Trends in Receptor Research: Proceedings of

The 8th Camerino-Noordwijkerhout Symposium has continued along its traditional path of interdisciplinary cooperation. Chemists, biochemists, pharmacologists, biophysicists and physiologists are all involved in the task of improving our knowledge of the mechanisms of drug-receptor interaction and of the heterogeneous nature of biological molecules. In this volume, leading researchers have contributed state of the art information on receptor chemistry. Newest developments are covered with particular reference to receptors of the nervous system; SAR studies; receptor isolation; receptor cloning; receptor topography; biomedical consequences of occupancy; receptor regulation and receptor theory. This will be of great interest to pharmacologists, biochemists and medicinal chemists, as well as a valuable source of reference for medical students and postgraduate students in related fields.

Preface
Bernard Belleau: Medicinal Chemist. 1925-1989	p. 1
Design, anti-HIV activity, cellular pharmacology and conformation of BCH-189 [actual symbol not reproducible], a novel nucleoside analogue	p. 7
Theoretical and practical advantages and limitations of techniques used in functional pharmacological classification of drug receptors	p. 31
Is pharmacological analysis of agonist action useful in medicinal chemistry?	p. 43
The hydrogen bonding of drugs: its experimental determination and role in pharmacokinetics and pharmacodynamics	p. 61
Presynaptic receptors modulating transmitter release: physiological and pharmacological aspects	p. 73
Presynaptic auto- and hetero-receptors in the cholinergic regulation of pain	p. 95
Heterogeneity of [alpha][subscript 2]-adrenoceptors: clinical aspects	p. 115
Histamine H[subscript 3] receptors: novel ligands and responses	p. 141
Selective alpha adrenergic agents - Differentiation of receptor subtypes	p. 153
Stereoisomeric, photoaffinity, affinity and fluorescent probes for characterization of dopamine D[subscript 1] and D[subscript 2] receptors	p. 175
Serotonin receptors, 5-HT ligands and receptor modeling	p. 185
Excitatory amino acid receptors: multiplicity and ligand specificity of the NMDA and AMPA receptor subtypes	p. 209
Tricyclic compounds as selective muscarinic antagonists: structure activity relationships and therapeutic implications	p. 231
Design of high efficacy agonists at cortical muscarinic receptors	p. 251
Multidisciplinary analysis of muscarinic receptors in guinea-pig isolated ileum, atria and uterus in vitro	p. 273
Molecular biology of the GABA[subscript A] receptor	p. 295
Potassium channel openers: pharmacology and therapeutic prospects	p. 309
L-type calcium channels and calcium channel ligands	p. 333
Central cholecystokinin receptors: opportunity for drug discovery	p. 345
Drug modeling at cell membrane receptors: the concept of pseudoreceptors	p. 367
Concluding comments	p. 405
Messengers and modulators - Receptors and enzymes	p. 409
Author index	p. 419
Subject index	p. 421
Table of Contents provided by Blackwell. All Rights Reserved.

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Trends in Receptor Research: Proceedings of the 8th Camerino-Noordwijkerhout Symposium, Camerino, Italy, 8-12 September 1991

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