Topical Antimicrobial Testing and Evaluation

Presents & reviews techniques for testing antibacterial compounds-providing industry & academia with the ways of getting products approved by the FDA & the means of servicing expanding markets. Discusses & illustrates the most effective methods for testing efficacy & safety of preinjection & preoperative washes, healthcare & food service workers' handwashes, & surgical scrubs.

Foreword

iii

Ken Wilber

Preface

v

General Approach to Developing Topical Antimicrobials

1

(16)

The Holonic Quadrant Model

1

(3)

A Chronic Problem: Reductionism

4

(11)

Conclusion

15

(2)

Skin Properties

17

(8)

Structure

17

(1)

The Epidermis

18

(3)

The Dermis

21

(1)

Dermal Vascularization

22

(2)

The Tissue Fluids

24

(1)

Skin Microbiology

25

(28)

Etiology of Infectious Diseases

25

(4)

The Bacterial Cell

29

(17)

Mycology (Fungi)

46

(4)

Viruses

50

(3)

Current Topical Antimicrobials

53

(8)

Iodine Complexes

53

(3)

Chlorhexidine Gluconate

56

(2)

Parachlorometaxylenol (PCMX)

58

(1)

Alcohols

59

(1)

Triclosan

59

(2)

Measurement of Antimicrobial Action of Topical Antimicrobials

61

(16)

General Performance Characteristics

61

(5)

The Research Situation

66

(3)

Microbiological Methodology

69

(1)

Statistical Methods Used to Evaluate the Study

70

(1)

New Product Development Applications

71

(5)

Conclusion

76

(1)

Epistemological Requirements in Evaluating the Effects of Specific Treatments

77

(14)

Experimental Strategy

77

(1)

Choosing Qualitative or Quantitative Methods

77

(1)

Statistical Methods

78

(2)

Statistical Model-Building and Analysis

80

(3)

Parametric Statistics

83

(1)

Nonparametric Statistics

84

(1)

Qualitative Research Designs

85

(1)

Phenomenological Designs

86

(1)

Heuristic Designs

87

(1)

Historical Research Design

88

(1)

Evaluative Research Design

88

(1)

Conclusion

89

(2)

Evaluation Strategies and Sample Working Protocols

91

(50)

Consumer Antimicrobial Products

91

(3)

Healthcare Personal Handwash Evaluations

94

(2)

Proposed Antimicrobial Handsoap Evaluation

96

(6)

Sample Protocols (to be modified as required)

102

(6)

General-Use Handwash Evaluation

108

(1)

Evaluating Antimicrobial Body Soaps/Lotions

108

(4)

Foodhandler Antimicrobial Handwash Evaluation

112

(5)

Medical/Healthcare Industry Antimicrobials

117

(24)

Overview of Statistical Methods

141

(58)

The Purpose of the Evaluation

141

(6)

Introduction to Statistical Inference

147

(21)

Analysis of Variance (ANOVA)

168

(20)

Kruskal-Wallis Statistic

188

(11)

References

199

(6)

Index

205

What is included with this book?

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Topical Antimicrobial Testing and Evaluation

Summary

Table of Contents

Supplemental Materials

FREE SHIPPING

Rent More, Save More! Use code: BBRENTAL

5% off 1 book, 7% off 2 books, 10% off 3+ books

Topical Antimicrobial Testing and Evaluation

Summary

Table of Contents

Supplemental Materials

Digital License