Activation over Hemolysis in Devices	p. 26
Measuring the Thrombogenic Potential of Devices	p. 27
Stent/Coil Thrombosis	p. 28
Summary	p. 30
References	p. 30
In Vivo Experimental Models of Focal Ischemic Stroke	p. 39
Introduction	p. 39
Animal Models of Focal Ischemic Stroke	p. 40
Conclusion	p. 50
References	p. 51
Assessment and Management of Vascular Implant Thrombogenecity	p. 57
Introduction	p. 57
In Vitro Models	p. 57
Ex Vivo Shunt Model	p. 66
In Vitro Diagnostic Tests	p. 68
Summary	p. 73
References	p. 74
Clinical Implications	p. 79
Stroke Imaging (CT, MR, SPECT, PET)	p. 81
Introduction	p. 81
Unenhanced Cranial Computed Tomography	p. 81
CT Angiography	p. 84
CT Perfusion	p. 87
Magnetic Resonance Imaging	p. 89
Diffusion-weighted MR-Imaging	p. 90
Perfusion-weighted MR-Imaging	p. 92
MR Angiography	p. 94
MR Spectroscopy	p. 96
Single-Photon Emission Computed Tomography	p. 96
Positron Emission Tomography	p. 97
Future Directions	p. 97
Conclusion	p. 98
References	p. 98
Pharmacology and Clot: Immediate and Chronic Interventions	p. 103
Introduction	p. 103
"Brain Attack" Versus "Heart Attack"	p. 103
Thrombolytic Agents	p. 105
Antiplatelet Agents	p. 107
Anticoagulants	p. 113
Stents and Antiplatelet Therapy	p. 117
Limitations of Antiplatelet Medications	p. 117
References	p. 119
Acute Ischemic Stroke: Endovascular Revascularization and Reperfusion	p. 123
Introduction	p. 123
Mechanical Revascularization	p. 124
Miscellaneous	p. 150
Conclusion	p. 153
References	p. 154
The Future of Neuroprotection	p. 159
Rationale for Neuroprotective Strategies	p. 159
The History of Neuroprotection: A Lack of Positive Results	p. 160
Formation of STAIR Criteria	p. 161
The Hope Provided by the SAINT-I Trial and the Disappointment of SAINT-II	p. 162
The Future of Neuroprotection: New Recommendations for Clinical Trial Design	p. 163
Conclusion	p. 164
References	p. 164
Acute Ischemic Stroke: Paradigm for Treatment	p. 167
Introduction	p. 167
Imaging	p. 168
Treatment	p. 177
Conclusion	p. 198
References	p. 198
Index	p. 203
Table of Contents provided by Ingram. All Rights Reserved.

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