One of the Most Rapidly Advancing Fields in Modern Neuroscience
Series Preface
p. xv
Preface
p. xvii
The Editors
p. xxi
Contributors
p. xxiii
Painful Multi-Symptom Disorders: A Systems Perspective
p. 1
Neurotrophic Factors and Nociceptor Sensitization
p. 31
The Role of Visceral Afferents in Disease
p. 51
Cancer Pain: From the Development of Mouse Models to Human Clinical Trials
p. 77
Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States
p. 99
Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes
p. 139
Transgenic Mouse Models for the Tracing of "Pain" Pathways
p. 163
Cytokines in Pain
p. 187
Glial Modulation in Pain States: Translation into Humans
p. 215
On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory, and Neuropathic Pain
p. 235
Myalgia and Fatigue: Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes
p. 251
Reflex Autonomic Responses Evoked by Group III and IV Muscle Afferents
p. 283
Central Pain as a Thalamocortical Dysrhythmia: A Thalamic Efference Disconnection?
p. 301
What Can Neuroimaging Tell Us about Central Pain?
p. 315
Human Brain Imaging Studies of Chronic Pain: Translational Opportunities
p. 329
Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs
p. 349
Large Animal Models for Pain Therapeutic Development
p. 371
Drug Discovery and Development for Pain
p. 391
Index
p. 405
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