Tissue Stem Cells

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ISBN: 9780824728991 | 0824728998
Cover: Hardcover
Copyright: 4/24/2006

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Tissue stem cells and their medical applications have become a major focus of research over the past decade. With 16 full-color illustrations, this reference provides a thorough and up-to-date overview of the current and emerging technologies for stem cell research and transplantation. Divided into three sections covering general issues, adult stem cells within specific tissues, and clinical applications, this source studies advances in bone marrow transplantation, cancer development modeling, tumor analysis, and gene therapy.

Preface

Contributors

Mathematical Modeling of Stem Cells: A Complexity Primer for the Stem-Cell Biologist

(16)

Mark d'Inverno

Neil Theise

Jane Prophet

Introduction

(4)

Emergence

(2)

Complex Adaptive Systems with Multiple Interacting Agents

(1)

Modeling Stem Cells and Cell Lineages as Complex Adaptive Systems

(5)

Ramifications for Current Thinking

(1)

Conclusion

(1)

References

(3)

Theoretical Concepts of Tissue Stem-Cell Organization

(20)

Ingo Roeder

Joerg Galle

Markus Loeffler

Introduction

(1)

Defining Tissue Stem Cells

(1)

Conceptual Challenges in Tissue Stem-Cell Biology

(1)

Predictive Theories and Quantitative Models

(1)

A New Perspective on Stem-Cell Systems

(2)

Modeling of the Dynamics of Clonal Competition in Hematopoietic Stem Cells

(4)

Spatio-Temporal Stem-Cell Organization

(3)

Conceptual Novelty and Achievements

(3)

References

(5)

Mechanisms of Genetic Fidelity in Mammalian Adult Stem Cells

(18)

James L. Sherley

Evolution of Mechanisms of Mammalian Tissue Cell Genetic Fidelity: The Needs of a Few

(2)

An Exact Definition for the Long-Lived Nature of ASCs

(1)

Mutagenesis Mechanisms in ASCs

(1)

Immortal DNA Strand Co-Segregation and a Carpenter's Rule for Genetic Fidelity in ASCs

(2)

Implications of the Carpenter's Rule for ASC Aging, Cell Kinetics, and DNA Repair Functions

(2)

Estimation of the Mutation-Avoidance Effect of an Immortal DNA Strand Mechanism in ASCs

(2)

Evidence for Immortal DNA Strand Co-Segregation in ASCs

(5)

References

(3)

Neural Stem Cells: Isolation and Self-Renewal

(16)

Hideyuki Okano

Jun Kohyama

Hiroyuki Ohba

Masanori Sakaguchi

Akinori Tokunaga

Takuya Shimazaki

Hirotaka James Okano

Introduction

(1)

In Vivo Localization of NSCs

(5)

Control of the Self-Renewal and Differentiation of NSCs

(6)

Conclusion and Perspectives

(1)

References

(5)

Stem Cells in Mammary Epithelium

(18)

Gilbert H. Smith

Robert B. Clarke

Introduction

(1)

Aging and Reproductive Senescence

(1)

In Vitro Studies

(4)

Mammary Stem-Cell Markers

(6)

Mammary Stem Cells in Carcinogenesis

(2)

Pregnancy and Breast Cancer Risk

(1)

Future Prospects

(1)

References

(4)

Lineage Tracking, Regulation, and Behaviors of Intestinal Stem Cells

(28)

Melissa H. Wong

Adnan Z. Rizvi

Introduction

(1)

Intestinal Epithelium

(7)

Lineage Tracking as an Approach to Understanding the Stem-Cell Behavior

(5)

Tracking Stem-Cell Fate Through Understanding What Regulates Their Proliferation and Differentiation

101

(8)

Identifying Markers for Intestinal Stem Cells

109

(2)

Conclusion

111

(1)

References

111

(6)

Stem Cell Populations in Skin

117

(32)

Richard P. Redvers

Pritinder Kaur

Introduction

117

(18)

Conclusion

135

(1)

References

135

(14)

