Trace Quantitative Analysis by Mass

This book provides a serious introduction to the subject of mass spectrometry, providing the reader with the tools and information to be well prepared to perform such demanding work in a real-life laboratory. This essential tool bridges several subjects and many disciplines including pharmaceutical, environmental and biomedical analysis that are utilizing mass spectrometry:Covers all aspects of the use of mass spectrometry for quantitation purposes Written in textbook style to facilitate understanding of this topic Presents fundamentals and real-world examples in a 'learning-though-doing' style

Professor Robert K Boyd, National Research Council, Institute for National Measurement Standards, Ottawa, Canada
Robert Boyd obtained his B Sc and Ph D from St Andrews University. In 1962 he took a post-doctoral fellow position at NRC followed by periods at the University of Toronto & University of Guelph. In 1986 he re-joined the NRC, and since that time has served as adjunct professor at Dalhousie University (1992-2001). Since 2001 he has been Researcher Emeritus at the NRC in Ottawa.
Professor Boyd has published over 160 research papers, four book chapters & 10 NRC Technical reports. In 1002 he received the Maxxam Award for Analytical Chemistry and in 2003 the Queen Elizabeth II Gold Jubilee Medal. He is currently Chair of the Science Advisory Board for the Genome Prarie project on enabling technologies for proteomics. And a member of the NSERC Committee for Scientific & Technical review of ISTC proposals. He was an editor for Rapid Communications in Mass Spectrometry from 1990 – 1997 and from 1997 – 2005 was the journal's Editor-in-Chief.

Dr Robert A Bethem, senior VP of the Bioanalytical Group at Alta Analytical Laboratory, CA, USA and Professor Dwight Matthews of the University of Vermont, USA

Preface
Acknowledgements
Measurement, Dimensions and Units
Introduction
The International System of Units (SI)
'Mass-to-Charge Ratio' in Mass Spectrometry
Achievable Precision in Measurement of SI Base Quantities
Molecular Mass Limit for Trace Quantitation by Mass Spectrometry
Summary of Key Concepts
Tools of the Trade
The Classical Tools
Introduction
Analytical and Internal Standards: Reference Materials
The Analytical Balance
Measurement and Dispensing of Volume
Preparation of Solutions for Calibration
Introduction to Calibration Methods for Quantitative Analysis
Summary of Key Concepts
Tools of the Trade
Theory of Chromatography
Introduction
General Principles of Chemical Separations
Summary of Important Concepts
Plate Theory of Chromatography
Nonequilibrium Effects in Chromatography: the van Deemter Equation
Gradient Elution
Capillary Electrophoresis and Capillary Electrochromatography
Derivation of the Plate Theory Equation for Chromatographic Elution
Transformation of the Plate Theory Elution Equation from Poisson to Gaussian Form
A Brief Introduction to Snyder's Theory of Gradient Elution List of Symbols Used in Chapter
Tools of the Trade
Separation Practicalities
Introduction
The Analyte and the Matrix
Extraction and Clean-Up: Sample Preparation Methods
Chromatographic Practicalities
Summary of Key Concepts
Responses of Chromatographic Detectors: Concentration vs Mass-Flux Dependence
Tools of the Trade
Interfaces and Ion Sources for Chromatography-Mass Spectrometry
Introduction
Ion Sources that can Require a Discrete Interface Between Chromatograph and Source
Ion Sources not Requiring a Discrete Interface
Source-Analyzer Interfaces Based on Ion Mobility
Summary of Key Concepts
Appendix
Methods of Sample Preparation for Analysis by MALDI
Tools of the Trade
Mass Analyzers for Quantitation: Separation of Ions by m/z Values
Introduction
Mass Analyzer Operation Modes and Tandem Mass Spectrometry
Motion of Ions in Electric and Magnetic Fields
Mass Analyzers
Activation and Dissociation of Ions
Vacuum Systems
Summary of Key Concepts
Interaction of Electric and Magnetic Fields with Charged Particles
Leak Detection
List of Symbols Used in Chapter
Tools of the Trade
Ion Detection and Data Processing
Introduction
Faraday Cup Detectors
Electron Multipliers
Post-Detector Electronics
Summary of Key Concepts
Tools of the Trade
Statistics of Calibration, Measurement and Sampling
Introduction
Univariate Data: Tools and Tests for Determining Accuracy and Precision
Bivariate Data: Tools and Tests for Regression and Correlation
Limits of Detection and Quantitation
Calibration and Measurement: Systematic and Random Errors
Statistics of Sampling of Heterogeneous Matrices
Summary of Key Concepts
A Brief Statistics Glossary
Symbols Used in Discussion of Calibration Methods
Method Development and Fitness for Purpose
Introduction
Fitness for Purpose and Managing Uncertainty
Issues Between Analyst and Client: Examining What#8
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Trace Quantitative Analysis by Mass Spectrometry

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