Translational Research and Discovery in Gastroenterology Organogenesis to Disease

Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs.

The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners.

Notable features include the following:

• Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic.

• Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs.

• Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included.

• Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.

Deborah L. Gumucio, PhD, is the James Douglas Engel Professor and Interim Chair of the Department of Cell and Developmental Biology at the University of Michigan Medical School and Project Director of the University of Michigan’s BioArtography Program.

Linda C. Samuelson, PhD, is the John A. Williams Collegiate Professor of Gastrointestinal Physiology and Professor in the Departments of Molecular and Integrative Physiology and Internal Medicine at the University of Michigan Medical School and serves as Associate Director for the Center for Organogenesis at the University of Michigan.

Jason R. Spence, PhD, is Assistant Professor of Internal Medicine and Assistant Professor of Cell and Developmental Biology at the University of Michigan Medical School.

Introduction – 1 chapter
Embryology overview, from gastrulation to endodermal tube and accessory organ formation, including timing of events in human vs mouse
Patrick Tam, Brigid Hogan, Jim Wells

Esophagus -2 chapters
Development: Jianwen Que - development/including esophageal tracheal development, studies related to Barrett’s
Clinical: –John Lynch – Barretts esophagus, tracheal esophageal fistula

Stomach -2 chapters
Development: Tae-Hee Kim (Shivdasani lab): stomach development/including mouse models of gastroschesis, volvulus
Clinical: Ramesh Shivdasani or Jason Mills

Pylorus -1 chapter (combined development and clinical)
Development: Deb Gumucio
Clinical: Brent Polk
Development of the pylorus/Idiopathic Hypertrophic pyloric stenosis

Small intestine -2 chapters
Development: Klaus Kaestner or Nan Guo or Noah Shroyer: development, major transcriptional networks, generation of villi/absorptive surface, generation of intestinal length.
Clinical: Dan Teitlebaum or Mike Helmrath Short bowel, intestinal atresias

Colon 2 - chapters
Development: Thad Stappenbeck or Martin J. Cohn or David Ornitz
Hindgut development, anorectal malformations , caudal regression.
Clinical: Yukio Saijoh (U of Utah) or Thad Stappenbeck

Liver -2  chapters
Development: Ben Stanger or Aaron Zorn or Ken Zaret or Steve Duncan or Fredrick P Lemaigre – include pancreas/liver/biliary choice, cholangiocyte-hepatocyte switch, chromatin considerations (pioneer factors?)
Clinical- Ben Stanger or Ira J. Fox or Steve Duncan

Pancreas -2 chapters
Development: Doug Melton, Jim Wells, Mattias Hebrok, Charles Murtaugh, Chris Wright, Guoqiang Gu, Ray McDonald
Clinical: Martin Martin, Roland Stein, Steve Leach, Rolan Schmid include type 1 diabetes, rare conditions where isets don't develop, ngn3 mutant people, acinar diseases

Serosa-1 chapter
David Bader – include developmental potential of the serosa; apple peel bowel

Enteric nervous system - 2 chapters
Michelle Southhard Smith – development of the enteric nervous system
Michael Gershon, MD – Hirshprung’s, other diseases of ENS

Gut Stem Cells – 1 chapter
Linda Samuelson – include major intestinal and stomach stem cells, contrast with liver and pancreas

Other model organisms for the study of various aspects of gut development – up to 5 chapters
Fly- Ben Ohlstein or Tony Ip
Zebrafish - Didier Stainer (liver, pancreas, gut lumen), or Vicky Prince…endoderm patterning, pancreas), or Michael Pack (liver)
Frog- Aaron Zorn, Chris Wylie, or Janet Heaseman
Worm - Susan Mango or James McGee
Sea Urchin - Dave McClay

The Future – translational gut embryology - 1 chapter
Jason Spence – human pluripotent stem cells to generate 2D/3D in vitro models to study human development and disease.

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.