Translational Nanomedicine

Preface vii

Part I Laboratory Techniques 1

1 Microfluidics in Nanomedicine 3
YongTae Kim and Robert Langer

2 Quantum Dots for Biomedical Delivery Applications 29
Abolfazl Akbarzadeh, Sedigheh Fekri Aval, Roghayeh Sheervalilou, Leila Fekri, Nosratollah Zarghami, and Mozhdeh Mohammadian

Part II Devices 43

3 DNA Origami Nanorobots 45
Ido Bachelet

4 Graphene and Graphene Derivatives in Biosensing, Imaging, Therapeutics, and Genetic Engineering 71
KimTruc Nguyen and Yanli Zhao

5 Synthetic Gene Circuits 107
Barbara Jusiak, Ramiz Daniel, Fahim Farzadfard, Lior Nissim, Oliver Purcell, Jacob Rubens, and Timothy K. Lu

6 Synthetic Hybrid Biosensors 163
Apoorv Shanker, Kangwon Lee, and Jinsang Kim

Part III Pharmaceutical Delivery 199

7 Carbon Nanotubes for Enhanced Biopharmaceutical Delivery 201
Harikrishna Rallapalli and Bryan Ronain Smith

8 Cholesterol in Nanobiotechnology 227
Philipp Schattling, Yan Zhang, Boon M. Teo, and Brigitte Städler

9 Nanoparticle Conjugates for Small Interfering RNA Delivery 279
Timothy L. Sita and Alexander H. Stegh

10 Role of Scavenger Receptors in Immune Recognition and Targeting of Nanoparticles 305
Guankui Wang and Dmitri Simberg

Part IV Cancer 329

11 Gold and Iron Oxide Nanoparticles with Antibody Guides to Find and Destroy Cancer Cells 331
Stephanie A. Parker, Isabel A. Soto, Dickson K. Kirui, Cameron L. Bardliving, and Carl A. Batt

12 RNA Interference in Cancer Therapy 357
Barbara Pasculli and George A. Calin

13 Smart Nanoparticles in Brain Cancer Therapy 411
Yinhao Wu, Tao Sun, Lisha Liu, Xi He, Yifei Lu, Sai An, and Chen Jiang

Part V Tissue Engineering and Regeneration 429

14 Bone Tissue Engineering: Nanomedicine Approaches 431
Michael E. Frohbergh, Peter Newman, Calogera M. Simonaro, and Hala Zreiqat

Index 457

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