Tissue-Specific Vascular Endothelial Signals

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Contributors	p. vii
Inhibition of Vascular Endothelial Growth Factor Receptor Signaling in Angiogenic Tumor Vasculature	p. 1
Introduction	p. 2
VEGF/VEGFR Signaling Pathway as a Target of Antiangiogenic Therapy	p. 3
Strategies to Inhibit the VEGF/VEGFR Signaling	p. 4
Using VEGFR-2 for Targeted Delivery of Powerful Toxic Agents	p. 8
Summary	p. 22
References	p. 22
Adeno-Associated Viral Vectors and Their Redirection to Cell-Type Specific Receptors	p. 29
Introduction	p. 30
Capsid Modifications of AAV to Target Cellular Receptors	p. 38
Selecting Novel AAV Vectors from Combinatorial Libraries	p. 41
Perspectives	p. 50
References	p. 51
Tissue-Specific Targeting Based on Markers Expressed Outside Endothelial Cells	p. 61
Introduction	p. 62
Nonendothelial Tissue-Specific Targets of Systemically Administered Agents	p. 69
Concluding Remarks and Future Directions	p. 90
Acknowledgment	p. 92
References	p. 92
Ligand-directed Cancer Gene Therapy to Angiogenic Vasculature	p. 103
Introduction	p. 104
Therapeutic Concepts in Cancer Gene Therapy	p. 105
Vectors for Ligand-directed Gene Delivery	p. 109
Ligands for Targeting Angiogenic Vasculature	p. 112
Conclusion	p. 115
References	p. 115
Index	p. 123
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Tissue-Specific Vascular Endothelial Signals and Vector Targeting, Part A

Summary

Table of Contents

Supplemental Materials