A Perspective on In Vitro Clonogenic Keratinocytes: A Window into the Regulation of the Progenitor Cell Compartment of the Cutaneous Epithelium

149

(12)

Rebecca J. Morris

Introduction

149

(1)

Cutaneous Epithelium as a Continually Renewing Tissue Containing In Vitro Clonogenic Keratinocytes

149

(1)

Functional Evidence of Stem Cells in Epidermis and Hair Follicles

150

(7)

In Mice, Keratinocyte Colony Number is Genetically Defined and Quantitatively Complex

157

(1)

Keratinocyte Colony Size is Also Genetically Defined

158

(1)

Summary

159

(1)

References

159

(2)

Hepatic Stem Cells and the Liver's Maturational Lineages: Implications for Liver Biology, Gene Expression, and Cell Therapies

161

(54)

Eva Schmelzer

Randall E. McClelland

Aloa Melhem

Lili Zhang

Hsin-lei Yao

Eliane Wauthier

William S. Turner

Mark E. Furth

David Gerber

Sanjeev Gupta

Lola M. Reid

The Liver as a Maturational Lineage System

161

(7)

General Comments on Stem Cells

168

(1)

Hepatic Stem Cells

169

(14)

Gene Expression

183

(5)

Reconstitution of Liver by Cell Transplantation

188

(5)

Liver Cell Therapies---Clinical Programs

193

(5)

Conclusion

198

(1)

References

199

(16)

Multistage Carcinogenesis: From Intestinal Stem Cell to Colon Cancer in the Population

215

(14)

E. Georg Luebeck

Introduction

215

(2)

A Biologically Based Multistage Model for Colon Cancer

217

(4)

Adenomatous Polyps---Observations and Model Predictions

221

(4)

Summary

225

(1)

References

226

(3)

Intestinal Stem Cells and the Development of Colorectal Neoplasia

229

(42)

Stuart A. C. McDonald

Trevor Graham

Christopher S. Potten

Nicholas A. Wright

Ian P. M. Tomlinson

Andrew G. Renehan

Introduction

229

(1)

Basic Structure and Function of the Intestinal Crypt

230

(4)

Stem-Cell Hierarchy

234

(2)

Crypt Clonality

236

(2)

Intestinal Stem-Cell Repertoire

238

(1)

The Concept of Stemness and ``Immortal'' DNA Strands

239

(3)

Molecular Regulation of Normal Intestinal Crypt Homeostasis

242

(8)

Early Molecular Events in Colorectal Tumorigenesis

250

(2)

Intestinal Stem Cells and the Origin of Colorectal Cancer

252

(1)

Colorectal Tumor Morphogenesis

253

(3)

Clinical Implications and Future Directions

256

(2)

Summary

258

(1)

References

259

(12)

Stem Cells in Neurodegeneration and Injury

271

(34)

Reaz Vawda

Nigel L. Kennea

Huseyin Mehmet

Introduction

271

(1)

Stem Cells

272

(13)

The Use of Stem Cells in Brain Disease and Injury

285

(8)

Future Perspectives

293

(1)

References

293

(12)

Adult Stem Cells and Gene Therapy

305

(34)

Ilaria Bellantuono

Leslie J. Fairbairn

Introduction

305

(1)

Adult Stem Cells for Gene Therapy

306

(4)

Gene Delivery

310

(5)

Hurdles to Stem-Cell Gene Therapy

315

(6)

Conclusion

321

(1)

References

322

(17)

Clinical Applications of Hematopoietic Stem Cells

339

(50)

Joanne Ewing

Yvonne Summers

Introduction

339

(1)

Clinical Use of HSCs in Transplantation

339

(2)

Autologous Stem-Cell Transplantation

341

(2)

ASCT: Malignant Diseases

343

(8)

ASCT: Nonmalignant Diseases

351

(2)

Allogeneic Stem-Cell Transplantation

353

(4)

Specific Clinical Indications for Allogeneic Transplant

357

(6)

Cord Blood Transplantation

363

(9)

Conclusion

372

(1)

References

373

(16)

Index

389

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Tissue Stem Cells

Summary

Table of Contents

Supplemental Materials