Tissue-Specific Vascular Endothelial Signals and Vector Targeting, Part B

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ISBN: 9780123750228 | 0123750229
Cover: Hardcover
Copyright: 9/13/2010

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The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics research. This serial continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.* Includes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, providing researchers an overview and synthesis of the latest findings in the area * Presents up-to-date research from leaders in the field

Contributors	p. ix
MR Molecular Imaging of Tumor Vasculature and Vascular Targets	p. 1
Introduction	p. 2
Structural, Functional, and Molecular Characteristics of Tumor Vasculature	p. 3
Basis of Contrast in MR Images	p. 7
Imaging Receptor Expression	p. 16
Imaging Vascular Targeting	p. 17
Multimodal Molecular-Functional Imaging of Tumor Vasculature	p. 19
Conclusion	p. 21
References	p. 22
An Integrated Approach for the Rational Design of Nanovectors for Biomedical Imaging and Therapy	p. 31
Introduction	p. 32
Three Generations of Nanovectors	p. 34
Mathematical Models for Predicting the Nanovectors' Behavior	p. 39
Biophysical Characterization of Nanovectors	p. 48
Vascular Targeting Moieties	p. 50
In vitro Assays for Nanovectors' Characterization	p. 53
Intravital Video Microscopy	p. 55
Conclusions	p. 57
References	p. 59
Targeted Systemic Gene Therapy and Molecular Imaging of Cancer: Contribution of the Vascular-Targeted AAVP Vector	p. 65
Introduction	p. 66
Targeted Gene Delivery	p. 68
Conclusions and Perspectives	p. 79
References	p. 80
Cationic and Tissue-Specific Protein Transduction Domains: Identification, Characterization, and Therapeutic Application	p. 83
Introduction	p. 84
Cationic Protein Transduction Domains	p. 84
Biopanning using Peptide Phage Display Libraries	p. 85
Peptide Phage Display Biopanning in Cell Culture for Transduction Peptides	p. 87
Methods for Analysis of Transduction Efficiency	p. 90
Peptide Phage Display Biopanning in vivo for Transduction Peptides	p. 91
PTDs as Therapeutics	p. 92
Conclusions	p. 93
References	p. 93
GRP78 Signaling Hub: A Receptor for Targeted Tumor Therapy	p. 97
Introduction	p. 99
GRP78 Association with Activated ¿2-Macroglobulin Promotes Cell Proliferation	p. 101
GRP78 Autoantibody Predicts Poor Prognosis in Tumors but Shows Therapeutic Effects in Rheumatoid Arthritis	p. 102
GRP78 Promotes Endothelial Cell Survival in Association with T-Cadherin	p. 103
Cripto Mitogenic Signaling is GRP78-Dependent	p. 103
Interaction of GRP78 with Plasminogen Kringle 5 and Microplasminogen Leads to Apoptosis or the UPR	p. 104
GRP78 Association with Extracellular Par-4 Activates the Extrinsic Apoptotic Pathway	p. 105
GRP78 Inhibits Tissue Factor-Mediated Procoagulant Activity	p. 107
GRP78 Targeting Peptides Inhibit Tumor Growth	p. 108
Conclusions	p. 109
References	p. 110
On the Synergistic Effects of Ligand-Mediated and Phage-Intrinsic Properties During in Vivo Selection	p. 115
Introduction	p. 116
Ligand-Receptor Mediated Effects	p. 118
Synergistic Effects Intrinsic to Phage	p. 124
Conclusion	p. 130
References	p. 130
Strategies for Targeting Tumors and Tumor Vasculature for Cancer Therapy	p. 135
Introduction	p. 136
Isolated Limb Perfusion	p. 136
Isolated Liver Perfusion	p. 137
Chemoembolization	p. 138
Gene Therapy Strategies Available to Target the Tumor and the Tumor-Associated Vasculature	p. 139
Conclusions	p. 148
References	p. 148
Index	p. 153
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